Naples Prognostic Score as an Independent Predictor of Survival Outcomes for Resected Locally Advanced Non-Small Cell Lung Cancer Patients After Neoadjuvant Treatment

Zou, Zhi; Li, Jinping; Ji, Xiang; Wang, Tingxing; Chen, Qingqing; Liu, Zhengcao; Ji, Shengjun

doi:10.2147/jir.s401446

Cited by 4 publications

(2 citation statements)

References 60 publications

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“…In this study, it was found that MLR was correlated with pathological stage, differentiation degree, and M stage, which means that a worse the prognosis of patients, so the results of Zhai and Chen's study are contrary to the results of our study [15]. However, the results of this study and MLR value are similar to MLR's correlation in ovarian cancer [16], colorectal cancer [17], lung cancer [18], and other cancers, so our finding needs to be further demonstrated by multi-center and big data research. The PLR value represents the change between platelets and lymphocytes, and an increase in PLR value indicates the weakening of the anti-tumor function mediated by lymphocytes, Int J Clin Exp Pathol 2024;17(5):165-172 which is conducive to the growth and metastasis of tumor [12,19].…”

Section: Discussioncontrasting

confidence: 67%

Characterization of blood inflammatory markers in patients with non-small cell lung cancer

Zhai

2024

Int J Clin Exp Pathol

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Objective: To investigate the differences and correlation between blood inflammatory indexes such as monocytes (MONO), lymphocytes (LYM), haemoglobin (HGB), neutrophils (NEU), platelets (PLT), ultrasensitive Creactive protein, albumin and platelet/lymphocyte ratio (PLR), NEU/LYM ratio (NLR), MONO/LYM ratio (MLR) and clinicopathologic characteristics of patients with non-small cell lung cancer (NSCLC). Methods: 187 patients with NSCLC who were first diagnosed in 2017-2023 and 102 with healthy check-ups during the same period (control group) were retrospectively selected as study subjects to compare the differences in inflammatory indexes between the two groups and the levels of inflammatory indexes in NSCLC patients with different clinicopathologic characteristics. Results: Correlation analysis between blood inflammatory indexes and clinicopathologic features in NSCLC group showed that C-reactive protein, CAR, and PLR values were different in different pathologic types (P<0.05). The values of NEU, MONO, C-reactive protein, MLR, NLR, CAR and albumin were different among various degrees of differentiation (P<0.05). There were differences in LYM, albumin, MLR, NLR, CAR, and C-reactive protein among M stage subgroups (P<0.05). Analysis of the efficacy of early diagnosis of non-small cell lung cancer has been shown, the AUC of NLR was 0.796, sensitivity of 0.679, specificity of 0.176, 95% CI=0.743-0.849 (P<0.001). The AUC of albumin was 0.977, the sensitivity was 0.941, the specificity was 0.941, and 95% CI was 0.959-0.994 (P<0.001). Conclusion: Blood inflammatory indexes are closely associated with NSCLC and vary according to pathologic features. Blood inflammatory indices can predict tumor pathologic staging and guide treatment for patients with NSCLC.

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Section: Discussioncontrasting

confidence: 67%

Characterization of blood inflammatory markers in patients with non-small cell lung cancer

Zhai

2024

Int J Clin Exp Pathol

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“…Guo et al evaluated patients with unresectable stage III NSCLC and showed NPS to be an independent prognostic factor for both DFS and OS [37]. Similar results were obtained by Zou et al, who studied NPS in patients with locally advanced NSCLC following neoadjuvant therapy [38]. Both studies included inoperable patients with locally advanced disease.…”

Section: Discussionmentioning

confidence: 68%

The Naples Prognostic Score Is a Useful Tool to Assess Surgical Treatment in Non-Small Cell Lung Cancer

