Natural essential oils as a new therapeutic tool in colorectal cancer

Garzoli, Stefania; Alarcón-Zapata, Pedro; Seitimova, G. A.; Alarcón-Zapata, Barbara; Martorell, Miquel; Sharopov, Farukh; Fokou, Patrick Valère Tsouh; Dize, Darline; Yamthé, Lauve Rachel Tchokouaha; Les, Francisco; Cásedas, Guillermo; López, Víctor; Sharifi‐Rad, Javad; Gürer, Eda Sönmez; Călina, Daniela; Pezzani, Raffaele; Vitalini, Sara

doi:10.1186/s12935-022-02806-5

Cited by 19 publications

(10 citation statements)

References 168 publications

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“…The cell inflammation induction by lipopolysaccharide (LPS) triggers a series of signaling pathways including MAPK and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) ( Li et al, 2016 ; Capó et al, 2021 ; Pezzani et al, 2023 ). MAPKs are involved in the phosphorylation of JNK, ERK and p38 which regulate the expression of MSK 1/2 and then p65 ( Xie et al, 2019 ; Garzoli et al, 2022 ; Li et al, 2023 ). Inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) are also key enzymes involved in inflammation and cell stress, being NO an important regulator of COX-2 expression and activity ( Sharifi-Rad et al, 2022c ; Li et al, 2023 ).…”

Section: Anticancer Mechanisms and Targeting Signaling Pathways By Al...mentioning

confidence: 99%

An updated overview of anticancer effects of alternariol and its derivatives: underlying molecular mechanisms

et al. 2023

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Alternariol is a toxic metabolite of Alternaria fungi and studies have shown multiple potential pharmacological effects. To outline the anticancer effects and mechanisms of alternariol and its derivatives based on database reports, an updated search of PubMed/MedLine, ScienceDirect, Web of Science, and Scopus databases was performed with relevant keywords for published articles. The studies found to suggest that this mycotoxin and/or its derivatives have potential anticancer effects in many pharmacological preclinical test systems. Scientific reports indicate that alternariol and/or its derivatives exhibit anticancer through several pathways, including cytotoxic, reactive oxygen species leading to oxidative stress and mitochondrial dysfunction-linked cytotoxic effect, anti-inflammatory, cell cycle arrest, apoptotic cell death, genotoxic and mutagenic, anti-proliferative, autophagy, and estrogenic and clastogenic mechanisms. In light of these results, alternariol may be one of the hopeful chemotherapeutic agents.

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Section: Anticancer Mechanisms and Targeting Signaling Pathways By Al...mentioning

confidence: 99%

An updated overview of anticancer effects of alternariol and its derivatives: underlying molecular mechanisms

et al. 2023

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“…Digestive cancers represent a group of malignancies that arise from the gastrointestinal tract, with colorectal cancer (CRC) being one of the most prevalent and deadly forms (GBD 2019 Colorectal Cancer Collaborators, 2022; Zlatian et al, 2015); early detection and intervention are paramount as liver or CRC, when identified at a localized stage, has a significantly higher survival rate compared to advanced stages where the disease has metastasized to distant organs (Garzoli et al, 2022). A recent study was designed to explore the effect of β‐sitosterol on enhancing the killing activity of costimulatory cells against gastric cancer.…”

Section: Anticancer Effects and Mechanisms Of β‐Sitosterolmentioning

confidence: 99%

Anticancer activity and other biomedical properties of β‐sitosterol: Bridging phytochemistry and current pharmacological evidence for future translational approaches

