Natural Killer Cell Activity and Lymphocyte Function During and After Coronary Artery Bypass Grafting in Relation to the Endocrine Stress Response

Tønnesen, Else; Brinkløv, Morten M.; Christensen, Niels Juel; Olesen, Anne Vingaard; Madsén, Torsten

doi:10.1097/00000542-198710000-00014

Cited by 122 publications

(62 citation statements)

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“…This clinical report confirms the role of adrenaline as a potent stimulator/inducer of NK cell cytotoxicity in vivo [8,11,13]. Furthermore, the results suggest a positive correlation between NK cell activity and the number of circulating Leu 11 + cells.…”

Section: Discussionsupporting

confidence: 81%

“…In a previous study of patients undergoing coronary artery bypass grafting, intubation of the trachea was not accompanied by an increase in plasma adrenaline or noradrenaline concentrations, but by a small but significant decrease [8]. Although plasma catecholamine concentrations increased markedly after intubation of the trachea in the present patient, no comparison is possible because of differences in the underlying diseases and anaesthetic techniques used.…”

Section: Discussioncontrasting

confidence: 66%

“…The relative percentage of NK cells in peripheral blood mononuclear cells was estimated by the use of the monoclonal antibody Leu 11 (Becton Dickinson, California) reacting selectively with NK cells [8].…”

Section: Lymphocyte Subpopulation {Leu 11 + Cells)mentioning

confidence: 99%

See 2 more Smart Citations

Natural Killer Cell Activity in a Patient Undergoing Resection of Phaeochromocytoma

Tønnesen

Knudsen

Nielsen

et al. 1989

British Journal of Anaesthesia

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Section: Discussionsupporting

confidence: 81%

Section: Discussioncontrasting

confidence: 66%

See 1 more Smart Citation

Natural Killer Cell Activity in a Patient Undergoing Resection of Phaeochromocytoma

Tønnesen

Knudsen

Nielsen

et al. 1989

British Journal of Anaesthesia

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“…As far as the end results of basic and clinical research have been to provide decreased morbidity and mortality from an anaesthesia session, immunologic effects of anaesthesia has been one of the less investigated areas. Some immunologic changes were reported mainly after major surgical operations, which rendered further morbidity to the procedures (11,12,13,14). Publications, which investigated immune response in anaesthesia, have not agreed on a consensus that "what immunologic changes occur in a particular narrow space of anaesthesia and which side effects may occur due to these changes?"…”

Section: R Re Es Su Ul Lt Ts Smentioning

confidence: 99%

The Effects of Isoflurane and Sevoflurane on Immune System in Minor Surgical Interventi̇ons

Durlu¹,

Batiislam²,

Özatamer³

2002

Journal of Ankara Medical School

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In the present state of knowledge, anaesthesia and surgery depress immune system by direct effects of anesthetic agents and indirect interaction of hormonal and metabolic changes caused by surgical stress. Every component of immunologic profile can be altered during anaesthesia and sur- - Hematological and most of the immunological measurements were in normal ranges throughout the study and no statistically significant difference was observed between sevoflurane and isoflurane groups. Time related differences observed in each group consisting increases in IgG, B and T lymphocytes and T-helper and decrease in T-suppressor levels with protection of complement levels in isoflurane group. Although the laboratory data showed better immune response for isoflurane, statistical analyses did not support these findings. Even though different aspects of immune system changes have been in the advantage of isoflurane regarding laboratory data, statistical methods did not revealed a meaningful difference in each comparison.K Ke ey y W Wo or rd ds s: Immune Response, Isoflurane, Minor Surgery, Sevoflurane, Ö ÖZ ZE ET T M Mi in nö ör r C Ce er rr ra ah hi i G Gi ir ri iş şi im ml le er rd de e İ İs so of fl lo or ra an n v ve e S Se ev vo of fl lo or ra an nı ın n İ İm mm mü ün n S Si is st te em me e E Et tk ki il le er ri i Anestezi ve cerrahinin immün sisteme olan etkileri uzun süredir bilinmektedir ve immün etkileşim girişimlerin morbiditesini arttırabilmektedir. Prospektif çalışmamızda sık kullanılan inhalasyon anestetikleri sevofloran ve izofloranın minör cerrahi uygulanan hastalarda immunolojik etkilerini karşılaştırmayı planladık. İmmünolojik yetmezliği olmayan ve minör cerrahi girişim uygulanan 44 hasta çalışmaya dahil edildi.Aynı indüksiyon tekniği uygulandıktan sonra 22 hastaya izofloran ve 22 hastaya sevofloran uygulandı.Kan örnekleri preoperatif ve postoperatif 1 ve 3. Günlerde olmak üzere 3 kez alındı. Laboratuvar incelemelerde lökosit sayımı, serum immunglobulinler, kompleman, lenfositler, T-lenfosit ve alt grupları bakıldı. İzofloran ve sevofloran grupları arasında hematolojik ve çoğu immünolojik ölçümler normal sınırlar içindeydi ve istatistiksel fark yoktu.A An na ah ht ta ar r K Ke el li im me el le er r: : İmmün Yanıt, İzofloran, Minor Cerrahi, Sevofloran

