Nasal peripheral primitive neuroectodermal tumor in a heifer: case report

Abstract

This report described the clinical signs, pathological and immunohistochemical findings associated with a peripheral primitive neuroectodermal tumor (pPNET) in the nasal cavity of a heifer. The heifer exhibited severe breathing difficulty and dysphagia, which were increased over the last thirty days. At autopsy, a large, firm, and whitish mass was found occupying the left frontal sinus and most of the left nasal cavity. Histologically, a malignant neoplastic proliferation was observed, which was composed of small cells typically arranged in nests and mantles, occasionally arranged in palisade, interspersed with moderate connective stroma. The neoplastic cells exhibited strong immunoreactivity to synaptophysin, mild, multifocal immunoreactivity to neuron-specific enolase and vimentin, with moderate, and multifocal immunoreactivity S-100 protein. These findings suggest that pPNETs should be included in the differential diagnosis of proliferative and obstructive lesions in the nasal cavity of young cattle. Key words: Neoplasm. Immunohistochemistry. PNET. ResumoEste relato descreve os sinais clínicos, achados patológicos e imuno-histoquímicos associados a um tumor neuroectodérmico primitivo periférico (pPNET) na cavidade nasal de uma novilha. A novilha apresentava dificuldade respiratória e de deglutição, com evolução de trinta dias. Na autópsia, no seio frontal esquerdo e ocupando quase toda a cavidade nasal esquerda foi observada uma grande massa firme e esbranquiçada. Histologicamente, observou-se proliferação neoplásica maligna composta de pequenas células dispostas em ninhos e manto, ocasionalmente em paliçada, intercaladas por estroma conjuntivo moderado. As células neoplásicas exibiram intensa imunomarcação para sinaptofisina, marcação leve e multifocal para enolase neurônio especifica e vimentina, com multifocal e moderada imunorreação para a proteína S-100. Esses achados sugerem que o pPNET deve ser incluído no diagnóstico diferencial de lesões proliferativas e obstrutivas na cavidade nasal de bovinos jovens. Palavras-chave: Neoplasma. Imuno-histoquímica. PNET.

Features of a rare peripheral primitive neuroectodermal tumour arising from the thoracic spine in a juvenile canine patient

“…Peripheral primitive neuroectodermal tumours have been reported uncommonly in the dog, (Abedi et al., 2013; De Cock et al., 2004; Hosokawa et al., 1998; Junginger et al., 2013) twice in bovines (Argenta et al., 2018; Berrocal et al., 2005) with a single case reported in equine,( Facemire et al., 2012) camelid (Weiss & Walz, 2009) and in a formosan serow (Hsieh et al., 2019).…”