Natural Deep Eutectic Solvents (NADESs) Combined with Sustainable Extraction Techniques: A Review of the Green Chemistry Approach in Food Analysis

Cannavacciuolo, Ciro; Pagliari, Stefania; Frigerio, Jessica; Giustra, Chiara Maria; Labra, Massimo; Campone, Luca

doi:10.3390/foods12010056

Cited by 72 publications

(28 citation statements)

References 104 publications

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“…Indeed, due to their potential lack of toxicity, NaDESs can be used not only for food extraction and nutraceuticals, but also in pharmaceutical and cosmetic formulations. [59]…”

Section: Safety Of Deep Eutectic Solventsmentioning

confidence: 99%

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Deep Eutectic Solvents: An Eco‐friendly Design for Drug Engineering

et al. 2023

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In the spirit of circular economy and sustainable chemistry, the use of environmentally friendly chemical products in pharmacy has become a hot topic. In recent years, organic solvents have been the subject of a great range of restriction policies due to their harmful effects on the environment and toxicity to human health. In parallel, deep eutectic solvents (DESs) have emerged as suitable greener solvents with beneficial environmental impacts and a rich palette of physico‐chemical advantages related to their low cost and biocompatibility. Additionally, DESs can be accompanied by a remarkable solubilizing effect for several active pharmaceutical ingredients (APIs), thus forming therapeutic DESs (TheDESs). In this work, special attention is paid to DESs, presenting a precise definition, classification, methods of preparation, and characterization. A description of natural DESs (NaDESs), i.e., eutectic solvents present in natural sources, is also reported. Moreover, the present review article is the first one to detail the different approaches for judiciously selecting the constituents of DESs in order to minimize the number of experiments. The role of DESs in the biomedical and pharmaceutical sectors and their impact on the development of successful therapies are also discussed.

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“…Indeed, due to their potential lack of toxicity, NaDESs can be used not only for food extraction and nutraceuticals, but also in pharmaceutical and cosmetic formulations. [59]…”

Section: Safety Of Deep Eutectic Solventsmentioning

confidence: 99%

“…Currently, NaDESs are of great interest as evidenced by numerous recent research papers with a great range of applications. Indeed, due to their potential lack of toxicity, NaDESs can be used not only for food extraction and nutraceuticals, but also in pharmaceutical and cosmetic formulations [59] …”

Section: Safety Of Deep Eutectic Solventsmentioning

confidence: 99%

Deep Eutectic Solvents: An Eco‐friendly Design for Drug Engineering

et al. 2023

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“…Taking into account all these statements and our interest in eco‐friendly products and mw processes (Rosa et al ., 2017; Villa et al ., 2023), the aim of this research was the recovery of bioactive compounds (i.e. polyphenols) from beetroot waste (fresh stalks) by an innovative and eco‐friendly microwave‐mediated NADES procedure that could allow the simultaneous green solvent preparation and matrix extraction, as an alternative and simplification of other NADES extractions reported in the literature (Dai et al ., 2013; Souza et al ., 2022; Cannavacciuolo et al ., 2023). In particular, the main goal was to propose a fast and simple “one‐pot” extractive approach to obtain and screen non‐toxic, bioactive ready‐to‐use ingredients, potentially useful in food, cosmetic, and pharmaceutical fields, consisting of the NADES‐based extractive itself (da Silva et al ., 2021).…”

Section: Introductionmentioning

confidence: 99%

In situ NADES microwave‐mediated extraction of bioactive compounds from Beta vulgaris L. var. rubra waste

