Natural Compounds from Mexican Medicinal Plants as Potential Drug Leads for Anti-Tuberculosis Drugs

Gómez-Cansino, Rocío; Guzmán-Gutiérrez, Silvia Laura; Campos-Lara, María Guadalupe; Espitia-Pinzón, Clara; Reyes‐Chilpa, Ricardo

doi:10.1590/0001-3765201720160298

Cited by 24 publications

(16 citation statements)

References 44 publications

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“…Mexicoʼs outstanding biodiversity and well-conserved knowledge of traditional medicine makes the country a good starting point for such an endeavor. At least 187 species are ethnobotanically used to treat TB-related symptoms, but only onethird of these plants have been experimentally tested against Mycobacterium tuberculosis [5]. The Los Tuxtlas Biosphere Reserve in the state of Veracruz harbors the most important remains of the tropical rainforest that once covered a great part of the Gulf Coast of Mexico.…”

Section: Introductionmentioning

confidence: 99%

Antimycobacterial Activity of Alkaloids and Extracts from Tabernaemontana alba and T. arborea

et al. 2020

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Tuberculosis is the main cause of death from a single infectious agent. Globally, according to the World Health Organization, in 2018, there were an estimated 1.2 million tuberculosis deaths. Moreover, there is a continuous appearance of drug-resistant strains. Thus, development of new antituberculosis medicines should receive high priority. Plant-derived natural products are promising candidates for this purpose. We therefore screened alkaloid extracts obtained from the root and stem barks of the Mexican Apocynaceae species Tabernaemontana alba and Tabernaemontana arborea, as well as the pure alkaloids ibogaine, voacangine, and voacamine, tested for activity against Mycobacterium tuberculosis H37Rv and cytotoxicity to mammalian Vero cells using the resazurin microtiter and the MTT assays, respectively. The extracts were analyzed by GC-MS and HPLC-UV. T. arborea root bark alkaloid extract showed the highest activity against M. tuberculosis (MIC100 = 7.8 µg/mL) of the four extracts tested. HPLC suggested that voacangine and voacamine were the major components. The latter was isolated by column chromatography, and its chemical structure was elucidated by 1H and 13C NMR, and MS. Unambiguous assignation was performed by HSQC, HMBC, and NOESY experiments. Voacamine is a dimeric bis-indole-type alkaloid and is 15 times more potent than the monomeric ibogan-type alkaloids ibogaine and voacangine (MIC100 = 15.6, 250.0, and 250.0 µg/mL, respectively). However, all of these compounds showed cytotoxicity to Vero cells, with a poor selectivity index of 1.00, 0.16, and 1.42, respectively. This is the first report of voacamine activity against M. tuberculosis.

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Section: Introductionmentioning

confidence: 99%

Antimycobacterial Activity of Alkaloids and Extracts from Tabernaemontana alba and T. arborea

et al. 2020

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“…These natural compounds (secondary metabolites) have been utilized and chemically modifi ed by humans since ancient times to treat and cure their diseases [21]. A quick search of the literature (the main stream natural products journals and PhD theses from university libraries) could give an estimate of >10000 unique compounds which have been previously isolated from natural products (fl ora, algae and fauna).…”

Section: Socio-economic Need Of Anti-tb Natural Productsmentioning

confidence: 99%

African Medicinal Plants that Can Control or Cure Tuberculosis

Ifesinachi¹

2018

Int J Pharm Sci Dev Res

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This review contains a compendium of medicinal plants in Africa that can control or cure tuberculosis. A good number of plant secondary metabolites are reported to have antitubercular activity comparable to the existing antitubercular drugs or sometimes even better. Information regarding the chemistry and pharmacology of plants leads to insight into their structure-activity relationship and potency. A welldefi ned strategy is required to exploit these phytomolecules as antitubercular drugs.

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“…3-α-tigloyl-melianol has no toxicity on Vero cells which is very important for further research [16]. [5][6][7][8] South America is another huge area where folk medicine is the main treatment. Allophylus edulis is an endemic plant of the region which is commonly known as a good anti-inflammatory remedy.…”

Section: Extracts and Natural Substances Isolated From Plantsmentioning

confidence: 99%

“…Researchers isolated pure compounds and found that the most active of them was 1'-acetoxychavicol acetate, isolated from Alpina galangal with an MIC value of 0.024 µg/ml [7]. In Mexico, healers use 187 plants to treat respiratory diseases that may be associated with tuberculosis, 63 of which have been assayed for anti-mycobacterial activity [8]. Traditional medicine is simply one approach to treatment and seems to be ineffective, in fact, people from undeveloped areas, without access to medicines and physicians, have to rely on traditional medicinal practitioners.…”

Section: Introductionmentioning

confidence: 99%

Anti-tubercular substances produced by plants

Polak¹,

Kapka‐Skrzypczak²

2017

J Pre Clin Clin Res.

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Tuberculosis is one of the common causes of death worldwide, and according to the World Health Organization, in 2015, about 10.4 mln people globally is suffering from that disease. Despite great development in medicine and discovery of many antimycobacterial drugs, tuberculosis remains an unsolved problem. The populations of countries in Africa, Asia and South America have difficult access to hygiene, medical care and medicines, and they therefore resort to consulting traditional practitioners who mainly use drugs from natural sources which they prepare themselves. Plants are the biggest source of such medicines and are used as extracts, decoctions or powders, often without any evidence of their actual activity. Isolates from plants sometimes contain unknown substances or some second metabolites of microorganisms. In vitro studies have shown that some of these medicines have effective antimycobacterial properties, even against clinical, resistant strains. This is hopeful in the situation where more and more cases of tuberculosis prove to be resistant to standard drugs. Extracts of medicinal plants are often synergistic with synthetic drugs. Substances with insufficient MIC can be a basis for derivatives which have better properties. This thesis summarizes the current international knowledge of the use of plant substances used in the treatment of tuberculosis that could be potential new antituberculous drugs.

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Natural Compounds from Mexican Medicinal Plants as Potential Drug Leads for Anti-Tuberculosis Drugs

Cited by 24 publications

References 44 publications

Antimycobacterial Activity of Alkaloids and Extracts from Tabernaemontana alba and T. arborea

Antimycobacterial Activity of Alkaloids and Extracts from Tabernaemontana alba and T. arborea

African Medicinal Plants that Can Control or Cure Tuberculosis

Anti-tubercular substances produced by plants

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