National consensus on the management of patients with hyperandrogenism (2016)

Myo-inositol is considered an additional insulin-sensitive supplement that may benefit women with polycystic ovary syndrome (PCOS). Correcting insulin resistance and lowering circulating insulin levels are key therapeutic options in the PCOS treatment, which in turn increase fertility and reduce the risk of type 2 diabetes and early cardiovascular diseases.Research objective: to determine the effectiveness of the Miofolic drug (contains myo-inositol 2000 mg, 5-methyltetrahydrofolate 200 μg, vitamin B12 2,5 μg) for the restoration of ovulatory dysfunction in women with PCOS phenotype A (ovulatory dysfunction + hyperandrogenism + polycystic ovarian structure).Materials and methods. The study included 60 women of reproductive age with PCOS phenotype A. 31 patients (group І) had normal weight, 29 patients (group ІІ) were overweight. Patients of both clinical groups received therapy with Miofolic 2 sachets for 6 months. Also, women in both groups were given recommendations for lifestyle modifications and a diet with limited carbohydrate content.Treatment efficacy was monitored after 3 and 6 months by determining body mass index, free testosterone index, 75 g glucose tolerance test, progesterone levels in the second phase of the menstrual cycle and ultrasound folliculometry.Results. In the first group, ovulatory cycles resumed after 3 months in 38.7% of patients (p < 0.05), and after 6 months in 58.06% (p < 0.01). In the second group, ovulatory cycles resumed after 3 months in 34.4% of women (p < 0.05), and after 6 months in 41.3% (p < 0.05).Conclusions. The results of this study allow us to recommend the Miofolic drug as the main method of inducing ovulation in women with PCOS with and without overweight, the period of the drug use is from 3 to 6 months. A more stable restoration of ovulatory function occurs after 6 months of therapy.

show abstract

A multidisciplinary approach in the management of patients with acne

Syusyuka

Makurina

Chornenka

et al. 2022

RHW

View full text Add to dashboard Cite

The article summarizes the data of the scientific publications about the management of patients with androgen-dependent dermatopathies, namely acne, taking into account the current view on the pathogenesis, clinical manifestations and results of the examinations of this group of women. Androgen-dependent dermatopathies are not only a medical problem but also a socio-economic one, as they lead to impaired socialization and reduced quality of life. Acne is one of the most common dermatoses. Acne is a chronic multifactorial disease of the pilosebation complex, which is clinically manifested by polymorphic rash in the form of open and closed comedones, papules, pustules, nodules. The pathogenesis of the disease is based on four main links: changes in the quantitative and qualitative composition of sebum due to hypersecretion of androgens and/or increased sensitivity of receptors to their action, impaired follicular keratinization, inflammation and changes in skin microbiome. Besides the main pathogenetic aspects, trigger factors are taken into account, such as nutrition, stress, smoking, mechanical agents. The current treatment of acne according to dermatological protocols is presented in the article, which is based on a combination of topical therapy with local retinoids and antibiotics, benzoyl peroxide, azelaic acid, in case of severe or ineffective local therapy systemic antibiotics and systemic retinoids are used. However, despite the presence of many treatment regimens for dermatosis, it is often not possible to achieve a lasting effect of treatment, and the adherence of patients to follow the doctor’s recommendations decreases. Given that the leading role in the pathogenesis of acne is due to hyperandrogenic effects on the skin, as well as the fact that the disease reduces the quality of life and self-esteem in patients, it is necessary to involve a wider range of specialists, such as dermatologists, gynecologists, endocrinologists and psychotherapists for successful treatment and prevention of persistent aesthetic skin defects.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

National consensus on the management of patients with hyperandrogenism (2016)

Cited by 7 publications

References 55 publications

Problems of delayed birth: the features of fertility in older reproductive age women and their correction methods

Problems of delayed birth: the features of fertility in older reproductive age women and their correction methods

Features of the ovulatory function restoration in women

A multidisciplinary approach in the management of patients with acne

Contact Info

Product

Resources

About