Nandi,

Nag,

Khatua

et al. 2023

Phytotherapy Research

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Sterols, including β‐sitosterol, are essential components of cellular membranes in both plant and animal cells. Despite being a major phytosterol in various plant materials, comprehensive scientific knowledge regarding the properties of β‐sitosterol and its potential applications is essential for scholarly pursuits and utilization purposes. β‐sitosterol shares similar chemical characteristics with cholesterol and exhibits several pharmacological activities without major toxicity. This study aims to bridge the gap between phytochemistry and current pharmacological evidence of β‐sitosterol, focusing on its anticancer activity and other biomedical properties. The goal is to provide a comprehensive understanding of β‐sitosterol's potential for future translational approaches. A thorough examination of the literature was conducted to gather relevant information on the biological properties of β‐sitosterol, particularly its anticancer therapeutic potential. Various databases were searched, including PubMed/MedLine, Scopus, Google Scholar, and Web of Science using appropriate keywords. Studies investigating the effects of β‐sitosterol on different types of cancer were analyzed, focusing on mechanisms of action, pharmacological screening, and chemosensitizing properties. Modern pharmacological screening studies have revealed the potential anticancer therapeutic properties of β‐sitosterol against various types of cancer, including leukemia, lung, stomach, breast, colon, ovarian, and prostate cancer. β‐sitosterol has demonstrated chemosensitizing effects on cancer cells, interfering with multiple cell signaling pathways involved in proliferation, cell cycle arrest, apoptosis, survival, metastasis invasion, angiogenesis, and inflammation. Structural derivatives of β‐sitosterol have also shown anti‐cancer effects. However, research in the field of drug delivery and the detailed mode of action of β‐sitosterol‐mediated anticancer activities remains limited. β‐sitosterol, as a non‐toxic compound with significant pharmacological potential, exhibits promising anticancer effects against various cancer types. Despite being relatively less potent than conventional cancer chemotherapeutics, β‐sitosterol holds potential as a safe and effective nutraceutical against cancer. Further comprehensive studies are recommended to explore the biological properties of β‐sitosterol, including its mode of action, and develop novel formulations for its potential use in cancer treatment. This review provides a foundation for future investigations and highlights the need for further research on β‐sitosterol as a potent superfood in combating cancer.

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“…Cancer is a large group of diseases that vary in mode of onset, growth rate, diagnosis, detectability, invasive potential, metastasis, response to treatment and prognosis [122][123][124][125][126]. Numerous studies have also revealed that additional Paeonia constituents may be used to treat breast, lung, and liver cancers and leukaemia.…”

Section: Anticancer and Cytotoxic Propertiesmentioning

confidence: 99%

A comprehensive review on traditional uses, phytochemistry and pharmacological properties of Paeonia emodi Wall. ex Royle: current landscape and future perspectives

et al. 2023

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Paeoniaemodi Wall. ex Royle is commonly known as Himalayan paeony has great importance as a food and medicine. The practice of Paeoniaemodi Wall. ex Royle is very ancient and it is conventionally used for a wide range of illnesses in the folk system of medicine because of its wide beneficial phytochemical profile. The main purpose of the current review was the synthesis of recent data on botany, ethnopharmacology, phytochemistry and potential pharmacological mechanisms of action of Paeoniaemodi Wall. ex Royle, thus offering new prospects for the development of new adjuvant natural therapies. Using scientific databases such as PubMed/MedLine, Scopus, Web of Science, ScienceDirect, Google Scholar, Springer, and Wiley, a comprehensive literature search was performed for Paeoniaemodi Wall. ex Royle. For searching, we used the next MeSH terms: “Biological Product/isolation and purification”, “Biological Products/pharmacology”, “Drug Discovery/methods”, “Ethnopharmacology, Medicine”, “Traditional/methods”, “Paeonia/chemistry”, “Plant Extracts/pharmacology”, “Phytochemicals/chemistry”, “Phytochemicals/pharmacology”, “Plants, Medicinal”. The results of the most recent studies were analyzed and the most important data were summarized in tables and figures. Phytochemical research of Paeoniaemodi Wall. ex Royle has led to the isolation of triterpenes, monoterpenes, phenolic acids, fatty acids, organic compounds, steroids, free radicals and some other classes of primary metabolites. In addition, diverse pharmacological activities like antibacterial, antifungal, anticoagulant, airway relaxant lipoxygenase and beta-glucuronidase inhibiting activity, radical scavenging activity, phytotoxic and insecticidal activities have been reported for Paeoniaemodi Wall. ex Royle. Different bioactive compounds of Paeoniaemodi Wall. ex Royle has proven their therapeutic potential in modern pharmacological and biomedical research to cure numerous gastrointestinal and nervous disorders. In future, further in vitro and in vivo therapeutic studies are required to identify new mechanisms of action, pharmacokinetics studies, and new pharmaceutical formulations for target transport and possible interaction with allopathic drugs. Also, new research regarding quality evaluation, toxicity and safety data in humans is needed.

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Natural essential oils as a new therapeutic tool in colorectal cancer

Cited by 19 publications

References 168 publications

An updated overview of anticancer effects of alternariol and its derivatives: underlying molecular mechanisms

An updated overview of anticancer effects of alternariol and its derivatives: underlying molecular mechanisms

Anticancer activity and other biomedical properties of β‐sitosterol: Bridging phytochemistry and current pharmacological evidence for future translational approaches

A comprehensive review on traditional uses, phytochemistry and pharmacological properties of Paeonia emodi Wall. ex Royle: current landscape and future perspectives

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