Naples Prognostic Score, Based on Nutritional and Inflammatory Status, is an Independent Predictor of Long-term Outcome in Patients Undergoing Surgery for Colorectal Cancer

Galizia, Gennaro; Lieto, Eva; Auricchio, A; Cardella, Francesca; Mabilia, Andrea; Podzemny, Vlasta; Castellano, Paolo; Orditura, Michele; Napolitano, Vincenzo

doi:10.1097/dcr.0000000000000961

Cited by 144 publications

(180 citation statements)

References 30 publications

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“…The definition of NPS was based on the following four parameters, namely serum albumin, total cholesterol (TC), LMR, and NLR. As previously reported by Gennaro Galizia et al [31], the cut-off values were 4 mg/dL for serum albumin, 180 mg/dL for TC, 2.96 for NLR, and 4.44 for LMR, respectively. Patients with serum albumin, TC or LMR lower than 4 mg/dL, 180 mg/dL, and 4.44 got one point; otherwise, they got zero point.…”

Section: Data Collection and Nps Definitionsupporting

confidence: 69%

“…Therefore, multidimensional prognostic evaluating systems which incorporate multiple prognostic factors together may be better than predictors based on single prognostic factor. Recently, a comprehensive prognostic score, the Naples prognostic score (NPS), calculated from serum albumin and total cholesterol concentrations, LMR and NLR, was reported to be a powerful prognostic index for colorectal cancer (CRC) [31]. NPS is a comprehensive scoring system which includes all of the markers that have been predominantly used now.…”

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confidence: 99%

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Prognostic value of pre-treatment Naples prognostic score (NPS) in patients with osteosarcoma

et al. 2020

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Background: This study aimed to evaluate the clinical significance of pre-treatment Naples prognostic score (NPS) in patients with osteosarcoma. Methods: The clinical data of 133 osteosarcoma patients between January 2011 and February 2018 in our hospital was retrospectively collected and analyzed. NPS was calculated from four parameters, including serum albumin level, serum total cholesterol (TC), lymphocyte-to-monocyte ratio (LMR), and neutrophil-to-lymphocyte ratio (NLR). Patients were divided into three groups (group 1-3) based on NPS. The relationships between NPS and clinical features, overall survival (OS), and progression-free survival (PFS) were analyzed. Two prediction models based on NPS and clinical parameters were developed: clinical parameters model (model A), and the combined model of NPS and clinical parameters (model B). Their predictive performances were further evaluated and compared. Results: The median follow-up time of this cohort was 46.0 (range, 5-75) months, while the median OS and PFS was 40 (range, 5-75) months and 36 (range, 5-71) months, respectively. NPS was significantly correlated with gender, tumor location, Enneking stage, pathological fracture, local recurrence, and metastasis (all P < 0.05). Variables of NPS, Enneking stage, local recurrence, metastasis, and NLR were confirmed as independent prognostic factors for OS and PFS by univariate and multivariate Cox analysis. Prediction model B obtained larger AUCs for OS and PFS and showed better consistency between nomogram-predicted and actual survival than that of model A at the follow-up time of 1-, 3-, and 5-year. Conclusions: NPS was a novel, reliable, and multidimensional prognostic scoring system with favorable predictive performance for patients with osteosarcoma.

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Section: Data Collection and Nps Definitionsupporting

confidence: 69%

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confidence: 99%

Prognostic value of pre-treatment Naples prognostic score (NPS) in patients with osteosarcoma

et al. 2020

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“…A recent study in patients with cancer has shown that hypoalbuminemia reflects the condition of malnutrition and immunosuppression, and it is at an increased risk of disease severity, tumor progression, and poor prognosis [ 23 ]. Furthermore, serum Alb level has also been widely used in various prognostic indexes, including a prognostic nutritional index (PNI) [ 24 ], a systematic inflammation index (IPI) [ 25 ], and Naples prognostic score (NPS) [ 26 ]. Serum Alb plays important roles in colloid osmotic pressure maintenance, free radical scavenging, and capillary membrane permeability alteration [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Early decrease in postoperative serum albumin predicts severe complications in patients with colorectal cancer after curative laparoscopic surgery

