Natural Course of Children With Dysplastic and Hypoplastic Kidney

Dinçel, Nida; Bicer, Hasan; Gun, Zubeyir Hasan; Mır, Sevgı

doi:10.4021/wjnu122w

Cited by 2 publications

(4 citation statements)

References 22 publications

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“…The abnormal maturation of the kidneys may lead to congenital urinary anomalies such as renal dysplasia and hypoplasia which are common malformations. [ 8 ]…”

Section: Discussionmentioning

confidence: 99%

Congenital Unilateral Hypoplasia of Kidney with Mesonephric Remnants in the Ureter: A Case Report

Singh,

Jain,

Pujani

et al. 2023

Indian Journal of Nephrology

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Mesonephric remnants persist as an appendix of epididymis and paradidymis in efferent ductules in males and skene’s glands and Gartner’s ducts in females. The mesonephric remnant in the renal parenchyma is extremely rare and only a few cases have been reported in the literature. We present a case with a non-functioning atrophic left kidney. Histopathology showed variable-sized ducts filled with colloid-like material surrounded by collagenized stroma. The ureter showed hypertrophied muscle and a few ducts lined by flattened and a few by columnar epithelium resembling epididymis suggestive of mesonephric remnants. IHC for CD10, PAX 8, and GATA3 was positive. A diagnosis of congenital unilateral hypoplasia of kidneys and ureter with mesonephric remnants was given.

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“…The abnormal maturation of the kidneys may lead to congenital urinary anomalies such as renal dysplasia and hypoplasia which are common malformations. [ 8 ]…”

Section: Discussionmentioning

confidence: 99%

Congenital Unilateral Hypoplasia of Kidney with Mesonephric Remnants in the Ureter: A Case Report

Singh,

Jain,

Pujani

et al. 2023

Indian Journal of Nephrology

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“…tarafından fonksiyonel renal doku kitlesinin azalmasının uzun zamanda glomerüler değişikliklere neden olduğunu gösterilmiştir (11,12) . Literatürde tek böbreği olan kişilerde %22,9-48 oranında kompansatris hipertrofi geliştiği bildirilmiş-tir (4,13) . Bu çalışmada, saptanan oran literatür ile uyumu olup, her iki grup arasında kompansatris hipertrofi açısından fark saptanmadı (p=0,1).…”

Section: Discussionunclassified

“…Bu çalışmada, her iki grupta eGFR'na göre %58 oranında hiperfiltrasyon saptandı. Displastik ve hipoplastik hasta grubunda yapılan bir çalışmada, bu oran %29,1 olarak bildirilmiştir (13) . Bu oranın daha düşük olmasının nedeni bildirilen çalışmadaki hastaların %37,5'inin son dönem böbrek yetmezliği olmasından kaynaklanabilir.…”

Section: Discussionunclassified

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Clinical characteristics and follow-up results of unilateral renal agenesis and hypoplasia of children

Evrengül¹,

Ertan²,

Serdaroğlu³

et al. 2016

BUCH

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ÖZAmaç: Az nefron sayısına sahip çocuklarda, yaşamlarının ilerleyen dönemlerinde hipertansiyon, proteinüri ve kronik böbrek yetmezliği gelişme riski yüksektir. Bu renal hasar, glomerüler hiperfiltrasyondam kaynaklanmaktadır. Bu çalışmanın amacı, tek taraflı agenezik ve hipoplazik böbreği olan çocukların klinik özelliklerinin ve izlem sonuçlarının değerlendirilmesidir. Yöntem: Celal Bayar Üniversitesi Tıp Fakültesi ve Dr. Behçet Uz Çocuk Hastanesinde takip edilen, tek taraflı renal agenezisi ve hipoplazisi olan hastaların klinik, radyolojik ve nükleer tıp inceleme bulguları değerlendirildi. Bulgular: Bu çalışma ortalama yaşı 8,9±4 yıl olan 30 (%60) erkek ve 20 (%40) kız hastadan oluşmaktaydı. Yirmi beş hasta renal agenezi, 25 hasta renal hipoplazi tanısı aldı. Laboratuvar incelemesinde ortalama serum kreatinin düzeyi 0,45±0,22 mg/dl ve tahmin edilen glomerüler filtrasyon hızı (eGFR) 144±30,3 ml/dk. idi. Yirmi dokuz (%58) hastada hiperfiltrasyon saptandı. Proteinüri ve hipertansiyonu olan 1 (%4) hasta vardı. On beş (%30) hastada ürolojik anamoli mevcuttu. Sonuç: Bu çalışmada, tek taraflı renal agenezisi ve hipoplazisi olan hastaların serum kreatinin düzeyi normal bulundu. Ancak bu hastaların 29 (%58) hiperfiltrasyon vardı. Hiperfiltasyonu olan çocukların çoğunda yaşamlarının ilerleyen döneminde renal hasar geliştiği için bu çocuk-ların doğumdan itibararen klinik takiplerinin yapılması gerekmektedir.Anahtar kelimeler: Konjenital böbrek hastalıkları, renal agenezi, renal hipoplazi ABSTRACT Objective: Children with an inadequate number of nephrons have an increased risk of developing hypertension, proteinuria and chronic kidney disease in later life. This renal injury is caused by glomerular hyperfiltration. The aim of this study is to evaluate clinical characteristics and follow-up results of the children with unilateral renal agenesis and hypoplasia. Methods: We evaluated the clinical, radiological, and nuclear medicine findings of the children with unilateral agenetic or hypoplastic kidneys who were followed at Celal Bayar University School of Medicine and Dr. Behcet Uz Children's Hospital between 2005 and 2012. Results: The study consisted of 30 (60%) males and 20 (40%) females with a mean age of 8.9±4 years. A total of 25 patients were with renal agenesis and 25 with renal hypoplasia were diagnosed. On laboratory evaluation, mean serum creatinine level was 0.45±0.22 mg/ dl and the mean estimated glomerular filtration rate (eGFR) was 144±30.3 ml/min. 29 patient (58%) had hyperfiltration according to an eGFR. Proteinuria and hypertension were noted in 1 (4%) patient. Urological anomalies were found in 15 patients (30%). Conclusion: Our study has determined that children with unilateral renal agenesis and hypoplasia had normal serum creatinine values. Howewer 29 patients (58%) had hyperfiltration according to eGFR. Because many children with hiperfiltration develop renal injury in later life, we emphasize the need for clinical follow-up in these patients starting at birth.

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Natural Course of Children With Dysplastic and Hypoplastic Kidney

Abstract: Background: The objective of this study was to report the outcomes of children with dysplastic kidney and identify the variables that are independent predictors on the renal involution.

Cited by 2 publications

References 22 publications

Congenital Unilateral Hypoplasia of Kidney with Mesonephric Remnants in the Ureter: A Case Report

Congenital Unilateral Hypoplasia of Kidney with Mesonephric Remnants in the Ureter: A Case Report

Clinical characteristics and follow-up results of unilateral renal agenesis and hypoplasia of children

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