Nasal Mucociliary Clearance and Nasal and Oral pH in Patients with Insulin-Dependent Diabetes

Abstract

We studied 32 pati ents with insulin-dependent diab etes mellitus to determine how their rate ofmucoc iliary clearance and their levels ofnasal and oral pH compared with those of 10 nondiabetic contro ls and how these rhinologic measurements varied within different subsets ofdiab etic patients. A lthough wefo und very f ew statistically significant differences in all our comparisons, we did fi nd that nasal mucociliary clearance and oral pH levels in the diabetic patients were significant ly differe ntfro m those of healthy subj ects. Fro m the Dep artment of Pediatrics, Faculty of Med ic ine, Atat ilrk Unive rsity, Erzurum, T urkey (Dr. Muk adder Ayse Se limoglu); the Dep art ment of Otolaryngology, Faculty of Medic ine, Atatilrk Uni versity, Erz urum, Tu rkey (Dr. Erol Se limoglu); and the Depart ment of Internal Medi ci ne, Facult y of Medicine, Atatlirk University, Erzururn, T urkey (Dr. Kurt).

Prevalence of Sinus Membrane Thickening and Association With Unhealthy Teeth: A Retrospective Review of 831 Consecutive Patients With 1,662 Cone-Beam Scans

“…It also has been shown that patients with diabetes may have decreased mucociliary clearance owing to alkalinized pH values of nasal secretions. 18,19 Sinus congestion triggers the disease process, which leads to obstruction of the sinus ostium and ultimately to an alteration of the microflora of the sinus cavity. If the obstruction fails to resolve, a chronic inflammatory response ensues, which affects the sinus respiratory mucosa.…”

Funktionen und Funktionsstörungen der respiratorischen Schleimhaut der Nase und der Nasennebenhöhlen

“…Parallel wiesen Diabetiker in der RMM einen erh ö hten nasalen Widerstand -und zwar gr ö ß er vor als nach Abschwellen [166] -als Ausdruck eines chronischen endonasalen Schwellungszustandes auf. Dieser wird auch durch die mukozili ä re Clearance beg ü nstigt, die in Diabetikern bei ins alkalische verschobenen pH-Werten des Nasensekretes [205] verlangsamt ist [206,207] . Der Gebrauch von Insulin und eine Erkrankungsdauer von mehr als zehn Jahren gehen mit einer weiteren Verschlechterung der mukozili ä ren Clearance einher [205] .…”

Physiology and pathophysiology of respiratory mucosa of the nose and the paranasal sinuses

“…Chronic congestion is also favoured by mucociliary clearance, the latter being reduced in diabetics [205], [206] due to alcalised pH-values of nasal secretions [207]. Insulin-dependent diabetes mellitus and diabetes lasting for more than ten years result in further deterioration of mucociliary clearance [207].…”