“…Some of the most common general difficulties are: threats to confidentiality and privacy (Khoumbati et al, 2010) of ICT infrastructure, legal and administrative barriers, costs of system implementation and maintenance (Haigh, 2004;Cripps et al, 2011), the cost of updating (Haux, 2006), costly modern systems (Ammenwerth et al, 2003), sufficient investment, delays in implementation and providing electronic devices and software (Lucas, 2008). Also the most important challenges in specific aspects are: poor design and implementation, lack of system interoperability with electronic health records and other IT tools (Lawler et al, 2011), system compatibility with personal tasks (Viitanen et al, 2011), decrease in face to face communication between doctor and patient (Lluch, 2011), omission of human relationship and the negative effects of technology on relationships between individuals and social processes (Gustafsson et al, 2003), designing of E-Health services content (Hardiker et al, 2011), failure to meet targets (Lucas, 2008), problem in responsibility (Rigby, 1999), virtual information control (While et al, 2011), ill-functioning of system that leads to medical errors and negative effects on care outcomes, patients and personnel (Ammenwerth et al, 2003;Nykanen et al, 2011), mistakes in documentation (Lawler et al, 2011) e.g. data manipulation and re-writing, misrepresentation, and violation of patients' legal rights.…”