Natural Cationic Polymers for Advanced Gene and Drug Delivery

Abstract

Gene and drug delivery is becoming more and more important in the treatment of complicated human diseases. Proper gene/drug delivery systems can effectively enhance therapeutic efficiency and minimize various side-effects. To date, a variety of delivery systems have been developed. Different from synthetic materials, natural polymers are abundant in nature, renewable, non-toxic, biocompatible and biodegradable. Owing to the presence of positive charges, natural cationic polymers have found important applications in many biological fields, such as drug/gene delivery and tissue engineering. In gene delivery, natural cationic polymers can condense nucleic acids, protect them from degradation, lower the immunogenicity and improve overall transfection efficiency. In drug delivery, cationic functional groups can alter the amphiphilic properties of the polymers to ensure their suitable applications for delivering hydrophobic or protein drugs. After simple chemical modification, the derivatives of natural cationic polymers show improved performance as functional delivery carriers. In this chapter, details on the chemical modification of natural cationic polymers and their applications in gene/drug delivery is discussed.

Cationic BSA Templated Au–Ag Bimetallic Nanoclusters As a Theranostic Gene Delivery Vector for HeLa Cancer Cells

“…Cationic polymers such as chitosan, poly-lysine, etc. have been used to synthesize non-viral gene carriers with superior uptake and mucoadhesive properties attributed to their electrostatic interactions with the cell membrane. − Serum albumin had been an important choice of material in various drug delivery systems due to its non-toxic nature, biodegradability, biocompatibility, and cost effectiveness. For instance, Abraxane, an FDA-approved albumin-based nanoparticle system has been successfully applied for breast cancer.…”