Natural Killer Cell Activity in Patients with Prostatic Carcinoma and Its in vivo Boosting with Bacillus Calmette-Gu&amp;eacute;rin

Schwemmer, B.; Lehmer, A.; Hofmann, R.; Braun, Jana D.

doi:10.1159/000281003

Cited by 8 publications

(2 citation statements)

References 10 publications

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“…If the results are promising, the administration of bacterial toxins or BCG, which also should be suitable[163], in two to four weeks intervals should continue to ensure a complete cancer regression and a lack of the relapse. A good regeneration of metastatically affected tissues can be expected to accompany cancer regression.…”

Section: Why the Cancer Cells Survive And How To Reject Them?mentioning

confidence: 99%

Involvement of blood mononuclear cells in the infertility, age-associated diseases and cancer treatment

Bukovský

2016

WJSC

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Blood mononuclear cells consist of T cells and monocyte derived cells. Beside immunity, the blood mononuclear cells belong to the complex tissue control system (TCS), where they exhibit morphostatic function by stimulating proliferation of tissue stem cells followed by cellular differentiation, that is stopped after attaining the proper functional stage, which differs among various tissue types. Therefore, the term immune and morphostatic system (IMS) should be implied. The TCS-mediated morphostasis also consists of vascular pericytes controlled by autonomic innervation, which is regulating the quantity of distinct tissues in vivo. Lack of proper differentiation of tissue cells by TCS causes either tissue underdevelopment, e.g., muscular dystrophy, or degenerative functional failures, e.g., type 1 diabetes and age-associated diseases. With the gradual IMS regression after 35 years of age the gonadal infertility develops, followed by a growing incidence of age-associated diseases and cancers. Without restoring an altered TCS function in a degenerative disease, the implantation of tissue-specific stem cells alone by regenerative medicine can not be successful. Transfused young blood could temporarily restore fertility to enable parenthood. The young blood could also temporarily alleviate aging diseases, and this can be extended by substances inducing IMS regeneration, like the honey bee propolis. The local and/or systemic use of honey bee propolis stopped hair and teeth loss, regressed varicose veins, improved altered hearing, and lowered high blood pressure and sugar levels. Complete regression of stage IV ovarian cancer with liver metastases after a simple elaborated immunotherapy is also reported.

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Section: Why the Cancer Cells Survive And How To Reject Them?mentioning

confidence: 99%

Involvement of blood mononuclear cells in the infertility, age-associated diseases and cancer treatment

Bukovský

2016

WJSC

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“…Early studies documented a reduced activity of NK cells in patients with advanced disease [100,101], which is likely due to a reduced surface NKG2D expression in NK cells [61]. Indirect evidence of a role for NK in PC is provided by the fact that in TRAMP mice dietary intake of sulforaphane, a synthetic analog of cruciferous vegetable-derived L isomer reduces carcinogenesis and pulmonary metastases.…”

Section: Tgfb and Prostate Cancermentioning

confidence: 99%

Prostate cancer, tumor immunity and a renewed sense of optimism in immunotherapy

Rigamonti¹,

Bellone²

2012

Cancer Immunol Immunother

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The recent FDA approval of the first therapeutic vaccine against prostate cancer has revitalized the public interest in the fields of cancer immunology and immunotherapy. Yet, clinical results are modest. A reason for this limited success may reside in the capacity of the tumor to convert inflammation in a tumor-promoting condition and eventually escape immune surveillance. Here we present the main known interactions between the prostate tumor and the immune system, showing how the malignancy can dodge the immune system by also exerting several immunosuppressive mechanisms. We also discuss experimental and clinical strategies proposed to counteract cancer immune evasion and emphasize the importance of implementing appropriate murine models like the transgenic adenocarcinoma of the mouse prostate model for investigating the biology of prostate cancer and novel immunotherapy approaches against it.

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Effect of Estramustine Phosphate (Estracyt) and Diethylstilbestrol on Human Natural Killer Cells In Vitro and In Vivo

Kalland

1985

Experimentelle Urologie

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Natural Killer Cell Activity in Patients with Prostatic Carcinoma and Its in vivo Boosting with Bacillus Calmette-Guérin

Cited by 8 publications

References 10 publications

Involvement of blood mononuclear cells in the infertility, age-associated diseases and cancer treatment

Involvement of blood mononuclear cells in the infertility, age-associated diseases and cancer treatment

Prostate cancer, tumor immunity and a renewed sense of optimism in immunotherapy

Effect of Estramustine Phosphate (Estracyt) and Diethylstilbestrol on Human Natural Killer Cells In Vitro and In Vivo

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