Nasal priming with immunobiotic lactobacilli improves the adaptive immune response against influenza virus

Tonetti, Fernanda Raya; Islam, M. S.; Vizoso-Pinto, María Guadalupe; Takahashi, Hideki; Kitazawa, Haruki; Villena, Julio

doi:10.1016/j.intimp.2019.106115

Cited by 31 publications

(25 citation statements)

References 44 publications

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“…It is also thought that lactobacilli such as Lactobacillus paracasei, Lactobacillus plantarum, and Lactobacillus rhamnosus have the capacity to bind to and inactivate some viruses via adsorptive and/or trapping mechanisms (187). Other probiotic lactobacilli and even nonviable bacterium-like particles have been shown to reduce both viral attachment to host cells and viral titers, along with reducing cytokine synthesis, enhancing the antiviral alpha interferon (IFN-a) response, and inducing various other antiviral mechanisms (187)(188)(189)(190)(191)(192)(193)(194)(195). These antiviral and immunobiotic mechanisms and others have been reviewed in detail elsewhere (32,182,196).…”

Section: Probioticsmentioning

confidence: 99%

Dietary Supplements and Nutraceuticals under Investigation for COVID-19 Prevention and Treatment

2021

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Coronavirus disease 2019 (COVID-19) has caused global disruption and a significant loss of life. Existing treatments that can be repurposed as prophylactic and therapeutic agents may reduce the pandemic’s devastation. Emerging evidence of potential applications in other therapeutic contexts has led to the investigation of dietary supplements and nutraceuticals for COVID-19. Such products include vitamin C, vitamin D, omega 3 polyunsaturated fatty acids, probiotics, and zinc, all of which are currently under clinical investigation. In this review, we critically appraise the evidence surrounding dietary supplements and nutraceuticals for the prophylaxis and treatment of COVID-19. Overall, further study is required before evidence-based recommendations can be formulated, but nutritional status plays a significant role in patient outcomes, and these products may help alleviate deficiencies. For example, evidence indicates that vitamin D deficiency may be associated with a greater incidence of infection and severity of COVID-19, suggesting that vitamin D supplementation may hold prophylactic or therapeutic value. A growing number of scientific organizations are now considering recommending vitamin D supplementation to those at high risk of COVID-19. Because research in vitamin D and other nutraceuticals and supplements is preliminary, here we evaluate the extent to which these nutraceutical and dietary supplements hold potential in the COVID-19 crisis. IMPORTANCE Sales of dietary supplements and nutraceuticals have increased during the pandemic due to their perceived “immune-boosting” effects. However, little is known about the efficacy of these dietary supplements and nutraceuticals against the novel coronavirus (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) or the disease that it causes, CoV disease 2019 (COVID-19). This review provides a critical overview of the potential prophylactic and therapeutic value of various dietary supplements and nutraceuticals from the evidence available to date. These include vitamin C, vitamin D, and zinc, which are often perceived by the public as treating respiratory infections or supporting immune health. Consumers need to be aware of misinformation and false promises surrounding some supplements, which may be subject to limited regulation by authorities. However, considerably more research is required to determine whether dietary supplements and nutraceuticals exhibit prophylactic and therapeutic value against SARS-CoV-2 infection and COVID-19. This review provides perspective on which nutraceuticals and supplements are involved in biological processes that are relevant to recovery from or prevention of COVID-19.

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Section: Probioticsmentioning

confidence: 99%

Dietary Supplements and Nutraceuticals under Investigation for COVID-19 Prevention and Treatment

2021

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“…Many probiotic bacteria are members of the gut microbiota, and some are being increasingly incorporated into foods to improve gut health and wellbeing. Recently, the immunogenic potential of even non-viable probiotic cells, bacterial exopolysaccharides, and spores has also been noted [ 67 , 68 , 69 , 70 , 71 , 72 ]. Additionally, the ingestion of probiotic-rich food or supplements has been shown to influence immune functions, partly by driving changes in the metabolic activities of endogenous microbiota [ 73 ].…”

