Native T1 Mapping in Transthyretin Amyloidosis

Fontana, Marianna; Banypersad, Sanjay M.; Treibel, Thomas A.; Maestrini, Viviana; Sado, Daniel; White, Steven K; Pica, Silvia; Castelletti, Silvia; Piechnik, Stefan K.; Robson, Matthew D; Gilbertson, Janet A.; Rowczenio, Dorota; Hutt, David F.; Lachmann, HJ; Wechalekar, Ashutosh; Whelan, Carol; Gillmore, Julian D.; Hawkins, Philip N.; Moon, James

doi:10.1016/j.jcmg.2013.10.008

Cited by 368 publications

(257 citation statements)

References 21 publications

Supporting

Mentioning

245

Contrasting

Unclassified

Order By: Relevance

“…In this context native T1 mapping offers great potential for accurate identification of amyloidosis [6]. Compared to other diseases, the native T1 values are much higher in amyloidosis and the ECV values are also clearly elevated as further studies showed [6,63]. Therefore, T1 mapping might be applicable as an early disease marker due to the detection of global myocardial changes.…”

Section: Amyloidosismentioning

confidence: 99%

“…Therefore, T1 mapping might be applicable as an early disease marker due to the detection of global myocardial changes. A recent study by Fontana et al showed that native T1 mapping even offers potential for the differentiation of AL amyloidosis and transthyretin amyloidosis [63]. Due to the absence of edema in amyloidosis, no T2 alterations are detected.…”

Section: Amyloidosismentioning

confidence: 99%

See 1 more Smart Citation

T1, T2 Mapping and Extracellular Volume Fraction (ECV): Application, Value and Further Perspectives in Myocardial Inflammation and Cardiomyopathies

Roller¹,

Harth²,

Schneider³

et al. 2015

Fortschr Röntgenstr

View full text Add to dashboard Cite

!Cardiac magnetic resonance imaging (CMRI) is a versatile diagnostic tool. One of its main advantages is the possibility of tissue characterization. T1-weighted images for scar and T2-weighted images for edema visualization are key methods for tissue characterization. Otherwise these sequences are strongly limited for the detection of diffuse myocardial pathologies. Recently, rapid technical innovations have generated new techniques. T1, T2 mapping and evaluation of the extracellular volume fraction (ECV) allow quantification of diffuse myocardial pathologies and showed great potential in the visualization of fibrosis, edema, amyloid, iron overload and lipid. In the future these techniques might enable the detection of early cardiac involvement, even act as a prognosticator. Moreover, therapy monitoring and follow-up might be possible due to versatile parameter quantification with these new techniques. Key points:▶ CMR allows for tissue characterization via T1-and T2-weighted sequences.▶ In cases of diffuse, global myocardial pathologies, correct image interpretation with traditional CMR sequences might be difficult.▶ T1, T2 mapping and ECV can quantify diffuse, global myocardial pathologies.

show abstract

Section: Amyloidosismentioning

confidence: 99%

Section: Amyloidosismentioning

confidence: 99%

T1, T2 Mapping and Extracellular Volume Fraction (ECV): Application, Value and Further Perspectives in Myocardial Inflammation and Cardiomyopathies

Roller¹,

Harth²,

Schneider³

et al. 2015

Fortschr Röntgenstr

View full text Add to dashboard Cite

show abstract

“…On T1 mapping, if the myocardium crosses the null point at a T1 time point prior to the blood pool, it indicates the presence of diffuse global hyperenhancement and is characteristic of cardiac amyloidosis. Native (pre-contrast) T1 times in patients with cardiac amyloidosis were significantly prolonged compared to hypertrophic cardiomyopathy and healthy subjects 60 . Native T1 mapping techniques may be particularly helpful in patients with renal dysfunction (due to risk of gadolinium toxicity).…”

Section: Magnetic Resonancementioning

confidence: 91%

Amyloid cardiomyopathy

Karafiátová¹,

Pika²

2017

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

View full text Add to dashboard Cite

“…Although native T1 and ECV data are helpful for early detection of cardiac involvement in systemic amyloidosis or suspected cardiac amyloidosis [45][46][47], the prognostic value of T1 mapping is rarely reported. T1 mapping can also provide information about disease severity and serve as a monitoring tool for chemotherapy in amyloid light-chain amyloidosis [48].…”

Section: Cardiac Amyloidosis and Sarcoidosismentioning

confidence: 99%

The Prognostic Role of T1 Mapping Sequences: Can T1 Mapping Parameters Have a Role in Risk Stratification?

Choi

Park

Kim

2017

Cardiovasc Imaging Asia

View full text Add to dashboard Cite

Cardiovascular disease risk stratification and prognostication are very important for treatment planning. In addition, for a growing number of patients with overt symptomatic heart failure or asymptomatic but have structural heart disease, accurate risk stratification is essential. Conventional clinical cardiovascular risk factors, several biomarkers and echo-Doppler indexes are generally used to satisfy this need. However, non-invasive approaches to direct structural and tissue characterization of the myocardium have not produced satisfactory results. The recent development of the late gadolinium enhancement (LGE) imaging allows fibrosis or myocardial inflammation to be visualized. A growing body of evidence for LGEbased prognostication has been reported. However, not all patients with heart failure or at risk for it have been assessed with LGE. Moreover, the degree of diffuse fibrosis or inflammation cannot be easily quantified with LGE techniques. Recently, introduced T1 mapping-based quantification can provide the volume of extracellular space suggestive of the degree of diffuse tissue fibrosis or inflammation. Even without gadolinium contrast, native T1 values can provide quantitative information on myocardial tissue status. Here, we review current evidence for T1 mapping-based risk stratification and prognostication for various cardiac diseases that can lead to heart failure or lethal arrhythmic events.

show abstract

Native T1 Mapping in Transthyretin Amyloidosis

Abstract: Native myocardial T1 mapping detects cardiac ATTR amyloid with similar diagnostic performance and disease tracking to AL amyloid, but with lower maximal T1 elevation, and appears to be an early disease marker.

Cited by 368 publications

References 21 publications

T1, T2 Mapping and Extracellular Volume Fraction (ECV): Application, Value and Further Perspectives in Myocardial Inflammation and Cardiomyopathies

T1, T2 Mapping and Extracellular Volume Fraction (ECV): Application, Value and Further Perspectives in Myocardial Inflammation and Cardiomyopathies

Amyloid cardiomyopathy

The Prognostic Role of T1 Mapping Sequences: Can T1 Mapping Parameters Have a Role in Risk Stratification?

Contact Info

Product

Resources

About