Natural cause mortality in persons with serious mental illness

Dickerson, Faith; Origoni, Andrea; Schroeder, Jennifer R.; Adamos, Maria; Katsafanas, Emily; Khushalani, Sunil; Savage, Christina; Schweinfurth, Lucy; Stallings, Cassie; Sweeney, Kevin; Yolken, Robert H.

doi:10.1111/acps.12880

Cited by 46 publications

(29 citation statements)

References 43 publications

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“…Life-expectancy with BD is reduced by 12-15 years (Chesney et al 2014). Factors associated with this decreased longevity include co-occurring substance abuse, smoking, and being overweight, unmarried, and having limited access to adequate medical care (Hjorthøj et al 2015;Brietzke et al 2017;Dickerson et al 2018). The decreased longevity may be particularly associated with depression (Dickerson et al 2018).…”

Section: General-medical Morbidity and Mortalitymentioning

confidence: 99%

Bipolar depression: a major unsolved challenge

Baldessarini

Vázquez

Tondo

2020

Int J Bipolar Disord

166

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Depression in bipolar disorder (BD) patients presents major clinical challenges. As the predominant psychopathology even in treated BD, depression is associated not only with excess morbidity, but also mortality from co-occurring general-medical disorders and high suicide risk. In BD, risks for medical disorders including diabetes or metabolic syndrome, and cardiovascular disorders, and associated mortality rates are several-times above those for the general population or with other psychiatric disorders. The SMR for suicide with BD reaches 20-times above general-population rates, and exceeds rates with other major psychiatric disorders. In BD, suicide is strongly associated with mixed (agitated-dysphoric) and depressive phases, time depressed, and hospitalization. Lithium may reduce suicide risk in BD; clozapine and ketamine require further testing. Treatment of bipolar depression is far less well investigated than unipolar depression, particularly for long-term prophylaxis. Short-term efficacy of antidepressants for bipolar depression remains controversial and they risk clinical worsening, especially in mixed states and with rapid-cycling. Evidence of efficacy of lithium and anticonvulsants for bipolar depression is very limited; lamotrigine has long-term benefit, but valproate and carbamazepine are inadequately tested and carry high teratogenic risks. Evidence is emerging of short-term efficacy of several modern antipsychotics (including cariprazine, lurasidone, olanzapine-fluoxetine, and quetiapine) for bipolar depression, including with mixed features, though they risk adverse metabolic and neurological effects.

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Section: General-medical Morbidity and Mortalitymentioning

confidence: 99%

Bipolar depression: a major unsolved challenge

Baldessarini

Vázquez

Tondo

2020

Int J Bipolar Disord

166

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“…Concerning the higher prevalence of smoking in schizophrenia, several hypotheses have been presented in neuropharmacological and psychosocial literature ( Mobascher and Winterer, 2008 ; Sagud et al, 2009 ; Winterer, 2010 ; Peckham et al, 2016 ); however, the reason remains still unclear. As smoking habits have been reported to be associated with medical morbidity and mortality in patients with schizophrenia ( Goff et al, 2005a , Goff et al, 2005b ; Dickerson et al, 2018 ), it is important to consider any approach to minimalize the habit.…”

Section: Introductionmentioning

confidence: 99%

Association between lower estimated premorbid intelligence quotient and smoking behavior in patients with schizophrenia

Hidese

Matsuo

Ishida

et al. 2019

Schizophrenia Research: Cognition

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AimWe aimed to investigate the involvement of premorbid intelligence quotient in higher prevalence of smoking in patients with schizophrenia.MethodsParticipants included 190 patients with schizophrenia (mean ± standard deviation age: 37.7 ± 10.8 years; 88 males and 102 females) and 312 healthy individuals (mean ± standard deviation age: 38.1 ± 13.8; 166 males and 146 females), matched for age, sex, and ethnicity (Japanese). Premorbid intelligence quotient was estimated using the Japanese Adult Reading Test and distress symptoms were assessed using the Hopkins Symptom Check List. Current smoking information was collected according to self-declarations.ResultsAs expected, the smoking rate was higher, while mean education level and Japanese Adult Reading Test scores were significantly lower, in patients with schizophrenia than in healthy individuals (p < 0.01). The mean education level and Japanese Adult Reading Test scores were significantly lower in the smoker group than in the non-smoker group in both patients and healthy individuals (p < 0.05). In the patient group alone, Hopkins Symptom Check List subscale and total scores were significantly higher in the smoker group than in the non-smoker group (p < 0.05). A multivariate regression analysis showed that the Japanese Adult Reading Test score was a significant and negative predictor for smoking (p < 0.001, odds ratio = 0.97; 95% confidence interval: 0.96–0.99).ConclusionOur results suggest that lower estimated premorbid intelligence quotient is an important variable in elucidating smoking behavior in humans and may be associated with higher prevalence of smoking in patients with schizophrenia.

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“…An important support to this effort is publications about comorbidity – such as that by Dickerson et al. in this issue of Acta. Such publications will not only help to move research forward and towards new goals: they might also in time – and I hope soon – influences the education of health workers at undergraduate and postgraduate level.…”

mentioning

confidence: 92%