Nattospes as Effective and Safe Functional Supplements in Management of Stroke

Abstract

Stroke remains a major cause of human disability worldwide. Interventions and rehabilitation at the poststroke stage are critical for recovery. A single-blinded randomized controlled trial was conducted on 61 patients diagnosed with subacute stage of ischemic stroke. Ingestion of Nattospecs was tested as an adjuvant to support rehabilitation when combined with standard of care (SOC) treatment (electroacupuncture and Naatrapyl) (Trial group) and compared to SOC treatment alone (Control group). After 60 days, results showed that both Trial and Control groups achieved significant improvements in physical activities, blood pressure control, serum lipid panels, and quality of life. Nattospes as a food supplement has good supportive effects on treatment and rehabilitation after ischemic stroke by showing statistically significant improvement of stroke-related symptom in scores from modified Rankin, Orgogozo, and Barthel scales. In addition, Nattospes showed a good safety profile, with no adverse effects reported in both clinical and paraclinical parameters. This study indicated that Nattospes as nutraceutical supplement can be applied safely and effectively in the management of subacute stage ischemic stroke. The findings of the study may also encourage further extensive clinical trials to fully explore the prospect of Nattospes as a nutraceutical adjunct in the management of cardiovascular disease.

Effective management of atherosclerosis progress and hyperlipidemia with nattokinase: A clinical study with 1,062 participants

“…In clinical studies completed to date, the daily dose between studies can vary up to 10 times. Daily doses range from as low as 1,200 FU (25); 2,000 FU (18,(25)(26)(27)(28)(29)(30); 3,000 FU (31); 4,000 FU (17) to higher doses, 6,000 FU (5), 7,000 FU (19) and 13,000 FU (32). We believe that the reason for the wide discrepancies and inconsistencies in the doses is that there have been no authoritative data on the effective dose (ED) or effective concentration (EC) of NK, the minimum effective dose (MED) and the maximum effective dose or the maximum tolerated dose (MTD).…”

Nattokinase as a functional food ingredient: therapeutic applications and mechanisms in age-related diseases

“…Correspondingly, a clinic trial on patients diagnosed with subacute stage of ischemic stroke reported that oral administration of four NK capsules (300 FU/capsule) daily for 60 days showed supportive effects on treatment and rehabilitation after ischemic stroke by showing statistically significant improvement of stroke-related symptom [60], encouraging further extensive clinical trials to fully explore the prospect of NK as an alternative to tPA in ischemic stroke. Mechanistically, it is suggested that NK protects brain against ischemia by elevating cAMP level to inhibit platelets, activating JAK1/STAT1 pathway to suppress apoptosis, promoting nitric oxide (NO) level to relax vascular smooth muscle, and increasing fibrinolytic activity to protect endothelial cells.…”

The Interplay of Sports and Nutrition in Neurological Health and Recovery

“…In these cases, it is essential that the food provided is based on texture-modified foods, with a high caloric density, as well as hyperproteic foods [19]. When this is not possible, supportive feeding by nasogastric tube can be used [20]. Additionally, in these patients we found a microbial profile similar to healthy controls in terms of α-abundance and structure; it was found that patients with LCA presented more producers of short-chain fatty acids, including Odoribacter, Akkermansia, Ruminococcaceae_UCG_005 and Victivallis.…”