Section: Probioticsmentioning

confidence: 99%

“…In addition, many studies support the potency of intranasally administered PBs to protect mice against VRIs by stimulating local innate immune responses directly in the respiratory epithelium [ 92 , 97 , 98 , 99 , 100 , 101 ]. Some studies have also confirmed the excellent efficacy of certain heat-killed strains of Lactobacillus and Bifidobacterium to stimulate the synthesis of virus-specific immunoglobulins and cellular immune responses in respiratory secretions and serum in mice [ 67 , 68 , 69 , 70 ]. Similarly, the oral administration of mice with Bifidobacterium breve YIT4064 increased anti-influenza virus IgG antibodies in serum and protected against infection [ 102 ].…”

Section: Probioticsmentioning

confidence: 99%

Microbiota Modulating Nutritional Approaches to Countering the Effects of Viral Respiratory Infections Including SARS-CoV-2 through Promoting Metabolic and Immune Fitness with Probiotics and Plant Bioactives

et al. 2020

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Viral respiratory infections (VRIs) can spread quickly and cause enormous morbidity and mortality worldwide. These events pose serious threats to public health due to time lags in developing vaccines to activate the acquired immune system. The high variability of people’s symptomatic responses to viral infections, as illustrated in the current COVID-19 pandemic, indicates the potential to moderate the severity of morbidity from VRIs. Growing evidence supports roles for probiotic bacteria (PB) and prebiotic dietary fiber (DF) and other plant nutritional bioactives in modulating immune functions. While human studies help to understand the epidemiology and immunopathology of VRIs, the chaotic nature of viral transmissions makes it difficult to undertake mechanistic study where the pre-conditioning of the metabolic and immune system could be beneficial. However, recent experimental studies have significantly enhanced our understanding of how PB and DF, along with plant bioactives, can significantly modulate innate and acquired immunity responses to VRIs. Synbiotic combinations of PB and DF potentiate increased benefits primarily through augmenting the production of short-chain fatty acids (SCFAs) such as butyrate. These and specific plant polyphenolics help to regulate immune responses to both restrain VRIs and temper the neutrophil response that can lead to acute respiratory distress syndrome (ARDS). This review highlights the current understanding of the potential impact of targeted nutritional strategies in setting a balanced immune tone for viral clearance and reinforcing homeostasis. This knowledge may guide the development of public health tactics and the application of functional foods with PB and DF components as a nutritional approach to support countering VRI morbidity.

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“…Similarly, other studies also showed the antiviral and immunogenic action of probiotics (Lactobacillus and Bifidobacterium) against the Influenza virus, Respiratory syncytial virus, and Rotavirus (90)(91)(92)(93)(94) .…”

Section: Antiviral Effects Of Probioticsmentioning

confidence: 83%

Probiotics and Coronavirus disease 2019: think about the link

Angurana

Bansal

2020

Br J Nutr

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The pandemic of Coronavirus disease 2019 (COVID-19) is rapidly progressing, causing significant morbidity and mortality. Various antiviral drugs, anti-inflammatory drugs, and immunomodulators have been tried without substantial clinical benefits. The severe and critical cases of COVID-19 disease are characterised by gut microbiome dysbiosis, immune dysregulation, hyper-inflammation, and hypercytokinemia (cytokine storm). Therefore, the strategies which target these pathophysiological processes may be beneficial. Probiotics are one such strategy that exerts beneficial effects by manipulation of the gut microbiota, suppression of opportunistic pathogens in the gut, decrease translocation of opportunistic organisms, activate mucosal immunity, and modulation of the innate and adaptive immune response. Probiotics are the potential candidates to be tested in moderate and severe cases of COVID-19 due to several beneficial effects, including easy availability, easy to administer, and safe, and economical to use.

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Nasal priming with immunobiotic lactobacilli improves the adaptive immune response against influenza virus

Cited by 31 publications

References 44 publications

Dietary Supplements and Nutraceuticals under Investigation for COVID-19 Prevention and Treatment

Dietary Supplements and Nutraceuticals under Investigation for COVID-19 Prevention and Treatment

Microbiota Modulating Nutritional Approaches to Countering the Effects of Viral Respiratory Infections Including SARS-CoV-2 through Promoting Metabolic and Immune Fitness with Probiotics and Plant Bioactives

Probiotics and Coronavirus disease 2019: think about the link

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