Nationwide German Multicenter Study on the Prevalence of Antibiotic Resistance in Streptococcal Blood Isolates from Neutropenic Patients and Comparative In Vitro Activities of Quinupristin-Dalfopristin and Eight Other Antimicrobials

Reinert, Ralf René; Eiff, Christof von; Kresken, Michael; Brauers, J.; Häfner, D.; Al‐Lahham, Adnan; Schorn, H.; Lütticken, Rudolf; Peters, Georg

doi:10.1128/jcm.39.5.1928-1931.2001

Cited by 17 publications

(8 citation statements)

References 24 publications

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“…The percentage of strains resistant to penicillin is seen to differ from region to region. Lower resistance rates were reported in Germany [ 19 ] compared with the rates observed in our study or that observed in the study from Spain [ 15 ]. Such geological variance has also been noted in a surveillance program that covered multiple hospitals from the United States, Canada, and Latin America [ 12 ].…”

Section: Discussioncontrasting

confidence: 87%

Species-Specific Difference in Antimicrobial Susceptibility Among Viridans Group Streptococci

2015

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BackgroundViridans group streptococci (VGS) are both commensal microbes and potential pathogens. Increasing resistance to penicillin in VGS is an ongoing issue in the clinical environment. We investigated the difference in susceptibility and resistance to penicillin among various VGS species.MethodsIn total 1,448 VGS isolated from various clinical specimens were analyzed over a two-yr period. Identification and antimicrobial susceptibility test was performed by the automated VITEK 2 system (bioMerieux, France) or the MicroScan MICroSTREP system (Siemens, Germany).ResultsAmong the 1,448 isolates, 412 were isolated from blood (28.4%). Streptococcus mitis group was the most frequently isolated (589 isolates, 40.7%), followed by the S. anginosus group (290 isolates, 20.0%), S. sanguinis group (179 isolates, 12.4%) and S. salivarius group (57 isolates, 3.9%). In total, 314 isolates could not be identified up to the species level. The overall non-susceptibility to penicillin was observed to be 40.0% (resistant, 11.2% and intermediately resistant, 28.8%) with uneven distribution among groups; 40.2% in S. sanguinis group (resistant, 5.0% and intermediately resistant, 35.2%), 60.3% in S. mitis group (resistant, 20.9% and intermediately resistant, 39.4%), 78.9% in S. salivarius group (resistant, 8.8% and intermediately resistant, 70.1%), and 6.2% in S. anginosus group (resistant, 1.7% and intermediately resistant, 4.5%).ConclusionsAntimicrobial resistance patterns towards penicillin show differences among various VGS; this should be considered while devising an effective antimicrobial treatment against VGS.

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Section: Discussioncontrasting

confidence: 87%

Species-Specific Difference in Antimicrobial Susceptibility Among Viridans Group Streptococci

2015

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“…9 Indeed, in a recent study in Germany, S. oralis and S. pneumoniae were found to be the most frequent causes of bacteremia due to viridans streptococci in neutropenic patients. 12 The ability to treat such infections is hampered by the growing resistance of the organism to a number of antibiotics, including erythromycin, tetracycline, and penicillin. 12,15 In the present study, we found that the proportion of mercury-resistant S. oralis strains isolated after placement of the mercury amalgam fillings that were resistant to erythromycin and tetracycline was 21% and 7%, respectively.…”

Section: Discussionmentioning

confidence: 99%

Effect of Restoration of Children's Teeth with Mercury Amalgam on the Prevalence of Mercury- and Antibiotic-Resistant Oral Bacteria

Pike¹,

Lucas²,

Petrie³

et al. 2003

Microbial Drug Resistance

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The purpose of this study was to determine whether placement of mercury amalgam restorations in children's teeth induces an increase in oral bacteria resistant to mercury, penicillin, ampicillin, erythromycin, or tetracycline. Dental plaque and saliva samples from 16 children without mercury amalgam restorations were screened for bacteria resistant to mercury or to one of the antibiotics prior to, and 1 month after, placement of the amalgam restoration. Following amalgam placement, there was no significant increase in the number of children harboring bacteria resistant to mercury, penicillin, ampicillin, erythromycin, or tetracycline; neither was there an increase in the proportions of such organisms. This study has shown that the presence of mercury restorations in children's teeth has little effect on the prevalence of mercury- or antibiotic-resistant oral bacteria.

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“…Almost all streptococci studied have been found to be susceptible [14,22]. Occasionally, nonsusceptible isolates are encountered [1,2,[22][23][24][25]. In a worldwide survey for the period of 1997-2000, isolates of viridans streptococci recovered in Asia showed the lowest rate of susceptibility, at 96% [22].…”

mentioning

confidence: 99%

Quinupristin‐Dalfopristin and Linezolid: Evidence and Opinion

2003

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Quinupristin-dalfopristin and linezolid demonstrate in vitro activity against a wide range of gram-positive bacteria, including many isolates resistant to earlier antimicrobials. Quinupristin-dalfopristin is inactive against Enterococcus faecalis but has been effective for treatment of infections due to vancomycin-resistant Enterococcus faecium associated with bacteremia. In comparative trials, linezolid proved to be equivalent to comparator agents, resulting in its approval for several clinical indications. The almost-complete bioavailability of linezolid permits oral administration. Each agent can cause adverse effects that may limit use in individual patients. Resistance to these drugs has been encountered infrequently among vancomycin-resistant E. faecium. Resistance to quinupristin-dalfopristin is rare among staphylococci in the United States, and resistance to linezolid is very rare. Whether there is any benefit to use of these agents in combination regimens, and whether there are circumstances in which they might be alternatives to cell-wall active antibiotics for treatment of bone or endovascular infections, are questions that deserve further study.

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Nationwide German Multicenter Study on the Prevalence of Antibiotic Resistance in Streptococcal Blood Isolates from Neutropenic Patients and Comparative In Vitro Activities of Quinupristin-Dalfopristin and Eight Other Antimicrobials

Cited by 17 publications

References 24 publications

Species-Specific Difference in Antimicrobial Susceptibility Among Viridans Group Streptococci

Species-Specific Difference in Antimicrobial Susceptibility Among Viridans Group Streptococci

Effect of Restoration of Children's Teeth with Mercury Amalgam on the Prevalence of Mercury- and Antibiotic-Resistant Oral Bacteria

Quinupristin‐Dalfopristin and Linezolid: Evidence and Opinion

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