Nasal Delivery of Hesperidin/Chitosan Nanoparticles Suppresses Cytokine Storm Syndrome in a Mouse Model of Acute Lung Injury

Jin, Hua; Zhao, Zuguo; Lei, Qian; Zhou, Haotong; Mai, Zesen; Wang, Yuan; Ding, Xiaowen; Zhang, Wenting; Pi, Jiang; Evans, Colin E.; Liu, Xinguang

doi:10.3389/fphar.2020.592238

Cited by 47 publications

(33 citation statements)

References 31 publications

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“…To further investigate whether the inflammatory response caused excessive apoptosis, immunohistochemical staining was performed to detect the expression of IL-1β and caspase-1 in the lung tissue [ 52 ]. The results showed reduction in the expression of IL-1β and caspase-1 after treatment with MPSS, MPSS-CSNPs, and RBC-MPSS-CSNPs ( Fig.…”

Section: Resultsmentioning

confidence: 99%

RBC-hitchhiking chitosan nanoparticles loading methylprednisolone for lung-targeting delivery

Ding

Zheng³

et al. 2022

Journal of Controlled Release

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Hyper-inflammation associated with cytokine storm syndrome causes high mortality in patients with COVID-19. Glucocorticoids, such as methylprednisolone sodium succinate (MPSS), effectively inhibit this inflammatory response. However, frequent and chronic administration of glucocorticoids at high doses leads to hormone dependence and serious side effects. The aim of the present study was to combine nanoparticles with erythrocytes for the targeted delivery of MPSS to the lungs. Chitosan nanoparticles loading MPSS (MPSS-CSNPs) were prepared and adsorbed on the surface of red blood cells (RBC-MPSS-CSNPs) by non-covalent interaction. In vivo pharmacokinetic study indicated that RBC-hitchhiking could significantly reduce the plasma concentration of the drug and prolong the circulation time. The mean residence time (MRT) and area under the curve (AUC) of the RBC-MPSS-CSNPs group were significantly higher than those of the MPSS-CSNPs group and the MPSS injection group. Moreover, in vivo imaging and tissue distribution indicated that RBC-hitchhiking facilitated the accumulation of nanoparticles loading fluorescein in the lung, preventing uptake of these nanoparticles by the liver. Furthermore, compared with the MPSS-CSNPs and MPSS treatment groups, treatment with RBC-MPSS-CSNPs considerably inhibited the production of inflammatory cytokines such as TNF-α and IL-6, and consequently attenuated lung injury induced by lipopolysaccharide in rats. Therefore, RBC-hitchhiking is a potentially effective strategy for the delivery of nanoparticles to the lungs for the treatment of acute lung injury and acute respiratory distress syndrome.

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Section: Resultsmentioning

confidence: 99%

RBC-hitchhiking chitosan nanoparticles loading methylprednisolone for lung-targeting delivery

Ding

Zheng³

et al. 2022

Journal of Controlled Release

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“…It is worth mentioning that the hesperidin dose that had protective effects on cytokine storm syndrome-induced acute lung injury was also used in the treatment of acute respiratory distress syndrome (ARDS). 198…”

Section: Mouth Rinses Containing Citroxmentioning

confidence: 99%

Pharmacological Significance of Hesperidin and Hesperetin, Two Citrus Flavonoids, as Promising Antiviral Compounds for Prophylaxis Against and Combating COVID-19

Agrawal¹,

Agrawal²,

Blunden

2021

Natural Product Communications

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Hesperidin and hesperetin are flavonoids that are abundantly present as constituents of citrus fruits. These compounds have attracted attention as several computational methods, mostly docking studies, have shown that hesperidin may bind to multiple regions of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (spike protein, angiotensin-converting enzyme 2, and proteases). Hesperidin has a low binding energy, both with the SARS-CoV-2 “spike” protein responsible for internalization, and also with the “PLpro” and “Mpro” responsible for transforming the early proteins of the virus into the complex responsible for viral replication. This suggests that these flavonoids could act as prophylactic agents by blocking several mechanisms of viral infection and replication, and thus helping the host cell to resist viral attack.

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“…The nasal and inhaled drug deliveries are also promising approaches because these methods have the potential to improve drug delivery to lung (Jin et al, 2020). Targeted drug delivery, high efficacy, less toxicity, reduced biodistribution, enhanced bioavailability, and improved patient comfort are all advantages of using nanotechnology for drug delivery via the nasal route (Dugasa & Williams, 2016).…”

Section: Modulating Pneumonia Microenvironments By Npsmentioning

confidence: 99%

Inflammation‐modulating nanoparticles for pneumonia therapy

Muhammad

Zhai

Wang

et al. 2021

WIREs Nanomed Nanobiotechnol

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Pneumonia is a common but serious infectious disease, and is the sixth leading cause for death. The foreign pathogens such as viruses, fungi, and bacteria establish an inflammation response after interaction with lung, leading to the filling of bronchioles and alveoli with fluids. Although the pharmacotherapies have shown their great effectiveness to combat pathogens, advanced methods are under developing to treat complicated cases such as virus‐infection and lung inflammation or acute lung injury (ALI). The inflammation modulation nanoparticles (NPs) can effectively suppress immune cells and inhibit inflammatory molecules in the lung site, and thereby alleviate pneumonia and ALI. In this review, the pathological inflammatory microenvironments in pneumonia, which are instructive for the design of biomaterials therapy, are summarized. The focus is then paid to the inflammation‐modulating NPs that modulate the inflammatory cells, cytokines and chemokines, and microenvironments of pneumonia for better therapeutic effects. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Respiratory Disease

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Nasal Delivery of Hesperidin/Chitosan Nanoparticles Suppresses Cytokine Storm Syndrome in a Mouse Model of Acute Lung Injury

Cited by 47 publications

References 31 publications

RBC-hitchhiking chitosan nanoparticles loading methylprednisolone for lung-targeting delivery

RBC-hitchhiking chitosan nanoparticles loading methylprednisolone for lung-targeting delivery

Pharmacological Significance of Hesperidin and Hesperetin, Two Citrus Flavonoids, as Promising Antiviral Compounds for Prophylaxis Against and Combating COVID-19

Inflammation‐modulating nanoparticles for pneumonia therapy

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