Nasal CD56 positive small round cell tumors

Liu, Qiang; Ohshima, Koichi; Sumie, Aiko; Suzushima, Hitoshi; Iwasaki, Hiroshi; Kikuchi, Masahiro

doi:10.1007/s004280000326

Cited by 23 publications

(4 citation statements)

References 17 publications

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“…In a tumor negative for the panel of markers proposed, CD45 should be performed to evaluate this rare possibility. Since CD56 is expressed in hematopoietic pathologies, its diagnostic value in the differentiation of neuroendocrine tumors should be kept in mind [5,39–41]. …”

Section: Discussionmentioning

confidence: 99%

Molecular and phenotypic analysis of poorly differentiated sinonasal neoplasms: an integrated approach for early diagnosis and classification

et al. 2009

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Accurate early diagnosis of poorly differentiated tumors of the sinonasal and skull-base sites is critical to modern multimodality management of patients with these tumors. A combined phenotypic and sequential biomarkers approach of a large retrospective cohort of these tumors led to the reclassification of some cases and the confirmation of uncertain diagnoses in others. An integrated algorithm of selected markers and phenotypic features for biopsy-based diagnosis of these tumors is presented and discussed. Primary poorly differentiated (small round and non-small) sinonasal neoplasms comprise histogenetically and biologically diverse entities with overlapping morphologic features. Because of the limited initial biopsy tissue materials, differential diagnostic difficulties may arise and complicate timely management of some cases. We employed immunohistochemical and molecular marker analyses in a large cohort of these tumors to optimize their early diagnosis and classification. Fifty-two tumors of the skull base and sinonasal regions and, for comparison, 19 poorly differentiated neoplasms of other head and neck sites were analyzed by a panel of immunohistochemical markers including those of epithelial, mesenchymal, melanocytic, and neuroectodermal origin using tissue microarray. RT-PCR analysis of mRNA for EWS-FLI1 and PAX-FKHR fusion transcripts and the hASH1 gene was performed on 24 of the 52 sinonasal tumors and the 19 tumors of other sites for comparison. The immunohistochemical results substantiated the phenotypic assessment and the initial diagnosis in 49 of the 52 tumors. In four instances the integrated markers and phenotypic analyses led to reclassification of three tumors and confirmed the histogenesis of a mesenchymal tumor with aberrant cytokeratin expression. Molecular analysis of the EWS-FLI1 fusion gene transcript revealed four (9.3%) of the 43 tumors to be positive; all were Ewing’s sarcomas. The hASH1 gene transcript was identified in 10 (23.8%) of 42 tumors: three of six neuroblastomas, all four neuroendocrine carcinomas, and one each in sinonasal undifferentiated carcinoma, rhabdomyosarcoma, and melanoma. The PAX-FKHR fusion transcript was not detected in any tumors. We conclude that 1) an integrated morphologic and biomarker algorithm may better optimize the early diagnosis of poorly differentiated sinonasal and skull-base tumors; 2) molecular analysis may assist in future biological stratification of certain classes of these tumors; and 3) the hASH1 gene transcript is a nonspecific marker for the diagnosis of neuroblastoma.

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Section: Discussionmentioning

confidence: 99%

Molecular and phenotypic analysis of poorly differentiated sinonasal neoplasms: an integrated approach for early diagnosis and classification

et al. 2009

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“…40,42 The expression of CD56 in these immature lymphoid neoplasms may create diagnostic confusion with other small round blue cell tumors that express CD56 including olfactory neuroblastoma, primitive neuroectodermal tumor and rhabdomyosarcoma. 41 …”

Section: Aggressive T and Nk-cell Neoplasmsmentioning

confidence: 99%

Hematolymphoid lesions of the sinonasal tract

Crane

Duffield

2016

Seminars in Diagnostic Pathology

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Summary Various hematolymphoid lesions involve the sinonasal tract, including aggressive B, T, and NK-cell neoplasms; myeloid sarcoma; low grade lymphomas; indolent T-lymphoblastic proliferations; and Rosai-Dorfman disease. Differentiating aggressive lymphomas from non-hematopoietic neoplasms such as poorly differentiated squamous cell carcinoma, olfactory neuroblastoma, or sinonasal undifferentiated carcinoma may pose diagnostic challenges. In addition, the necrosis, vascular damage and inflammatory infiltrates which are associated with some hematolymphoid disorders can result in misdiagnosis as infectious, autoimmune or inflammatory conditions. Here, we review hematolymphoid disorders involving the sinonasal tract including their key clinical and histopathologic features.

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“…Reports of flow cytometry immunophenotyping showing strong expression of CD56 in Ewing tumor/PNET are available. [9] Our case also showed strong CD56 positivity on flow cytometry immunophenotyping on bone marrow aspirate.…”

Section: Discussionmentioning

confidence: 53%

FNA diagnosis of CD99 positive neuroblastoma: A diagnostic dilemma

Kaur

Bakshi

Verma

2012

J Cytol

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Tissue diagnosis of small round cell tumors relies heavily on immunohistochemical staining. Two of the small round cell tumors, namely neuroblastoma and primitive neuroectodermal tumor, have considerable morphologic overlap. Many studies suggest that CD99 positivity virtually excludes the diagnosis of neuroblastoma. We report a case of poorly differentiated neuroblastoma in which aberrant CD99 positivity led to diagnostic dilemma.

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Nasal CD56 positive small round cell tumors

Cited by 23 publications

References 17 publications

Molecular and phenotypic analysis of poorly differentiated sinonasal neoplasms: an integrated approach for early diagnosis and classification

Molecular and phenotypic analysis of poorly differentiated sinonasal neoplasms: an integrated approach for early diagnosis and classification

Hematolymphoid lesions of the sinonasal tract

FNA diagnosis of CD99 positive neuroblastoma: A diagnostic dilemma

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