2016
DOI: 10.1186/s41124-016-0012-x
|View full text |Cite|
|
Sign up to set email alerts
|

National alliance for Wilson’s disease: health policy in Costa Rica

Abstract: Wilson's disease is an inherited disorder in which defective biliary excretion of copper leads to its accumulation, particularly in the liver and brain. Mutations in the ATP7B gene on chromosome 13 cause Wilson's disease. If left untreated it will cause liver failure, neurological damage, and will be life threatening. It is considered a rare disease afflicting approximately 1 in 30,000 persons worldwide, although this rate is similar in the different countries some places show higher incidence rates. Since Cos… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2

Citation Types

1
6
0
3

Year Published

2018
2018
2024
2024

Publication Types

Select...
5

Relationship

0
5

Authors

Journals

citations
Cited by 5 publications
(10 citation statements)
references
References 25 publications
1
6
0
3
Order By: Relevance
“…Second, the number of pediatric cases identified over time was similar between Jimenez et al (2009) and our cohort. Interestingly, a higher prevalence of cases in the central province of San José is consistent with prior reports and cases described here are moderately genetically homogenous . Explanations for the higher incidence of WD in our population combined with a higher central region prevalence and a more genetically homogenous population, include consanguinity and a possible founder effect .…”
Section: Discussionsupporting
confidence: 92%
See 4 more Smart Citations
“…Second, the number of pediatric cases identified over time was similar between Jimenez et al (2009) and our cohort. Interestingly, a higher prevalence of cases in the central province of San José is consistent with prior reports and cases described here are moderately genetically homogenous . Explanations for the higher incidence of WD in our population combined with a higher central region prevalence and a more genetically homogenous population, include consanguinity and a possible founder effect .…”
Section: Discussionsupporting
confidence: 92%
“…The central province of San José was the most affected with a prevalence of 3.9:100 000, followed by the province of Puntarenas with 3.6:100 000. The difference in prevalence with previous adult population studies may be attributable to the natural history of the condition and its onset later in adulthood …”
Section: Resultsmentioning
confidence: 70%
See 3 more Smart Citations