Narrowband ultraviolet B course improves vitamin D balance in women in winter

Vähävihu, Katja; Ylianttila, Lasse; Kautiainen, Hannu; Viljakainen, Heli; Lamberg‐Allardt, Christel; Hasan, Taina; Tuohimaa, Pentti; Reunala, Timo; Snellman, Erna

doi:10.1111/j.1365-2133.2010.09629.x

Cited by 33 publications

(44 citation statements)

References 27 publications

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“…The geographic location and careful seasonal timing of our study caused our subjects to have low levels of 25(OH)D at the baseline visit, although defining what constitutes deficiency is controversial. 30 We showed that 25(OH)D increases rapidly with narrowband UV-B, in agreement with previous studies 17,18,[33][34][35] We also noted that the increments of 25(OH)D became successively smaller with successive visits, an effect that has been noted before and is partly due to UV light also having a catabolic effect on the vitamin. 36 In addition, the majority of our subjects started with lower levels of CD3 1 CD4 1 CD25 hi FoxP3 1 Treg cells than those previously reported, 37,38 although proportions in different studies are difficult to compare due to variation in methodology.…”

Section: Discussionsupporting

confidence: 90%

Effects of ultraviolet light on human serum 25-hydroxyvitamin D and systemic immune function

Milliken

Wassall

Lewis

et al. 2012

Journal of Allergy and Clinical Immunology

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Section: Discussionsupporting

confidence: 90%

Effects of ultraviolet light on human serum 25-hydroxyvitamin D and systemic immune function

Milliken

Wassall

Lewis

et al. 2012

Journal of Allergy and Clinical Immunology

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“…Though a few studies show that NBUVB increases circulating levels of 25-hydroxy vitamin D [21, 22], there is yet no published study comparing the levels of 25(OH)D in patients of vitiligo before and after NBUVB phototherapy and correlating it with repigmentation.…”

Section: Discussionmentioning

confidence: 99%

Correlation of Vitamin D Levels with Pigmentation in Vitiligo Patients Treated with NBUVB Therapy

et al. 2014

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Cholecalciferol (vitamin D) might play a physiological role in photo-induced melanogenesis in human skin. We estimated the levels of 25-hydroxy vitamin D [25(OH)D] before, during, and after Narrow Band Ultraviolet B (NBUVB) radiation in patients of vitiligo and their correlation with NBUVB induced pigmentation. Thirty patients of vitiligo and equal number of age and sex matched controls were recruited for the study. Vitiligo patients were treated with NBUVB thrice weekly for 12 weeks. [25(OH)D] levels and Vitiligo Area and Severity Index (VASI) were calculated at 0 (baseline), 6, and 12 weeks. Baseline [25(OH)D] levels were measured in controls. Significant reduction in VASI score was observed after 12 weeks of therapy. Comparison and correlation between mean improvement in VASI and [25(OH)D] levels at 12 weeks showed moderate correlation, and the results were statistically insignificant. Mean reduction in VASI and increase in [25(OH)D] levels after 12 weeks of NBUVB showed moderate correlation. Thus, vitamin D might play a significant role in photo-induced melanogenesis. However, there might be additional effects of the phototherapy on melanogenesis. The complete mechanism of NBUVB induced pigmentation in vitiligo needs to be elucidated.

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“…Many participants demonstrated a rapid rise in [25(OH)D] during the first week, which is similar to the response to an acute dose of ultraviolet radiation exposure [25]; but distinct from the more gradual effects of other forms of exogenous vitamin D intake (e.g., oral D2 ingestion [10]). Several non-pregnant participants demonstrated peak [25(OH)D] as early as two days after supplement delivery, and there was notably wider variability in responses in the group of non-pregnant participants during the early escalation phase compared to pregnant participants.…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics of a single oral dose of vitamin D3 (70,000 IU) in pregnant and non-pregnant women

Roth

Mahmud

Raqib

et al. 2012

Nutr J

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BackgroundImprovements in antenatal vitamin D status may have maternal-infant health benefits. To inform the design of prenatal vitamin D3 trials, we conducted a pharmacokinetic study of single-dose vitamin D3 supplementation in women of reproductive age.MethodsA single oral vitamin D3 dose (70,000 IU) was administered to 34 non-pregnant and 27 pregnant women (27 to 30 weeks gestation) enrolled in Dhaka, Bangladesh (23°N). The primary pharmacokinetic outcome measure was the change in serum 25-hydroxyvitamin D concentration over time, estimated using model-independent pharmacokinetic parameters.ResultsBaseline mean serum 25-hydroxyvitamin D concentration was 54 nmol/L (95% CI 47, 62) in non-pregnant participants and 39 nmol/L (95% CI 34, 45) in pregnant women. Mean peak rise in serum 25-hydroxyvitamin D concentration above baseline was similar in non-pregnant and pregnant women (28 nmol/L and 32 nmol/L, respectively). However, the rate of rise was slightly slower in pregnant women (i.e., lower 25-hydroxyvitamin D on day 2 and higher 25-hydroxyvitamin D on day 21 versus non-pregnant participants). Overall, average 25-hydroxyvitamin D concentration was 19 nmol/L above baseline during the first month. Supplementation did not induce hypercalcemia, and there were no supplement-related adverse events.ConclusionsThe response to a single 70,000 IU dose of vitamin D3 was similar in pregnant and non-pregnant women in Dhaka and consistent with previous studies in non-pregnant adults. These preliminary data support the further investigation of antenatal vitamin D3 regimens involving doses of ≤70,000 IU in regions where maternal-infant vitamin D deficiency is common.Trial registrationClinicalTrials.gov (NCT00938600)

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Narrowband ultraviolet B course improves vitamin D balance in women in winter

Abstract: NB-UVB exposures given on seven consecutive days on different skin areas of healthy women significantly improved serum calcidiol concentration. A short low-dose NB-UVB course can improve vitamin D balance in winter.

Cited by 33 publications

References 27 publications

Effects of ultraviolet light on human serum 25-hydroxyvitamin D and systemic immune function

Effects of ultraviolet light on human serum 25-hydroxyvitamin D and systemic immune function

Correlation of Vitamin D Levels with Pigmentation in Vitiligo Patients Treated with NBUVB Therapy

Pharmacokinetics of a single oral dose of vitamin D3 (70,000 IU) in pregnant and non-pregnant women

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