NAT2 Gene Polymorphism in Bladder Cancer: A Study from North India

Abstract

Purpose: This study was conducted to examine: 1) whether the NAT2 genotypes are risk factors for bladder cancer, 2) to study possible association of tobacco usage with NAT2 genotype of these patients.Materials and Methods: This case control study was undertaken over a period of 19 months and included 101 bladder cancer patients and 110 controls. The NAT2 genotypes were identified by PCR-RFLP method in peripheral blood DNA samples. Genotypes frequencies and the association of the genotypes among patients and controls group were assessed by χ2 test and Fisher exact test.Results: The NAT2 fast acetylator genotype frequency of slow or fast acetylator genotypes was not significant in bladder cancer patients alone (OR = 1.18, 95% CI: 0.69 -2.03, p value = 0.583) or combination with tobacco users (OR = 0.84, 95% CI: 0.328 -2.125, p value = 0.813) when compared with controls.Conclusion: These data demonstrate that the NAT2 fast or slow acetylators genotype did not associated with the risk of developing bladder cancer in North Indian population when compared with controls.