Naringin regulates erectile dysfunction by abolition of apoptosis and inflammation through NOS/cGMP/PKG signalling pathway on exposure to Bisphenol-A in hypertensive rat model

Akintunde, J. K.; Akintola, T.E.; Aliu, F.H.; Fajoye, M.O.; Adimchi, S.O.

doi:10.1016/j.reprotox.2020.05.007

Cited by 27 publications

(18 citation statements)

References 59 publications

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“…25−28 Decrease in NOS is also thought to elicit oxidative stress and inflammation. 29,30 In this study, the blood pressure did not change in the L-OHP group. As per the results of the study, L-OHP might have reduced NOS activation in the corpus cavernosum, but the blood pressure may have been maintained by some alternative…”

Section: Discussionmentioning

confidence: 49%

Oxaliplatin, an Anticancer Agent, Causes Erectile Dysfunction in Rats due to Endothelial Dysfunction

Kataoka

Mori

Suzuki

et al. 2021

The Journal of Sexual Medicine

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Background: Chemotherapeutics, one of the standard treatment options for cancer worldwide, have various adverse effects, including erectile dysfunction (ED). Aim: To investigate erectile function in an animal model after administration of the anticancer agent oxaliplatin (L-OHP). Methods: Male Wistar/ST rats were divided into 2 groups: L-OHP rats (n = 21), which were intravenously administered L-OHP (4 mg/kg; twice a week for 4 weeks), and Control rats (n = 21), which were injected with the same volume of 5% glucose solution, using the same dosing schedule. At the end of the study period, erectile function was evaluated by measuring intracavernous pressure (ICP) and mean arterial pressure (MAP) after cavernous nerve stimulation (n = 9−10). Endothelial function was evaluated with an isometric tension study using corpus cavernosum strips (n = 11). Western blot analysis was used to assess neuronal nitric oxide (nNOS) and endothelial NO synthase (eNOS) protein levels (n = 7). Real-time quantitative polymerase chain reaction (qRT-PCR) was used to assess the expression of inflammation-and oxidative stress-related markers (nicotinamide adenine dinucleotide phosphate oxidase-1, p22 phox , interleukin [IL]-6, and nuclear factor-kappa B) (n = 6). Statistical significance was determined using the Student's t-test. Outcomes: The L-OHP group had a significantly lower ICP:MAP ratio than the control group (P < .05). Compared to the Control group, the L-OHP group exhibited significantly lower responses to ACh and eNOS protein levels and significantly higher inflammatory biomarker levels. Clinical Translation: The results based on this animal model indicate that use of the anticancer agent L-OHP should be considered as a risk factor for ED occurring via reduction of NO bioavailability in humans; our results provide possible treatment strategies for maintaining the erectile function of cancer survivors. Strengths and limitations: Our study showed that the anticancer agent L-OHP has the propensity to cause ED in rats. A major limitation of this study is the lack of an established cure for ED associated with L-OHP and the lack of clinical evidence. Conclusions: L-OHP causes ED in rats via reduction of NO bioavailability caused by endothelial dysfunction.

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Section: Discussionmentioning

confidence: 49%

Oxaliplatin, an Anticancer Agent, Causes Erectile Dysfunction in Rats due to Endothelial Dysfunction

Kataoka

Mori

Suzuki

et al. 2021

The Journal of Sexual Medicine

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“…Anomalies in the purinergic signaling have been shown to contribute to ED majorly through decreased ATP facilitated cavernosal relaxation (Hupertan et al, 2012;Wen & Xia, 2012). The increase in ATP hydrolyzing enzymes and adenosine deaminase when L-NAME was administered to the rats in this study is indicative of low cellular energy in the penis leading to ED (Akintunde et al, 2020). The results of this study also showed that the citrus juices reduced the breakdown ATP and ADP and boosted NO production in the rats with ED which translated to a corresponding increase in sexual behavior compared to the rats without treatment.…”

Section: Effect Of the Juices On Enzymes Linked With Erectile Functionsupporting

confidence: 51%

“…Similar to other results in this study the combination of lime (1.0 ml/kg) and sildenafil had synergistic effect on the inhibition of the purinergic enzymes when compared to the other juices. This result carries further significance as adenosine has been established to portray similar functions to NO and cGMP as a potent vasodilator (Akintunde et al, 2020).…”

