Native T1 Mapping in Differentiation of Normal Myocardium From Diffuse Disease in Hypertrophic and Dilated Cardiomyopathy

Püntmann, Valentina O.; Voigt, Tobias; Chen, Zhong; Mayr, Manuel; Karim, Rashed; Rhode, Kawal; Pastor, Ana; Carr‐White, Gerald; Razavi, Reza; Schaeffter, Tobias; Nagel, Eike

doi:10.1016/j.jcmg.2012.08.019

Cited by 411 publications

(307 citation statements)

References 32 publications

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“…In a 3-Tesla CMR study by Dass et al native T1 values in DCM were elevated compared to healthy volunteers and the authors concluded that native T1 mapping detects underlying disease processes beyond those assessed by LGE imaging in relatively low-risk individuals [4]. A study by Puntman et al showed similar results [53]. Also abnormally elevated ECV values were shown in patients with presence of non-ischemic DCM [54].…”

Section: Dilated Cardiomyopathy (Dcm)mentioning

confidence: 94%

T1, T2 Mapping and Extracellular Volume Fraction (ECV): Application, Value and Further Perspectives in Myocardial Inflammation and Cardiomyopathies

Roller¹,

Harth²,

Schneider³

et al. 2015

Fortschr Röntgenstr

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!Cardiac magnetic resonance imaging (CMRI) is a versatile diagnostic tool. One of its main advantages is the possibility of tissue characterization. T1-weighted images for scar and T2-weighted images for edema visualization are key methods for tissue characterization. Otherwise these sequences are strongly limited for the detection of diffuse myocardial pathologies. Recently, rapid technical innovations have generated new techniques. T1, T2 mapping and evaluation of the extracellular volume fraction (ECV) allow quantification of diffuse myocardial pathologies and showed great potential in the visualization of fibrosis, edema, amyloid, iron overload and lipid. In the future these techniques might enable the detection of early cardiac involvement, even act as a prognosticator. Moreover, therapy monitoring and follow-up might be possible due to versatile parameter quantification with these new techniques. Key points:▶ CMR allows for tissue characterization via T1-and T2-weighted sequences.▶ In cases of diffuse, global myocardial pathologies, correct image interpretation with traditional CMR sequences might be difficult.▶ T1, T2 mapping and ECV can quantify diffuse, global myocardial pathologies.

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Section: Dilated Cardiomyopathy (Dcm)mentioning

confidence: 94%

T1, T2 Mapping and Extracellular Volume Fraction (ECV): Application, Value and Further Perspectives in Myocardial Inflammation and Cardiomyopathies

Roller¹,

Harth²,

Schneider³

et al. 2015

Fortschr Röntgenstr

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“…Puntmann et al [30] reported higher precontrast T1 values for hypertrophic and nonischemic dilated cardiomyopathies at 3 T compared with controls (Hypertrophic 1.254 ± 43 ms, and nonischemic dilated cardiomyopathy 1.239 ± 57 ms vs. healthy 1.070 ± 55 ms). Also, the postcontrast T1 values (10 mins) at 3 T were shorter in hypertrophic and dilated cardiomyopathies compared with healthy (hypertrophic: 307 ± 47 ms, dilated cardiomyopathies: 296 ± 43 ms vs. controls: 402 ± 58 ms) [30].…”

Section: Mri Field Strengthmentioning

confidence: 99%

Cardiac Magnetic Resonance T1 Mapping in Cardiomyopathies

Hamilton-Craig¹,

Strudwick²,

Galloway³

2017

Cardiomyopathies - Types and Treatments

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Cardiac magnetic resonance (CMR) imaging has been widely used to assess myocardial perfusion and scar and is the noninvasive reference standard for identification of focal myocardial fibrosis. However, the late gadolinium enhancement (LGE) technique is limited in its accuracy for absolute quantification and assessment of diffuse myocardial fibrosis by technical and pathophysiological features. CMR relaxometry, incorporating T1 mapping, has emerged as an accurate, reproducible, highly sensitive, and quantitative technique for the assessment of diffuse myocardial fibrosis in a number of disease states. We comprehensively review the physics behind CMR relaxometry, the evidence base, and the clinical applications of this emerging technique.

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“…ECV provides quantitative estimates of diffuse myocardial fibrosis in patients with HCM, validated by surgical myocardial biopsy [46,50,51]. (Figure 3) Comparing HCM patients with healthy subjects, all T1-mapping parameters (native T1, post-contrast and ECV) prove highly accurate; however, the native T1 value shows the greatest discriminatory power, with a diagnostic accuracy of 98% [52].…”

Section: T1 Mapping In Hcmmentioning

confidence: 99%

Assessment of Myocardial Fibrosis in Hypertrophic Cardiomyopathy by Cardiac Magnetic Resonance: Modalities and Clinical Applications

Contaldi

2016

ICFJ

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Hypertrophic cardiomyopathy (HCM) is a primary myocardial disease caused by mutations in sarcomeric contractile proteins, characterized by cardiomyocytes disarray, interstitial fibrosis, increased arteriolar wall thickness and scarring.Fibrosis could represent a substrate for the generation of malignant ventricular tachyarrhythmias, which represent the current pathway for sudden cardiac death and is responsible for passive diastolic dysfunction, that is the leading cause of dyspnea.The aim of this review is to depict the increasingly role of cardiac magnetic resonance (CMR) for assessment of myocardial fibrosis in HCM. This article will briefly review the current status of the novel CMR techniques (the Late Gadolinium Enhancement and the emerging T1 mapping) for identification, characterization and quantization of myocardial fibrosis in HCM.In addition, this review will discuss the most recent acquisition techniques, the new parameters and their possible clinical utility in diagnosis, therapeutic management and prognosis in HCM.

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Native T1 Mapping in Differentiation of Normal Myocardium From Diffuse Disease in Hypertrophic and Dilated Cardiomyopathy

Abstract: This study demonstrates that native and post-contrast T1 values provide indexes with high diagnostic accuracy for the discrimination of normal and diffusely diseased myocardium.

Cited by 411 publications

References 32 publications

T1, T2 Mapping and Extracellular Volume Fraction (ECV): Application, Value and Further Perspectives in Myocardial Inflammation and Cardiomyopathies

T1, T2 Mapping and Extracellular Volume Fraction (ECV): Application, Value and Further Perspectives in Myocardial Inflammation and Cardiomyopathies

Cardiac Magnetic Resonance T1 Mapping in Cardiomyopathies

Assessment of Myocardial Fibrosis in Hypertrophic Cardiomyopathy by Cardiac Magnetic Resonance: Modalities and Clinical Applications

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