Nasal polyps in asthma and rhinitis A review of 6,037 patients

Settipane, Guy A.; Chafee, Francis H.

doi:10.1016/0091-6749(77)90171-3

Cited by 374 publications

(231 citation statements)

References 24 publications

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“…In addition, when considering such a rare condition as Wegener's granulomatosis (UK incidence of 10.2/million/year and prevalence of 25/100 000), 12 our sample size of 199 Wegener's granulomatosis patients would, by extrapolation, be comparable to a sample group of 30 000 patients in a study of nasal polyps (prevalence of 4.2 per cent of adult population). 13 …”

Section: Discussionmentioning

confidence: 99%

Patterns of presentation and diagnosis of patients with Wegener's granulomatosis: ENT aspects

et al. 2006

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Design: a cross-sectional study.Participants: One hundred and ninety-nine patients with Wegener's granulomatosis belonging to a patient self-help group.Main outcome measures: Mode of initial presentation; diagnosis timescales and delay; rhinologic involvement; and treatment.Results: Sixty-three per cent of patients initially presented with ENT-related symptoms. Ninety-two per cent faced a delay in their diagnosis of more than one month, a pattern which has not improved over the last few decades and which compares unfavourably with North American figures. Rhinologic and otologic symptoms are a common occurrence in up to 85 and 50 per cent of Wegener's granulomatosis patients, respectively, attracting varying degrees of targeted treatment.Conclusions: As sinonasal and other ENT symptoms are so common at the presentation of Wegener's granulomatosis, it is clear that the otolaryngologist has an important role in its diagnosis and treatment. There are long delays in the diagnosis and possible under-treatment of the ENT symptoms of this condition, highlighting the need for greater awareness, particularly in the ENT community.

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Section: Discussionmentioning

confidence: 99%

Patterns of presentation and diagnosis of patients with Wegener's granulomatosis: ENT aspects

et al. 2006

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“…However, there is no convincing evidence that the correlation berween a positive allergy skin test and the presence of nasal polyps is more than coincidental (11,41), Skin testing is relevant in severe polyposis, because concomitant type I allergic reactions may contribute to the airway symptoms, independent of the nature of the correlation between polyps and allergy.…”

Section: Allergy Skin Testingmentioning

confidence: 99%

Clinical Investigation of Allergic Rhinitis and Allied Conditions

Mygind

1979

Allergy

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“…Sin embargo, estudios epidemiológicos contradicen una relación causal ya que la incidencia de poliposis en atópicos no supera 4%, siendo similar a la de la población general 10,11 . Por el contrario, en otros cuadros nasosinusales asociados a poliposis, como la rinosinusitis fúngica alérgica, se ha logrado demostrar una fuerte relación con la sensibilización a hongos mediada por inmunoglobulina E, especialmente de la familia Dermaticiae, mediada por inmunoglobulina E [12][13][14] .…”

Section: Introductionunclassified

Diferencias en la sensibilización a aeroalergenos en pacientes con poliposis nasosinusal

et al. 2009

Rev. Otorrinolaringol. Cir. Cabeza Cuello

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RESUMENIntroducción: La poliposis nasosinusal (PN) es una enfermedad inflamatoria crónica de la mucosa. Apoyado en los hallazgos clínicos, histológicos e inmunológicos, se postula a la alergia como un factor etiopatogénico, lo cual no ha sido plenamente demostrado.Objetivo: Evaluar la presencia de hipersensibilidad a aeroalergenos en pacientes con PN y compararla con pacientes normales.Material y método: Se realizó prick test a aeroalergenos a todos los pacientes utilizando 30 alergenos frecuentes en el área metropolitana de Santiago, incluyendo pólenes de árboles, malezas y pastos, ácaros, epitelio de animales y hongos habituales. Este test se amplió con el uso de tres hongos habitualmente no evaluados (Stemphyllium, Pullularia, Helminthosporium). Se utilizó la prueba de Chi cuadrado con una significancia de 0,05.Resultados: El 71% de los pacientes con PN (n =73) y el 66% del grupo control (n =44) presentaban un test cutáneo positivo, sin diferencia estadística significativa. El patrón de sensibilización a aeroalergenos fue similar, salvo para los alergenos fúngicos: los pacientes con PN estaban sensibilizados en 40% a Pullularia, 30% a Stemphyllium, y 10% a Helminthosporium. En tanto que los controles no presentaron sensibilización a estos hongos no habituales.Discusión y conclusiones: Existe una alta tasa de sensibilización a aeroalergenos en pacientes normales y con PN, lo que sugiere un probable rol de la alergia en la patogénesis de la poliposis nasal. Destaca un patrón diferente de sensibilización a alergenos fúngicos, cuya relevancia clínica debe ser evaluada a futuro.Palabras clave: Poliposis nasal, hipersensibilidad, hongos. ABSTRACTIntroduction: Nasal polyposis (NP) is a chronic inflammatory disease that leads to tissue oedema and eventually polyps. The pathogenesis of NP has not been fully understood yet, but there are clinical, histological, and immunological findings that suggest that allergy plays a role.

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Nasal polyps in asthma and rhinitis A review of 6,037 patients

Cited by 374 publications

References 24 publications

Patterns of presentation and diagnosis of patients with Wegener's granulomatosis: ENT aspects

Patterns of presentation and diagnosis of patients with Wegener's granulomatosis: ENT aspects

Clinical Investigation of Allergic Rhinitis and Allied Conditions

Diferencias en la sensibilización a aeroalergenos en pacientes con poliposis nasosinusal

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