Section: Effect Of the Juices On Enzymes Linked With Erectile Functionmentioning

confidence: 80%

Influence of lemon ( Citrus limon ) and lime ( Citrus aurantifolia ) juices on the erectogenic properties of sildenafil in rats with L‐NAME‐induced erectile dysfunction

Ademosun

Mohammed

Oboh

et al. 2022

Journal of Food Biochemistry

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The use of lemon (Citrus limon) and lime (Citrus aurantifolia) juices for the treatment of erectile dysfunction (ED) is fast becoming common practice, even though there is dearth of information on the effect of such functional food and drug combination in the management of ED. This study evaluated the effect of lemon and lime juices on the erectogenic properties of sildenafil. ED was induced with L-NAME (40 mg/kg body weight). The rats were divided into 11 groups (n = 6) and given various doses of the test samples. Immediately after the sexual behavior studies, the animals were sacrificed and the penile and brain tissues were isolated. The results revealed that lime How to cite this article: Ademosun, A. O., Mohammed, A., Oboh, G., & Ajeigbe, O. F. (2022). Influence of lemon (Citrus limon) and lime (Citrus aurantifolia) juices on the erectogenic properties of sildenafil in rats with L-NAME-induced erectile dysfunction.

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“…Naringin inhibits the expression of TNF-α and IL-1β, the expression of which is increased by BPA [ 146 , 148 ]. They are pro-inflammatory cytokines that are secreted by macrophages of the M1 type and are involved in the regulation and expression of various genes that play key roles in oncogenesis and the inflammatory process.…”

Section: Survey Of Antioxidants That Affected Bpa Toxicitymentioning

confidence: 99%

“…Since it stains granulocytes and their precursors, it is also an effective marker of myeloid tumors. The reduction of apoptotic proteins (caspace-9 and p53) caused cGMP self-stimulation during smooth muscle relaxation [ 148 ].…”

Section: Survey Of Antioxidants That Affected Bpa Toxicitymentioning

confidence: 99%

Can Antioxidants Reduce the Toxicity of Bisphenol?

2022

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BPA is still the subject of extensive research due to its widespread use, despite its significant toxicity resulting not only from its negative impact on the endocrine system but also from disrupting the organism’s oxidative homeostasis. At the molecular level, bisphenol A (BPA) causes an increased production of ROS and hence a change in the redox balance, mitochondrial dysfunction, and modulation of cell signaling pathways. Importantly, these changes accumulate in animals and humans, and BPA toxicity may be aggravated by poor diet, metabolic disorders, and coexisting diseases. Accordingly, approaches using antioxidants to counteract the negative effects of BPA are being considered. The preliminary results that are described in this paper are promising, however, it should be emphasized that further studies are required to determine the optimal dosage and treatment regimen to counteract BPA toxicity. It also seems necessary to have a more holistic approach showing, on the one hand, the influence of BPA on the overall human metabolism and, on the other hand, the influence of antioxidants in doses that are acceptable with the diet on BPA toxicity. This is due in part to the fact that in many cases, the positive effect of antioxidants in in vitro studies is not confirmed by clinical studies. For this reason, further research into the molecular mechanisms of BPA activity is also recommended.

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Naringin regulates erectile dysfunction by abolition of apoptosis and inflammation through NOS/cGMP/PKG signalling pathway on exposure to Bisphenol-A in hypertensive rat model

Cited by 27 publications

References 59 publications

Oxaliplatin, an Anticancer Agent, Causes Erectile Dysfunction in Rats due to Endothelial Dysfunction

Oxaliplatin, an Anticancer Agent, Causes Erectile Dysfunction in Rats due to Endothelial Dysfunction

Influence of lemon ( Citrus limon ) and lime ( Citrus aurantifolia ) juices on the erectogenic properties of sildenafil in rats with L‐NAME‐induced erectile dysfunction

Can Antioxidants Reduce the Toxicity of Bisphenol?

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