Natural killer cell licensing after double cord blood transplantation is driven by the self-HLA class I molecules from the dominant cord blood

Guillaume, Nicolas; Loiseau, Pascale; Gagne, Katia; Cayuela, Jean‐Michel; Henry, Guylaine; Robin, Marie; Latour, Régis Peffault de; Gluckman, Éliane; Socié, Gérard; Retière, Christelle; Dulphy, Nicolas; Toubert, Antoine

doi:10.3324/haematol.2015.138883

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…Recently, a retrospective study performed on a large cohort of AML patients reported that there was no impact of KIR3DL1/2DS1 or a haplotype-motif-based donor selection algorithm on OS and relapse after unrelated HLA matched HSCTs [151]. In line with HSCT protocols, the impact of KIR-L mismatches was investigated in adult patients after dUCBTs [152][153][154][155][156][157][158]. Once again, conflicting data were reported, which were linked either to the competing KIR models used or the heterogeneity of the patients and treatment modalities.…”

Section: Kir Models Used To Evaluate Nk Cell Alloreactivity and Clinical Outcomes After Allogeneic Hsctmentioning

confidence: 99%

Relevance of Polymorphic KIR and HLA Class I Genes in NK-Cell-Based Immunotherapies for Adult Leukemic Patients

Dubreuil

Chevallier

Retière

et al. 2021

Cancers

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Since the mid-1990s, the biology and functions of natural killer (NK) cells have been deeply investigated in healthy individuals and in people with diseases. These effector cells play a particularly crucial role after allogeneic hematopoietic stem-cell transplantation (HSCT) through their graft-versus-leukemia (GvL) effect, which is mainly mediated through polymorphic killer-cell immunoglobulin-like receptors (KIRs) and their cognates, HLA class I ligands. In this review, we present how KIRs and HLA class I ligands modulate the structural formation and the functional education of NK cells. In particular, we decipher the current knowledge about the extent of KIR and HLA class I gene polymorphisms, as well as their expression, interaction, and functional impact on the KIR+ NK cell repertoire in a physiological context and in a leukemic context. In addition, we present the impact of NK cell alloreactivity on the outcomes of HSCT in adult patients with acute leukemia, as well as a description of genetic models of KIRs and NK cell reconstitution, with a focus on emergent T-cell-repleted haplo-identical HSCT using cyclosphosphamide post-grafting (haplo-PTCy). Then, we document how the immunogenetics of KIR/HLA and the immunobiology of NK cells could improve the relapse incidence after haplo-PTCy. Ultimately, we review the emerging NK-cell-based immunotherapies for leukemic patients in addition to HSCT.

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Section: Kir Models Used To Evaluate Nk Cell Alloreactivity and Clinical Outcomes After Allogeneic Hsctmentioning

confidence: 99%

Relevance of Polymorphic KIR and HLA Class I Genes in NK-Cell-Based Immunotherapies for Adult Leukemic Patients

Dubreuil

Chevallier

Retière

et al. 2021

Cancers

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Impact of Graft-Versus-Graft Natural Killer Cell Alloreactivity on Single Unit Dominance After Double Umbilical Cord Blood Transplantation

et al. 2017

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Natural killer cell licensing after double cord blood transplantation is driven by the self-HLA class I molecules from the dominant cord blood

Cited by 2 publications

References 15 publications

Relevance of Polymorphic KIR and HLA Class I Genes in NK-Cell-Based Immunotherapies for Adult Leukemic Patients

Relevance of Polymorphic KIR and HLA Class I Genes in NK-Cell-Based Immunotherapies for Adult Leukemic Patients

Impact of Graft-Versus-Graft Natural Killer Cell Alloreactivity on Single Unit Dominance After Double Umbilical Cord Blood Transplantation

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