2013
DOI: 10.5466/ijoms.11.261
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Nasal or Oral Immunization with GroEL Attenuates Porphyromonas gingivalis-Induced Atherosclerosis

Abstract: Periodontal disease is one of the most prevalent chronic inflammation of oral cavity, and has been reported to be associated with atherosclerosis. In this study, we assessed the potential of orally or nasally administered recombinant HSP60 from Porphyromonas gingivalis (rGroEL) for prevention of atherosclerosis accelerated by P. gingivalis. Apolipoprotein E deficient spontaneously hyperlipidemic (Apoe shl ) mice were orally or nasally immunized with GroEL and then challenged intravenously with P. gingivalis 38… Show more

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