Nasal nitric oxide is increased in allergic rhinitis

Arnal, Jean‐François; Didier, A.; Rami, J.; M’Rini, Christine; Charlet, Jean-Paul; Serrano, Érica Vieira; Besombes, J. P.

doi:10.1046/j.1365-2222.1997.d01-522.x

Cited by 30 publications

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“…Arnal et al . found that both seasonal and perennial allergic rhinitis patients had significantly higher nasal nitric oxide concentrations than healthy participants 18 . The present study also found that the mean nasal nitric oxide value measured by the aspiration method was significantly higher in allergic rhinitis patients than in healthy participants.…”

Section: Discussionsupporting

confidence: 77%

Measuring nasal nitric oxide in allergic rhinitis patients

et al. 2016

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Section: Discussionsupporting

confidence: 77%

Measuring nasal nitric oxide in allergic rhinitis patients

et al. 2016

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“…The only group without COMS was the group with BPV (as defined by the diagnostic criteria). Since vertical saccadic pursuit matures in late adolescence ( 19 ), it was not considered pathological, whereas horizontal smooth pursuit functions mature by the age of 7 years ( 20 ). Smooth pursuit eye movement abnormalities (tested by electronystagmography) in young patients presenting with vestibular symptoms were reported to be more frequent in children (45%) than in adolescents (26%) ( 2 ).…”

Section: Discussionmentioning

confidence: 99%

“…Vertical saccadic pursuit was always considered as normal, and horizontal saccadic pursuit was considered as normal until the age of 7 years ( 19 , 20 ).…”

Section: Methodsmentioning

confidence: 99%

Vestibular Migraine in Children and Adolescents: Clinical Findings and Laboratory Tests

et al. 2015

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Introduction: Vestibular migraine (VM) is the most common cause of episodic vertigo in children. We summarize the clinical findings and laboratory test results in a cohort of children and adolescents with VM. We discuss the limitations of current classification criteria for dizzy children.Methods: A retrospective chart analysis was performed on 118 children with migraine related vertigo at a tertiary care center. Patients were grouped in the following categories: (1) definite vestibular migraine (dVM); (2) probable vestibular migraine (pVM); (3) suspected vestibular migraine (sVM); (4) benign paroxysmal vertigo (BPV); and (5) migraine with/without aura (oM) plus vertigo/dizziness according to the International Classification of Headache Disorders, 3rd edition (beta version).Results: The mean age of all patients was 12 ± 3 years (range 3–18 years, 70 females). 36 patients (30%) fulfilled criteria for dVM, 33 (28%) for pVM, 34 (29%) for sVM, 7 (6%) for BPV, and 8 (7%) for oM. Somatoform vertigo (SV) co-occurred in 27% of patients. Episodic syndromes were reported in 8%; the family history of migraine was positive in 65%. Mild central ocular motor signs were found in 24% (most frequently horizontal saccadic pursuit). Laboratory tests showed that about 20% had pathological function of the horizontal vestibulo-ocular reflex, and almost 50% had abnormal postural sway patterns.Conclusion: Patients with definite, probable, and suspected VM do not differ in the frequency of ocular motor, vestibular, or postural abnormalities. VM is the best explanation for their symptoms. It is essential to establish diagnostic criteria in clinical studies. In clinical practice, however, the most reasonable diagnosis should be made in order to begin treatment. Such a procedure also minimizes the fear of the parents and children, reduces the need to interrupt leisure time and school activities, and prevents the development of SV.

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“…Djupesland et al [6] reported the same result in symptomatic seasonal allergic rhinitis had a higher nNO output than normal subjects. Arnal et al [7] compared baseline nNO between allergic rhinitis patients and normal controls. They found that, whether the allergy was seasonal or perennial, and the patients had symptoms or not, subjects with allergic rhinitis had higher nNO concentrations than normal subjects; this could reflect permanent inflammation of the nasal cavity and the paranasal sinus mucosa in the allergic rhinitis patients.…”

Section: Discussionmentioning

confidence: 99%

Nasal and Exhaled Nitric Oxide in Allergic Rhinitis

Lee

Cho

Lee

et al. 2012

Clin Exp Otorhinolaryngol

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ObjectivesThe primary aim of this study was to assess whether one can use levels of nasal nitric oxide (nNO) and exhaled nitric oxide (eNO) as a means of evaluation in allergic rhinitis.MethodsWe used a chemiluminescence analyzer to measure nNO and eNO in normal controls (n=34) and allergic rhinitis patients (n=35), and compared these measurements with various parameters of clinical symptoms and laboratory data.ResultsMean nNO (389±119 ppb) in allergic rhinitis patients was significantly higher than normal controls (276±88 ppb). Without asthma, mean eNO (64.8±55.9 ppb) in allergic rhinitis patients was significantly higher than normal controls (33.0±24.0 ppb). In the persistent allergic rhinitis group, eNO concentration was significantly higher, while nNO concentration was significantly lower than the intermittent group.ConclusionWe can use nNO and eNO levels for evaluation of allergic rhinitis. However, we should consider the fact that nNO levels can be reduced, when symptoms are severe and long-lasting. Additionally, in allergic rhinitis, eNO can be elevated without asthma.

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Nasal nitric oxide is increased in allergic rhinitis

Abstract: Nasal NO concentration is increased in patients with allergic rhinitis. Interestingly, patients without symptoms on the day of the test also showed a clear-cut increase in nasal NO production, which could reflect a permanent inflammation of the sinus mucosa.

Cited by 30 publications

References 0 publications

Measuring nasal nitric oxide in allergic rhinitis patients

Measuring nasal nitric oxide in allergic rhinitis patients

Vestibular Migraine in Children and Adolescents: Clinical Findings and Laboratory Tests

Nasal and Exhaled Nitric Oxide in Allergic Rhinitis

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