Caviglia,

Russo,

Preda

et al. 2024

Int J of Food Sci Tech

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SummaryThe research focused on the recovery of bioactive compounds from beetroot waste (fresh stalks) using an innovative and microwave‐mediated (mw) procedure that could allow the simultaneous eutectic solvent preparation and matrix extraction (in situ mw NADES extraction), as a simplification of more conventional NADES (natural deep eutectic solvents) extractions. The main goal was to propose a fast and simple “one‐pot” extractive approach to obtain and screen non‐toxic, bioactive ready‐to‐use ingredients, potentially useful in food, cosmetic and pharmaceutical fields, meanwhile converting beetroot residues, from worn‐out plant matrices to recycled sources with significant added values. With this purpose, several eutectic mixtures of natural food‐grade hydrogen bond donors (choline chloride or betaine) and hydrogen bond acceptors (fructose, urea, citric acid, and glycerol) were selected and investigated (in opportune ratios) under microwave activation, considering time, temperature, and solvent‐to‐matrix ratio as the influencing variables and the total phenols content recovery as the response. By the in situ NADES microwave method developed, the best results were obtained within 5 min at 70 °C with recoveries of around 0.5 mg of polyphenols for gram of fresh stalks, assessed by the Folin–Ciocalteu test. The suitability of the NADES‐based extractives, as radical scavenging agents, was evaluated using the DPPH assay, which highlighted their good antioxidant activity; moreover, monitoring the betacyanin content by means of UV–vis spectrophotometric analyses, it was evident that NADES provide a relevant stability to the new complexes (up to 3 months) compared to water (24 h). The new in situ process proposed could be also useful for preliminary screenings of different organic matrices, simplifying workup, streamlining the procedures, and reducing costs.

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“…Natural deep eutectic solvent (NADES) is a novel type of eco-friendly solvent that shares some characteristics with ionic liquids and is formed by mixing a quaternary ammonium salt or hydrogen-bond acceptor (HBA) with a hydrogen-bond donor (HBD) [8,9]. NADES are considered one of the most effective green solvents [10] in terms of extractability, stability, and recovery yield, as well as their bioactivity, solubility, and bioavailability. Furthermore, NADES is cheap, affordable, easy to use, and less time-consuming.…”

Section: Introductionmentioning

confidence: 99%

Innovative Green Approach for Extraction of Piperine from Black Pepper Based on Response Surface Methodology

Lwamba

Aboushanab

Ambati

et al. 2023

Sustainable Chemistry

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Bioactive compounds like piperine (alkaloids) offer a variety of health benefits due to their biological and pharmacological potential. Piperine has been revealed to have anti-inflammatory, anti-aging, anti-diabetes, anti-bacterial, anti-ulcer, and anti-carcinogenic characteristics. Recent research has been conducted to extract piperine using effective and environmentally friendly techniques. In this study, we sought to assess the potential and efficacy of natural deep eutectic solvents to extract piperine from black pepper seeds using an ultrasound-assisted extraction technique. A Box–Behnken design combined with response surface methodology was used to evaluate the optimum extraction conditions of piperine. Extraction efficiency was evaluated based on the extraction yields of piperine, antioxidant activity, total polyphenols, and total flavonoids. The results showed that the choline chloride-citric acid-1,2-propylene glycol combination (1:2:2 molar ratio) with 25% (v/v) of water was the most effective at extracting piperine from black pepper. It was found that the extraction yield of piperine was significantly influenced by the liquid–solid ratio and extraction time. The optimal extraction conditions were determined and it was found that antioxidant activities and total polyphenol content in the piperine-rich extracts were remarkably related to the piperine content. The piperine extract purity was found to be 90%. Our results indicate that black pepper could be used as a functional food application.

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Natural Deep Eutectic Solvents (NADESs) Combined with Sustainable Extraction Techniques: A Review of the Green Chemistry Approach in Food Analysis

Cited by 72 publications

References 104 publications

Deep Eutectic Solvents: An Eco‐friendly Design for Drug Engineering

Deep Eutectic Solvents: An Eco‐friendly Design for Drug Engineering

In situ NADES microwave‐mediated extraction of bioactive compounds from Beta vulgaris L. var. rubra waste

Innovative Green Approach for Extraction of Piperine from Black Pepper Based on Response Surface Methodology

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