Narrowing down the common deleted region of 5q to 6.0 Mb in blastic plasmacytoid dendritic cell neoplasms

Fu, Yumei; Fesler, Mark; Mahmud, Gibran; Bernreuter, Kristen; Jia, Dongmei; Batanian, Jacqueline R.

doi:10.1016/j.cancergen.2013.07.002

Cited by 20 publications

(11 citation statements)

References 22 publications

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“…One patient died before the start of treatment. The survival time after diagnosis ranged from 16 days to 26 months for the eight patients who died …”

Section: Resultsmentioning

confidence: 99%

“…4 The t(6;8)(p21;q24) translocation has been reported in other types of malignancy, including follicular lymphoma and acute myeloid leukaemia. 8 Additionally, MYC rearrangements in B-cell lymphomas with a simple karyotype, such as Burkitt lymphomas, are known to respond better to chemotherapy, whereas those with a complex karyotype, such as high-grade B-cell lymphoma with MYC rearrangement and either bcl-2 or bcl-6 translocations, show a very poor clinical outcome, and are refractory to chemotherapy and stem cell transplantation. 21 In our study, when the karyotype was reported, all cases showed a complex karyotype (8/8), indicating that t(6;8)(p21;q24), when accompanied by a complex karyotype, could be related to tumour progression.…”

Section: Discussionmentioning

confidence: 99%

“…The survival time after diagnosis ranged from 16 days to 26 months for the eight patients who died. [5][6][7][8][9][10][11][12][13][14][15]…”

Section: Casementioning

confidence: 99%

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An analysis of blastic plasmacytoid dendritic cell neoplasm with translocations involving the MYC locus identifies t(6;8)(p21;q24) as a recurrent cytogenetic abnormality

et al. 2018

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“…One patient died before the start of treatment. The survival time after diagnosis ranged from 16 days to 26 months for the eight patients who died …”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

An analysis of blastic plasmacytoid dendritic cell neoplasm with translocations involving the MYC locus identifies t(6;8)(p21;q24) as a recurrent cytogenetic abnormality

et al. 2018

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“…Whole-exome-sequencing analysis of three cases of blastic plasmacytoid dendritic cell neoplasms confirmed the relationship to the myeloid leukemias [44].…”

Section: Immunophenotypementioning

confidence: 65%

Blastic Plasmacytoid Dendritic Cell Neoplasm

2014

Skin Lymphoma

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Blastic plasmacytoid dendritic cell neoplasm is a rare and aggressive hematodermic neoplasia with frequent cutaneous involvement and leukemic dissemination. We report the case of a 76-year-old man with a 2 month history of violaceous nodules and a tumor with stony consistency, located on the head, and mandibular, cervical and supraclavicular lymphadenopathies. Multiple thoracic and abdominal adenopathies were identified on computerized tomography. Flow cytometry analysis of the skin, lymph node and bone marrow biopsies demonstrated the presence of plasmocytoid dendritic cell neoplastic precursor cells (CD4+, CD45+, CD56+ and CD123+ phenotype). After initial clinical and laboratorial complete remission with chemotherapy, the patient died due to relapse of the disease associated with the appearance of a cervical mass with medullary compromise. Keywords: Antigens, CD4; Antigens, CD56; Dendritic cells; Leukemia; Leukemic infiltration Resumo: A neoplasia blástica de células dendríticas plasmocitóides é uma neoplasia hematodérmica rara, agressiva, com frequente envolvimento cutâneo e disseminação leucêmica. Relatamos o caso de um homem de 76 anos com quadro clínico com 2 meses de evolução caracterizado por nódulos e tumor de tonalidade violácea, de consistência pétrea, localizados na cabeça, e linfadenopatias mandibular, cervicais e supraclaviculares. Identificaram-se múltiplas adenopatias torácicas e abdominais em tomografia computorizada. A análise por citometria de fluxo de biópsias cutânea, ganglionar e óssea demonstrou a presença de precursores neoplásicos das células dendríticas plasmocitóides (fenótipo CD4+, CD45+, CD56+ e CD123+). Após remissão clínica e laboratorial completa inicial com quimioterapia, veio a falecer por recaída da doença associada ao aparecimento de massa cervical com compromisso medular.

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“…60 The common deleted region of 5q is being examined to find candidate genes that may contribute to BPDCN oncogenesis. Genomic losses on 12p and 13q (64%), 6q (50%), 15q (43%), and monosomy 9 (28%) are well described.…”

Section: Can Genetic Markers Assist In the Diagnosis Or Clinical Manamentioning

confidence: 99%

Extramedullary Manifestations of Myeloid Neoplasms

Wilson

Medeiros

2015

American Journal of Clinical Pathology

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Narrowing down the common deleted region of 5q to 6.0 Mb in blastic plasmacytoid dendritic cell neoplasms

Cited by 20 publications

References 22 publications

An analysis of blastic plasmacytoid dendritic cell neoplasm with translocations involving the MYC locus identifies t(6;8)(p21;q24) as a recurrent cytogenetic abnormality

An analysis of blastic plasmacytoid dendritic cell neoplasm with translocations involving the MYC locus identifies t(6;8)(p21;q24) as a recurrent cytogenetic abnormality

Blastic Plasmacytoid Dendritic Cell Neoplasm

Extramedullary Manifestations of Myeloid Neoplasms

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