Wang

Jiang

et al. 2018

World J Surg Onc

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BackgroundPostoperative severe complications are always associated with prolonged hospital stays, increased economic burdens, and poor prognoses in patients with colorectal cancer (CRC). This present study aimed to investigate potential risk factors including serum albumin (Alb) for severe complications in CRC patients.MethodsEligible patients with primary CRC undergoing elective laparoscopic colectomy from July 2015 to July 2017 were included. Postoperative severe complications were defined as grade III and IV according to the Clavien–Dindo classification. ∆Alb was defined as (preoperative Alb − nadir Alb within POD2)/preoperative Alb × 100%. The baseline characteristics, intraoperative data, and laboratory data were obtained from the database for the analysis. Univariate and multivariate logistic regression analyses were utilized for the assessment of the association between risk factors and postoperative severe complications. The predictive value of ∆Alb for postoperative severe complications was evaluated by receiver operating characteristic (ROC) curve analysis.ResultsA total of 193 patients were finally included in the analysis data set, of which 38 (19.7%) patients had postoperative severe complications. In the final multivariate logistic regression analysis, ∆Alb was the only independent factor associated with postoperative severe complications (OR 1.66, 95%CI 1.18–2.33, p = 0.003). The area under the curve (AUC) of ∆Alb was 0.916, with the sensitivity and specificity of 0.842 and 0.858 (p < 0.001).ConclusionsThe ∆Alb was an independent risk factor for severe complications in CRC patients after curative laparoscopic surgery.

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“…The impact of the CONUT score on outcomes in patients undergoing surgery for colorectal cancer (CRC) was first reported in 2015 [9]. Since then, it has been further examined, and the efficiency of the CONUT score on outcomes in CRC was demonstrated [10,11]. However, most of these studies had relatively small sample sizes, variance in tumor stage and results that were not uniform.…”

Section: Introductionmentioning

confidence: 99%

Prognostic significance of the controlling nutritional status (CONUT) score in patients with colorectal cancer: A systematic review and meta-analysis

Takagi

Buettner

IJzermans

2020

International Journal of Surgery

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Background: The clinical evidence of the controlling nutritional status (CONUT) score for outcomes has increased in gastroenterological surgical oncology. The aim of this study was to investigate the impact of the CONUT score on outcomes in patients with colorectal cancer (CRC). Methods: A literature review was systematically conducted to evaluate the significance of the CONUT score in CRC patients. Meta-analyses of survival were performed to investigate the effects of the CONUT score in CRC patients. Results: Nine studies met the inclusion criteria, and six studies with 2601 patients were included in the present meta-analyses. High CONUT score was associated with poor overall survival (HR 1.97, 95%CI = 1.40-2.77, P < 0.001), cancer-specific survival (HR 3.64, 95%CI = 1.96-6.75, P < 0.001), and recurrence/relapse-free survival (HR 1.68, 95%CI = 1.23-2.29, P = 0.001) after CRC surgery. Conclusions: The CONUT score is a practical prognostic factor associated with prognosis of CRC. Further studies are needed to clarify the significance of the CONUT score in CRC patients.

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Naples Prognostic Score, Based on Nutritional and Inflammatory Status, is an Independent Predictor of Long-term Outcome in Patients Undergoing Surgery for Colorectal Cancer

Abstract: The Naples prognostic score is a simple tool strongly associated with long-term outcome in patients undergoing surgery for colorectal cancer. See Video Abstract at http://links.lww.com/DCR/A469.

Cited by 144 publications

References 30 publications

Prognostic value of pre-treatment Naples prognostic score (NPS) in patients with osteosarcoma

Prognostic value of pre-treatment Naples prognostic score (NPS) in patients with osteosarcoma

Early decrease in postoperative serum albumin predicts severe complications in patients with colorectal cancer after curative laparoscopic surgery

Prognostic significance of the controlling nutritional status (CONUT) score in patients with colorectal cancer: A systematic review and meta-analysis

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