Natural cyclic polypeptides as vital phytochemical constituents from seeds of selected medicinal plants

Abstract

Cyclopolypeptides are among the most predominant biomolecules in nature, especially those derived from plant seeds. This category of compounds has gained extraordinary attention due to remarkable variety of structures and valuable biofunctions. These congeners display enormous variation in terms of both structure and function and are the most significant biomolecules due to their widespread bioproperties. The estrogenic activity, immunosuppressive activity, cytotoxicity, vasorelaxant activity, and other properties possessed by cyclic peptides from seeds of plants make these congeners attractive leads for the drug discovery process. The current study covers the important structural features, structure–activity relationship, synthesis methods, and bioproperties of plant seeds‐originated bioactive peptides from Vaccaria segetalis, Linum usitatissimum, and Goniothalamus leiocarpus, which may prove vital for the development of novel therapeutics based on a peptide skeleton.

Vaccaria segetalis: A Review of Ethnomedicinal, Phytochemical, Pharmacological, and Toxicological Findings

“…Cyclic peptides have been found in several medicinal species such as Pseudostellaria heterophylla Miq., Lycium chinense Mill., and Psammosilene tunicoides , and exhibit a wide range of structure-dependent bioactivities (Tan and Zhou, 2006 ). Cyclic peptides are important components of V. segetalis (Dahiya and Dahiya, 2021 ). With the development and integration of modern medicine and traditional complementary medicine, the roles of cyclic peptides have been further confirmed.…”

Oxidation of Cyclo‐Lino Peptides in Linseed Oils during Storage

“…In the freshly extracted oil, these oxidation products are only found in small amounts. The bioactivities of CLPs have been reviewed by Dahiya et al, [17] while the nomenclature was reviewed by Shim et al [18] as different systems were used by authors in the past. A summary of the nomenclature of the CLPs and the acronyms used in this study are given in Table 1.…”