Natural Killer Cell Activity in a Patient Undergoing Resection of Phaeochromocytoma

Tønnesen, Else; Knudsen, Flemming; Nielsen, H.K.; Christensen, Niels Juel

doi:10.1093/bja/62.3.327

Cited by 4 publications

(2 citation statements)

References 9 publications

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“…When adrenaline and cortisol are infused to concentrations of blood occurring during surgery or injuries, they produce similar changes in the immune response to those occurring in the patients (242,243). A correlation between increased natural killer cell levels and activity and increased catecholamine concentrations has been found in patients undergoing operation for phaeochromocytoma (244). A similar correlation seems to occur in volunteers after adrenaline injection (245).…”

Section: A Neuroendocrine Responsementioning

confidence: 86%

Effects of anaesthesia and surgery on the immune response

Salo

1992

Acta Anaesthesiol Scand

310

171

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Alterations have been found to occur in every component of immune response during anaesthesia and surgery. These alterations represent the body's general physiological responses and are mainly dependent on the extent of surgery, as well as other factors such as the patient's age and health status, medication and blood transfusion. Anaesthetic and operative complications have profound effects on these responses. Basically, the immune response to anaesthesia and surgery is a beneficial reaction, needed in local host defences and wound healing and in preventing the body from making autoantibodies against its own tissues. The responses may, however, contribute to the development of postoperative infections and spread of malignant disease. During uncomplicated conventional surgery, the immune response usually passes clinically unnoticed without any harmful effects. Absent responses and excessively high responses, on the other hand, harm the patient. Our understanding of immunological phenomena and our possibilities of controlling mediator activation are now lagging behind the technical advances made in operative treatment. If we want to decrease operative morbidity and mortality to below their present levels, more attention should be directed to immune responses to major surgery, injuries and operative complications with massive mediator release which place the surgical patient at risk. Experimental evidence suggests that results of treatment in injured and operated patients can in the future be improved by controlling immune responses and their mediator systems. Our current level of knowledge of immune responses is already helping us to avoid many immune-mediated complications. However, routine interference with these responses is not indicated.

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Section: A Neuroendocrine Responsementioning

confidence: 86%

Effects of anaesthesia and surgery on the immune response

Salo

1992

Acta Anaesthesiol Scand

310

171

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“…ß-Endorphins are possibly involved; in vitro, these compounds can augment the NK activity [27,28], and this effect is blocked by naloxone [29]. In vivo, after anesthetic exposure, there is a transient intraoperative increase in NK activity [30,31], followed by a postoperative decrease in activity that lasts for several days [5,32]. Therefore, we cannot exclude the possibility of a transient increase of NK activity induced by the anesthetics given to the mothers.…”

Section: Discussionmentioning

confidence: 99%

Natural Killer Cell Activity and Delivery: Possible Influence of Cortisol and Anesthetic Agents

Amici

Gasparoni²,

Chirico³

et al. 1999

Neonatology

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The aim of this study was to evaluate the influence of the method of delivery, the level of cord blood lidocaine, and the cortisol concentration on the cord blood natural killer (NK) activity in the full-term healthy newborn. We studied healthy newborns delivered by elective cesarean section without labor under general anesthesia (n = 24), delivered by cesarean section under epidural anesthesia (n = 21), and delivered vaginally with uncomplicated labor (n = 19). The NK cell activity was significantly lower in newborns delivered by cesarean section under epidural anesthesia than it was in the general anesthesia group, while it was similar to the levels found in vaginally delivered newborns. The cortisol concentration was highest in the vaginal delivery group (589.2 ± 200 mmol/l) and lowest in the general anesthesia group (199.2 ± 81.9 mmol/l). The mean serum lidocaine concentration was 414.1 ± 370 μg/l in the epidural anesthesia group and undetectable in the other groups. In conclusion, our data suggest that the cord blood NK activity was significantly influenced by the method of delivery. This effect could be related to anesthetics given to the mother for general or epidural anesthesia or to the endocrine-metabolic variations observed after different degrees of delivery-related stress. The NK cells being a first-line defense mechanism against viral infections, the results of this study suggest an association with the occurrence of early perinatal infections, especially in preterm infants.

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Immunological aspects of anesthetic management

Tønnesen

1993

Advances in Neuroimmunology

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Natural Killer Cell Activity in a Patient Undergoing Resection of Phaeochromocytoma

Cited by 4 publications

References 9 publications

Effects of anaesthesia and surgery on the immune response

Effects of anaesthesia and surgery on the immune response

Natural Killer Cell Activity and Delivery: Possible Influence of Cortisol and Anesthetic Agents

Immunological aspects of anesthetic management

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