Natural Bioactive Molecules

Ghosh, Jyotirmoy; Sil, Parames C.

doi:10.1016/b978-0-444-63473-3.00011-3

Cited by 3 publications

(2 citation statements)

References 145 publications

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“…Due to their ability to rapidly enter cells, some flavonoids can reach the nucleus, and enhance the interactions between the cytosolic and nuclear molecules in cultured neurons. For example, a concentration between 25 and 50 µM of quercetin can help the neurons survive the oxidative stress caused by cytotoxic substances such as glutamate, amyloid peptide, and H 2 O 2 [2].…”

Section: Polyphenols and Flavonoids Contentmentioning

confidence: 99%

“…Many microbial metabolites are bioactive molecules with antibacterial, anticancer, and antiviral activity [1] and several other therapeutic effects on the organism pathophysiology. These natural compounds demonstrated their superiority compared to synthetic compounds because they have the potential to be safe and nontoxic [2]. Usually, valuable metabolites are obtained from a single strain or a mixture of starter culture throughout controlled biotechnological conditions [3].…”

Section: Introductionmentioning

confidence: 99%

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Tailoring the Optimized Fermentation Conditions of SCOBY-Based Membranes and Milk Kefir Grains to Promote Various Functional Properties

Pihurov

Păcularu-Burada

Cotârleț

et al. 2022

Foods

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Kombucha culture (named SCOBY-Symbiotic Culture of Bacteria and Yeasts) and milk kefir grains represent multiple consortia of wild microorganisms that include lactic acid bacteria, acetic acid bacteria and yeasts with valuable functional properties. Their fermentative potential provides a wide range of derivate metabiotics (prebiotics, probiotics, postbiotics and paraprobiotics) with valuable in vitro and in vivo benefits. This study targeted the evaluation of the functionality of a co-culture of SCOBY-based membranes and milk kefir grains, used as freeze-dried starter cultures, for the fermentation of a newly formulated medium based on black tea infusion, supplemented with bovine colostrum and sugar, in order to produce bioactive compounds with functional properties. The design and optimization of the biotechnological process were achieved by using the Plackett–Burman experimental design (six factorial points, three center points) and the response surface methodology and central composite design (three factorial points, six axial points and two center points in axial) tools. The statistical analysis and the mathematical modelling of the responses such as the pH, titratable acidity, antioxidant activity and antimicrobial activity (against Bacillus subtilis, Escherichia coli, Staphylococcus aureus and Aspergillus niger) were investigated. Further, the composition of organic acids, polyphenols and flavonoids of the fermented product obtained under the optimized fermentation conditions was also analyzed. The fermentation of the medium containing 6.27% (w/v) bovine colostrum powder, 1.64% (w/v) black tea, 7.5% (w/w) sugar, pH 6.7, with an inoculum based of 0.36% (w/v) milk kefir grains powder and 0.5% (w/v) SCOBY-based membrane (both as freeze-dried culture), at 30 °C, for 5 days, in an aerobic stationary system, revealed an antifungal activity between 80 and 100% against Aspergillus niger, an antibacterial activity of 8–22 mm against Escherichia coli and Bacillus spp. And a titratable acidity of 445 °Th. The chemical composition of the obtained product had a positive impact on the functional properties of the fermented products in terms of the antimicrobial and antioxidant properties.

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Section: Polyphenols and Flavonoids Contentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Tailoring the Optimized Fermentation Conditions of SCOBY-Based Membranes and Milk Kefir Grains to Promote Various Functional Properties

Pihurov

Păcularu-Burada

Cotârleț

et al. 2022

Foods

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Preparation of functionalized cotton fabrics by means of melatonin loaded β-cyclodextrin nanosponges

Mihailiasa

Caldera

et al. 2016

Carbohydrate Polymers

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Angelica sylvestris and Delphinium staphisagria Extracts Induces Antiproliferation through Caspase-mediated Apoptosis on Human Cancer Cells

Akgün

Akgun

Sahin

et al. 2022

Braz. arch. biol. technol.

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Angelica sylvestris and Delphinium staphisagria are medicinal and aromatic herbs with a long history in medicine and food industry. In this study, we have investigated anti-cancer activity of Angelica sylvestris and Delphinium staphisagria extracts on various cell lines of lung (A549), breast (MCF-7), colon (HT-29), and cervix (HeLa) origin. Also, cytotoxicity was tested on human healthy bronchial epithelial (BEAS-2B) cells. In vitro experiments showed that plant extracts suppressed cell growth and proliferation at low concentrations by reducing cell viability on cancer cells in a time and concentration-dependent manner. It was observed that Angelica sylvestris was more effective in HT-29 and HeLa cells and Delphinium staphisagria in A549 and MCF-7 cells by suppressing cell proliferation and increasing cell death. Cell death mode (apoptosis/necrosis) was investigated via fluorescent imaging, caspase-cleaved cytokeratin 18, activated caspase-3, and cleaved-PARP (poly (ADP-ribose) polymerase). In order to evaluate the cell death HIGHLIGHTS• Anticancer activities of ASE and DSE extracts were investigated.• Angelica sylvestris have anticancer potential on HT-29 and HeLa cells.• Delphinium staphisagria have anticancer potential on A549 and MCF-7 cells.• ASE and DSE extracts induce apoptosis on cancer cells.

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Natural Bioactive Molecules

Cited by 3 publications

References 145 publications

Tailoring the Optimized Fermentation Conditions of SCOBY-Based Membranes and Milk Kefir Grains to Promote Various Functional Properties

Tailoring the Optimized Fermentation Conditions of SCOBY-Based Membranes and Milk Kefir Grains to Promote Various Functional Properties

Preparation of functionalized cotton fabrics by means of melatonin loaded β-cyclodextrin nanosponges

Angelica sylvestris and Delphinium staphisagria Extracts Induces Antiproliferation through Caspase-mediated Apoptosis on Human Cancer Cells

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