Nasal Nitric Oxide and the Nasal Cycle

Qian, Wei; Sabo, Reni; Ohm, Mikael; Haight, James S. J.; Fenton, R. S.

doi:10.1097/00005537-200109000-00021

Cited by 14 publications

(19 citation statements)

References 17 publications

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“…Stickstoff -Monoxid wird in der Nasenhaupth ö hle [162] , vor allem aber in den Nasennebenh ö hlen produziert [162] und soll anti-bakterielle und antivirale Eigenschaften aufweisen sowie die mukozili ä re Clearance ü ber die nasale Sekretion steuern [163,164] . Die Messung des nasalen NO [in parts per million; ppm] wird durch NO der unteren Atemwege [165] , lokale und systemische Erkrankungen und deren Therapie [166] , Kooperation [167] , Nasenzyklus [168] , Anatomie [169] und Aspekte der Messtechnik erschwert [170] . Valide Messprotokolle [171] f ü r die Messung des nasalen NO bei kooperativen Patienten [169] und Kleinkindern [172] liegen vor.…”

Section: Messung Des Exspiratorischen Nasalen Stickstoff -Monoxids (No)unclassified

Funktionen und Funktionsstörungen der respiratorischen Schleimhaut der Nase und der Nasennebenhöhlen

Beule¹

2010

Laryngo-Rhino-Otol

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In this review, anatomy and physiology of the respiratory mucosa of nose and paranasal sinuses are summarized under the aspect of its clinical significance. Basics of endonasal cleaning including mucociliary clearance and nasal reflexes, as well as defence mechanisms are explained. Physiological wound healing, aspects of endonasal topical medical therapy and typical diagnostic procedures to evaluate the respiratory functions are presented. Finally, the pathophysiologies of different subtypes of non-allergic rhinitis are outlined together with treatment recommendations.

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Section: Messung Des Exspiratorischen Nasalen Stickstoff -Monoxids (No)unclassified

Funktionen und Funktionsstörungen der respiratorischen Schleimhaut der Nase und der Nasennebenhöhlen

Beule¹

2010

Laryngo-Rhino-Otol

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“…It has anti-bacterial, as well as anti-viral properties and regulates mucociliary clearance via control of nasal secretions [163], [164]. Measurement of nasal NO [in parts per million; ppm] is influenced by lower airways [165], local and systemic diseases and their therapy [166], compliance [167], nasal cycle [168], anatomy [169] and technical aspects [170]. Valid measurement protocols have been reported [171] for compliant patients [169] and infants [172].…”

Section: Physiology Of Respiratory Mucosamentioning

confidence: 99%

Physiology and pathophysiology of respiratory mucosa of the nose and the paranasal sinuses

Beule

2010

GMS Current Topics in Otorhinolaryngology - Head and Neck Surgery; 9:Doc07; ISSN 1865-1011

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“…Nasal nitric oxide (NO) was highest in the obstructed nostril (highest airflow resistance), and reached concentrations of 1100 parts per billion (ppb) [31]. As nasal patency increased, NO concentrations dropped.…”

Section: Nasal Cyclementioning

confidence: 99%

Nasonasal reflexes, the nasal cycle, and sneeze

Baraniuk

Kim²

2007

Curr Allergy Asthma Rep

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The nasal mucosa is a complex tissue that interacts with its environment and effects local and systemic changes. Receptors in the nose receive signals from stimuli, and respond locally through afferent, nociceptive, type C neurons to elicit nasonasal reflex responses mediated via cholinergic neurons. This efferent limb leads to responses in the nose (eg, rhinorrhea, glandular hyperplasia, hypersecretion with mucosal swelling). Anticholinergic agents appear useful against this limb for symptomatic relief of a "runny nose." Chronic exposure to allergens can lead to hyperresponsiveness of the nasal mucosa. As a result, receptors upregulate specific ion channels to increase the sensitivity and potency of their reflex response. Nasal stimuli also affect distant parts of the body. Nerves in the sinus mucosa cause vasodilation; the lacrimal glands can be stimulated by nasal afferent triggers. Even the cardiopulmonary system can be affected via the trigeminal chemosensory system, where sensed irritants can lead to changes in tidal volume, respiratory rate, and blink frequency. The sneeze is an airway defense mechanism that removes irritants from the nasal epithelial surface. It is generally benign, but can lead to problems in certain circumstances. The afferent pathway involves histamine-mediated depolarization of H1 receptor-bearing type C trigeminal neurons and a complex coordination of reactions to effect a response.

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Nasal Nitric Oxide and the Nasal Cycle

Cited by 14 publications

References 17 publications

Funktionen und Funktionsstörungen der respiratorischen Schleimhaut der Nase und der Nasennebenhöhlen

Funktionen und Funktionsstörungen der respiratorischen Schleimhaut der Nase und der Nasennebenhöhlen

Physiology and pathophysiology of respiratory mucosa of the nose and the paranasal sinuses

Nasonasal reflexes, the nasal cycle, and sneeze

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