ObjectivesTo investigate the concurrent changes in part-time work and sickness absence (SA) in healthcare. Another aim was to investigate the role of age and sex on different concurrent trajectory groups.DesignProspective cohort study.SettingPublic hospital districts (n=10) and cities (n=11) in Finland.ParticipantsPayroll-based objective working hour data of the healthcare sector in Finland for 28 969 employees in 2008–2019 were used. The final sample included those working shifts with 3 consecutive years of data and without baseline (≥14 days) SA.Primary outcomesPart-time work (yes or no) and months of SA.MeasuresGroup-based trajectory modelling to identify concurrent changes in part-time work, and months of SA while controlling the time-variant amount of night work and multinomial regression models for relative risk (RR) with 95% CIs were used.ResultsFour-group trajectory model was the best solution: group 1 (61.2%) with full-time work and no SA, group 2 (16.9%) with slowly increasing probability of part-time work and low but mildly increasing SA, group 3 (17.6%) with increasing part-time work and no SA, and group 4 (4.3%) with fluctuating, increasing part-time work and highest and increasing levels of SA. Men had a lower (RR 0.49–0.75) and older age groups had a higher likelihood (RRs 1.32–3.79) of belonging to trajectory groups 2–4.ConclusionsMost of the sample were in the trajectory group with full-time work and no SA. The probability of part-time work increased over time, linked with concurrent low increase or no SA. A minor group of employees had both an increased probability of part-time work and SA. Part-time work and other solutions might merit attention to promote sustainable working life among healthcare employees.