Elia,

Patirelis,

Hardavella

et al. 2023

Diagnostics

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Different prognostic scores have been applied to identify patients with non-small cell lung cancer who have a higher probability of poor outcomes. In this study, we evaluated whether the Naples Prognostic Score, a novel index that considers both inflammatory and nutritional values, was associated with long-term survival. This study presents a retrospective propensity score matching analysis of patients who underwent curative surgery for non-small cell lung cancer from January 2016 to December 2021. The score considered the following four pre-operative parameters: the neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, serum albumin, and total cholesterol. The Kaplan–Meier method and Cox regression analysis were performed to evaluate the relationship between the score and disease-free survival, overall survival, and cancer-related survival. A total of 260 patients were selected for the study, though this was reduced to 154 after propensity score matching. Post-propensity Kaplan–Meier analysis showed a significant correlation between the Naples Prognostic Score, overall survival (p = 0.018), and cancer-related survival (p = 0.007). Multivariate Cox regression analysis further validated the score as an independent prognostic indicator for both types of survival (p = 0.007 and p = 0.010, respectively). The Naples Prognostic Score proved to be an easily achievable prognostic factor of long-term survival in patients with non-small cell lung cancer after surgical treatment.

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Associations of Naples Prognostic Score with Stroke and all-cause mortality in adults : evidence from NHANES (2005-2018)

Xu,

Pei,

Yang

et al. 2024

Preprint

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Objective This study seeks to assess the associations of Naples Prognostic Score with stroke and all-cause mortality in adults. Methods We analyzed data from 44,601 participants in the 2005–2018 National Health and Nutrition Examination Survey (NHANES). The Naples Prognostic Score (NPS) was derived from total cholesterol, serum albumin, neutrophil-to-lymphocyte ratio (NLR), and lymphocyte-to-monocyte ratio (LMR). Participants were classified into three groups based on their NPS. Stroke incidence was determined through self-reported questionnaires, and mortality data were diligently tracked using the National Death Index. We investigated the relationship between NPS and stroke prevalence using multiple logistic regression analysis. To explore the association between NPS and all-cause mortality in stroke survivors, we applied Kaplan-Meier survival analysis and Cox proportional hazards models. Furthermore, we conducted a detailed subgroup analysis to assess interaction effects on all-cause mortality risk within this population. Results The median age of the participants was 50.00 years [interquartile range: 35.00–64.00], with males comprising 49.36% of the study. The overall stroke prevalence was 3.93%. Participants were categorized into three groups based on their NPS: 6,328 (18.1%) in Group 0 (NPS 0), 24,015 (68.8%) in Group 1 (NPS 1 or 2), and 4,580 (13.1%) in Group 2 (NPS 3 or 4). After adjusting for covariates, individuals in Group 2 exhibited a significantly higher stroke prevalence compared to Group 0, with an odds ratio (OR) of 1.83 [95% confidence interval: 1.49–2.26]. Among the 1,372 patients with a history of stroke, with a median follow-up duration of 5.94 years, we utilized Cox proportional hazards models to assess the relationship between NPS and all-cause mortality risk. The analysis revealed that, after adjusting for covariates, stroke patients in Group 2 faced a significantly elevated risk of all-cause mortality (hazard ratio [HR] = 2.08 [95% confidence interval: 1.40–3.09]) compared to those in Group 0. Subsequent subgroup analyses to explore interaction effects on all-cause mortality risk among stroke patients shown no significant interactions (p for interaction > 0.05). Conclusions This study establishes the associations of Naples Prognostic Score with stroke and all-cause mortality in adults.

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Naples Prognostic Score as an Independent Predictor of Survival Outcomes for Resected Locally Advanced Non-Small Cell Lung Cancer Patients After Neoadjuvant Treatment

Cited by 4 publications

References 60 publications

Characterization of blood inflammatory markers in patients with non-small cell lung cancer

Characterization of blood inflammatory markers in patients with non-small cell lung cancer

The Naples Prognostic Score Is a Useful Tool to Assess Surgical Treatment in Non-Small Cell Lung Cancer

Associations of Naples Prognostic Score with Stroke and all-cause mortality in adults : evidence from NHANES (2005-2018)

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