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“…The stress response initiates a catabolic state reflected by muscle breakdown, hyperglycemia [7][8][9], altered substrate utilization [10] and altered immune function [11]. The cytokine response may also promote end organ dysfunction and may have an impact on cardiac surgery outcome [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Three Different Epidural Solutions in Cardiac Surgery for Stress Protection

Jean-François¹,

Prieto²,

Basile³

et al. 2009

TOATJ

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Background: Different solutions are possible for thoracic epidural analgesia in cardiac surgery. So far, local anesthetics alone or in combination with either clonidine or opioids have been used. Aims:To determine the stress protection provided by different epidural solutions throughout cardiac surgery.Study Design: A randomized, prospective, double blind study in patients undergoing off-pump coronary artery bypass grafting (OPCAB), randomized in three different groups. Thoracic epidural analgesia was installed more than 1 h before application of heparin at levels of T2 to T4; analgesia was provided by 8 ml of bupivacaine 0.25% 15 min prior to surgery and extubation, and 10 ml/h during and up to 72 h after surgery using one of the following regimens: bupivacaine 0.125% solely, bupivacaine 0.125% with fentanyl 3 g/mL or bupivacaine 0.125% with clonidine 0.6 g/mL. Patients were blockrandomized for one of the three treatments. Cortisol and glucose values were determined before surgery, at extubation and 1h and 3h after surgery. Pain scores were assessed up to 48 h after surgery. Hemodynamic stability was also recorded in form of heart rate, systolic and diastolic blood pressure. Multi-comparison ANOVA and Chi-square test were used to compare the data, presented as mean (SD) or median (25 th and 75 th percentile), P < 0.05.Study Setting: A cardiac surgery unit at a tertiary university hospital.Participants: Forty-two patients undergoing OPCAB were enrolled.Main Results: All patient data as well hemodynamic stability were not different between the three groups. All patients were successfully extubated in theatre immediately after surgery. Pain control was good and not significantly different between the groups. Mean glucose concentrations ± SD before surgery and (significantly higher) 3h after surgery were 5.4 ± 1.0 mmol l -1 and 8.4 ± 1.6 mmol l -1 for bupivacaine alone, 5.2 ± 0.5 mmol l -1 and 8.5 ± 2.2 mmol l -1 for bupivacaine plus fentanyl and 5.5 ± 1.6 mmol l -1 and 9.5 ± 2.1mmol l -1 for bupivacaine and clonidine, respectively. The mean cortisol values ± SD in the pre-operative period and 3h after surgery were 413 ± 162 nmol l -1 and 562 ± 173 nmol l -1 for bupivacaine alone, 393 ± 107 nmol l -1 and 581 ± 265 nmol l -1 for bupivacaine and fentanyl and 409 ± 159 nmol l -1 and 570 ± 160 nmol l -1 for bupivacaine and clonidine, respectively. There were no significant differences between the groups. Conclusions:We conclude that short-term stress protection with TEA is equally effective with solely bupivacaine, bupivacaine with fentanyl or clonidine.

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Natural Killer Cell Activity and Lymphocyte Function During and After Coronary Artery Bypass Grafting in Relation to the Endocrine Stress Response

Cited by 122 publications

References 0 publications

Natural Killer Cell Activity in a Patient Undergoing Resection of Phaeochromocytoma

Natural Killer Cell Activity in a Patient Undergoing Resection of Phaeochromocytoma

The Effects of Isoflurane and Sevoflurane on Immune System in Minor Surgical Interventi̇ons

Comparison of Three Different Epidural Solutions in Cardiac Surgery for Stress Protection

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