National Athletic Trainers' Association Position Statement: Anabolic-Androgenic Steroids

Abstract

Abusers of AAS often rely on questionable information sources. Sports medicine professionals can therefore serve an important role by providing accurate, reliable information. The recommendations provide health care professionals with a current and accurate synopsis of the AAS-related research.

Biochemical Profile and Body Composition Alteration of Amateur Bodybuilders during the Pre-Contest Period

“…The high use of supratherapeutic doses of AAS by bodybuilding participants to improve body composition is well known [14,15]. The amounts of AAS used by the participants in this present study are similar to those previously reported [2,3], and are many times greater than endogenous testosterone production, which is around 2.5-11 mg/day for men and 0.25 mg/day for women [16].…”

“…The amounts of AAS used by the participants in this present study are similar to those previously reported [2,3], and are many times greater than endogenous testosterone production, which is around 2.5-11 mg/day for men and 0.25 mg/day for women [16]. Long-term abuse of AAS is associated with cardiomyopathy and atherosclerotic vascular disease caused by detrimental lipid changes [15,17]. A recent retrospective study reinforced the association between long-term abuse of AAS and premature cardiovascular disease (CVD) [7].…”

“…The potential harm associated with chronic use of AAS seems to be dose-dependent [15]. Whilst we agree that it might be difficult to become competitive in bodybuilding without drug use, it is necessary to provide strategies that could provide better results and reduce the reliance on drug abuse to help, in turn, to reduce the potential deleterious effects on the health of bodybuilders, as previously discussed [2,3,5].…”

Uso clínico de esteroides anabolizantes em idosos sarcopênicos

“…Dando maior enfoque a testosterona que é o principal andrógeno promotor de características masculinas, além da manutenção do balanço de nitrogênio e facilitador de síntese proteica 12 , a testosterona possui efeitos em diferentes tecidos, ocorrendo posteriormente à metabolização da testosterona podendo originar outros esteroides ativos, dentre eles: a dihidrotestosterona (DHT) e o estradiol, e seus efeitos parecem estar ligados à própria testosterona 12 . Segundo Fortunato 22 , a testosterona e a DHT tem o mesmo receptor de ação, o receptor de androgênio, contudo a substância que tem mais afinidade para ativação da expressão gênica sendo mais eficiente é o composto DHT.…”

“…Paradoxalmente à perda muscular, temos os esteroides anabolizantes androgênicos (EAA), uma classe terapêutica sintética, análogos da testosterona. Apresentam efeitos anabólicos -estímulo à síntese proteica e androgênicos -características masculinizantes 12,13 . A utilização de esteroides para aumentar a massa muscular iniciou-se ao redor de 1940 tanto em animais de corte como em fisiculturistas.…”