Napsin A is a highly sensitive marker for nephrogenic adenoma: an immunohistochemical study with a specificity test in genitourinary tumors

Sharifai, Nima; Abro, Brooj; Chen, Jie‐Fu; Zhao, Ming; He, Huiying; Cao, Dengfeng

doi:10.1016/j.humpath.2020.05.007

Cited by 10 publications

(22 citation statements)

References 37 publications

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“…[ 21 , 22 ] A new study found that Napsin A was a highly sensitive marker of NA, and it could be used as a useful auxiliary marker of PAX8 when diagnosing NA. [ 23 ] For the differential diagnosis of NA, the combined detection of PAX8 + , p63 - , and EMA + could distinguish NA from the most common urothelial and prostate carcinoma. [ 24 ] In addition, Napsin A combined with PAX8 was found to have a high specificity for the differential diagnosis of NA from simple urothelial carcinoma and prostate cancer.…”

Section: Discussionmentioning

confidence: 99%

“…[ 24 ] In addition, Napsin A combined with PAX8 was found to have a high specificity for the differential diagnosis of NA from simple urothelial carcinoma and prostate cancer. [ 23 ] It was confirmed that the combined detection of immune markers AMACR, CK903, and P63 could reduce the possibility of NA being misdiagnosed as prostatic adenocarcinoma. [ 25 ] GATA3 is a sensitive and specific marker for urothelial carcinoma and can distinguish NA from other tumors in the differential diagnosis.…”

Section: Discussionmentioning

confidence: 99%

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Nephrogenic adenoma of the renal pelvis

Zhang¹,

Wu²,

Sun³

et al. 2021

Medicine

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Rationale: Nephrogenic adenoma (NA) is a rare benign lesion of the urinary tract, which rarely occurs in the renal pelvis. Only 19 cases have been reported in the literature. However, there is no detailed report on the clinicopathological features of NA of the renal pelvis. Patient concerns: This case report describes a 46-year-old male patient who was admitted to the hospital for one month because of painless gross hematuria with blood clots. He had a history of hyperuricemia and a family history of gastric cancer. Diagnoses: NA of the renal pelvis was diagnosed pathologically and immunohistochemical. Interventions: The patient underwent laparoscopic nephroureterectomy. Outcomes: The patient recovered well after the operation with no discomfort. In addition, we followed up with the patient regularly post-discharge (approximately 20 months). There were no obvious abnormalities in the results of routine urine culture, computed tomography scan of the abdomen, and cystoscopy during the follow-up period, and the symptoms disappeared completely and did not recur. Lessons: NA of the renal pelvis is extremely rare in the clinic, which can be easily misdiagnosed and overtreated. However, for pathological diagnosis of this disease, specific immunohistochemical staining for preoperative biopsy was reported to be significant, which should be considered by the urologists and pathologists.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Nephrogenic adenoma of the renal pelvis

Zhang¹,

Wu²,

Sun³

et al. 2021

Medicine

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“…The combined expression of PAX-8 and absence of p63 and GATA-3 should solve difficult cases [16]. Very recently, napsin A has been proposed as a sensitive marker in NA useful as well in the differential diagnosis [18].…”

Section: Nephrogenic Adenoma (Na)mentioning

confidence: 99%

Mimickers of Urothelial Carcinoma and the Approach to Differential Diagnosis

Manini

Angulo

López

2021

Clinics and Practice

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A broad spectrum of lesions, including hyperplastic, metaplastic, inflammatory, infectious, and reactive, may mimic cancer all along the urinary tract. This narrative collects most of them from a clinical and pathologic perspective, offering urologists and general pathologists their most salient definitory features. Together with classical, well-known, entities such as urothelial papillomas (conventional (UP) and inverted (IUP)), nephrogenic adenoma (NA), polypoid cystitis (PC), fibroepithelial polyp (FP), prostatic-type polyp (PP), verumontanum cyst (VC), xanthogranulomatous inflammation (XI), reactive changes secondary to BCG instillations (BCGitis), schistosomiasis (SC), keratinizing desquamative squamous metaplasia (KSM), post-radiation changes (PRC), vaginal-type metaplasia (VM), endocervicosis (EC)/endometriosis (EM) (müllerianosis), malakoplakia (MK), florid von Brunn nest proliferation (VB), cystitis/ureteritis cystica (CC), and glandularis (CG), among others, still other cellular proliferations with concerning histological features and poorly understood etiopathogenesis like IgG4-related disease (IGG4), PEComa (PEC), and pseudosarcomatous myofibroblastic proliferations (post-operative spindle cell nodule (POS), inflammatory myofibroblastic tumor (IMT)), are reviewed. Some of these diagnoses are problematic for urologists, other for pathologists, and still others for both. Interestingly, the right identification of their definitory features will allow their correct diagnoses, thus, avoiding overtreatment. The literature selected for this review also focuses on the immunohistochemical and/or molecular data useful to delineate prognosis.

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“…The bland cytologic features of this histologic subtype contrast with its frank infiltrative nature, even reaching the muscularis propria in some cases. Since nephrogenic adenoma may display also a concerning pseudo-infiltrative growth [28], an immunohistochemical study with PAX-8, CK7, p63, and napsin A [29] may be useful to make the differential diagnosis in problematic cases. The clinical significance of this histologic change is not established so far.…”

Section: Small Tubules and Nephrogenic Adenoma-like Architecturementioning

confidence: 99%

Unusual Faces of Bladder Cancer

Manini

López

2020

Cancers

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The overwhelming majority of bladder cancers are transitional cell carcinomas. Albeit mostly monotonous, carcinomas in the bladder may occasionally display a broad spectrum of histological features that should be recognized by pathologists because some of them represent a diagnostic problem and/or lead prognostic implications. Sometimes these features are focal in the context of conventional transitional cell carcinomas, but some others are generalized across the tumor making its recognition a challenge. For practical purposes, the review distributes the morphologic spectrum of changes in architecture and cytology. Thus, nested and large nested, micropapillary, myxoid stroma, small tubules and adenoma nephrogenic-like, microcystic, verrucous, and diffuse lymphoepithelioma-like, on one hand, and plasmacytoid, signet ring, basaloid-squamous, yolk-sac, trophoblastic, rhabdoid, lipid/lipoblastic, giant, clear, eosinophilic (oncocytoid), and sarcomatoid, on the other, are revisited. Key histological and immunohistochemical features useful in the differential diagnosis are mentioned. In selected cases, molecular data associated with the diagnosis, prognosis, and/or treatment are also included.

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Napsin A is a highly sensitive marker for nephrogenic adenoma: an immunohistochemical study with a specificity test in genitourinary tumors

Cited by 10 publications

References 37 publications

Nephrogenic adenoma of the renal pelvis

Nephrogenic adenoma of the renal pelvis

Mimickers of Urothelial Carcinoma and the Approach to Differential Diagnosis

Unusual Faces of Bladder Cancer

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