Native immunity and oxidative traits of growing rabbits

Abstract

AbstrAct:The evaluation of animal welfare through innate immunity (Serum Bactericidal Activity -SBA, Hemolytic Complement Assay -HCA, lysozyme) and the antioxidant status of the body (Reactive Oxygen Substances -ROS and Antioxidant Power of plasma, AP) offers a reliable prognostic and diagnostic tool. The aim of the present study was to investigate trends and correlations between some traits of innate immunity and the oxidative status of fattening rabbits at different ages. Blood samples from 120 New Zealand White fattening rabbits at 45, 55, 65, and 75 d of age were collected and analyzed. The results showed that SBA did not have a normal distribution because of numerous 0 values. Data distribution was normal when only SBA > 0 values were considered. Lysozyme (mean value 27.19 μg/mL) and HCA (mean value 50.84 CH 50% ) had stable trends at different ages and showed a tendency that was comparable to that obtained in other animal species. On the contrary, SBA (mean value 42.15%) showed an unexpected positive correlation with lysozyme (P<0.001) and a negative correlation with HCA (P<0.001). Oxygen free-radicals are involved in the pathogenesis of several diseases and oxidative stress alters immune competence. In this experiment, ROS and AP showed mean values of 0.60 mmol H 2 O 2 and 421.67 μmol HClO, respectively. In this context positive correlation coefficients between oxidative status traits and immune traits (P<0.001) were found, although at a very low level; and surprisingly, only ROS and SBA did not show any significant correlation. In this study it emerged that, even in the absence of evident pathologies, the immune and oxidative traits of fattening rabbits could be affected by environmental stress (weaning, cage, neighbors).

Resistance of the rabbit dams’ organism at drinking supplemuted by chlorella suspension, sodium sulfate, chromium chloride and citrate

“…It is able, on the one hand, to break down the relationship between N-acetylmuramic acid and N-acetylglucosamine as an enzyme, and on the other hand, lysozyme is able to mobilize other nonspecific factors of organism's defense. It's present in azurophilic granules and specific neutrophils grains and also monocytes and macrophages grains [17]. Similarly, serum bactericidal activity reacted to the action of above listed fodder the experimental groups in comparison to control.…”

IMPACT OF DIETARY SUPPLEMENTATION WITH MORINGA (Moringa oleifera) ON PRODUCTIVE PERFORMANCE, PHYSIOLOGICAL RESPONSE AND IMMUNITY OF GROWING RABBITS

“…Sudha et al, (2010) showed that methanol extract of moringa leaves given orally to mice at doses of 250 and 750 mg/kg stimulated both cellular and humoral immune responses. Moscati et al, (2008) reported that lysozyme at level of 27.19 μg / ml is a strong antibacterial enzyme (against Gram positive) and has a synergic action with immune humeral response, and factors of the serum complement. Moscati, et al, (2008) recorded that lysozyme value of 27.19 μg/ml as an innate immunity indicator was higher than those reported by Carroll and Martinez, (1979) in healthy rabbits (0.85 μg/ml).…”

Effect of pasture availability and genotype on welfare, immune function, performance and meat characteristics of growing rabbits

“…Serum lysozyme is a strong antibacterial enzyme (against Gram⁺) that has a synergic action with immune humoral response and the serum complement (Carroll and Martínez, 1979;Moscati et al, 2008) and is related with macrophage function indicating an inflammation state.…”