Natural killer cell subsets in cerebrospinal fluid of patients with multiple sclerosis

Rodrı́guez-Martı́n, Eulalia; Picón, Carmen; Costa‐Frossard, Lucienne; Alenda, Raquel; Maza, Susana Sainz de la; Roldán, Ernesto; Espiño, Mercedes; Villar, Luisa M.; Álvarez‐Cermeño, José C.

doi:10.1111/cei.12580

Cited by 56 publications

(50 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The majority of intrathecal NK cells in healthy individuals, MS patients and patients with other neurological diseases are CD56 bright NK cells (21, 37, 38), suggesting that CSF enrichment in CD56 bright NK cells is not MS specific, but rather CNS specific (37). This may reflect organ-specific, rather than blood-specific, tropism of CD56 bright NK cells (39).…”

Section: Possible Role Of Nk Cells In Ms and Its Animal Modelmentioning

confidence: 99%

Regulatory Functions of Natural Killer Cells in Multiple Sclerosis

et al. 2016

View full text Add to dashboard Cite

There is increasing evidence that natural killer (NK) cells exhibit regulatory features. Among them, CD56bright NK cells have been suggested to play a major role in controlling T cell responses and maintaining homeostasis. Dysfunction in NK cell-mediated regulatory features has been recently described in untreated multiple sclerosis (MS), suggesting a contribution to MS pathogenesis. Moreover, biological disease-modifying treatments effective in MS apparently enhance the frequencies and/or regulatory function of NK cells, further pointing toward an immunoprotective role of NK cells in MS. Here, we summarize the current knowledge on the regulatory functions of NK cells, based on their interactions with other cells belonging to the innate compartment, as well as with adaptive effector cells. We review the more recent data reporting disruption of NK cell/T cell interactions in MS and discuss how disease-modifying treatments for MS affect NK cells.

show abstract

Section: Possible Role Of Nk Cells In Ms and Its Animal Modelmentioning

confidence: 99%

Regulatory Functions of Natural Killer Cells in Multiple Sclerosis

et al. 2016

View full text Add to dashboard Cite

show abstract

“…For instance, while uptake of myelin by phagocytes is well known to promote demyelination, it also drives phagocytes toward a less inflammatory, neuroprotective phenotype 33, 34. This suggests that phagocytes play roles in both disease‐promoting and disease‐controlling processes in MS. Other immune cells that may be involved in the pathogenesis of MS include innate‐like lymphocytes, such as γδ T cells, natural killer cells, innate lymphoid cells, and mucosal‐associated invariant T cells 35, 36, 37, 38, 39, 40, 41, 42. Investigation of some of these cell subsets in both MS patients and EAE models yielded contradictory observations, and their role in the disease has not been clearly defined 43…”

Section: Ms and Immune Cellsmentioning

confidence: 99%

Western lifestyle and immunopathology of multiple sclerosis

Matveeva

Bogie

Hendriks

et al. 2018

Annals of the New York Academy of Sciences

View full text Add to dashboard Cite

There is increasing evidence for a sudden and unprecedented rise in the incidence of multiple sclerosis (MS) in Westernized countries over the past decades, emphasizing the role of environmental factors. Among many candidates, rapid changes in dietary habits seem to play a role in the pathogenesis of MS. Here, we summarize and discuss the available evidence for the role of dietary nutrients, such as table salt, fatty acids, and flavonoids, in the development and pathogenesis of MS. We also discuss new and emerging risk factors accompanying Western lifestyle, such as shift work, sleep, and circadian disruption.

show abstract

“…Besides these, several other cells of the innate and adaptive immune system are involved in the pathogenesis of MS. For instance, CD8 + T cells were shown to directly damage axons by the secretion of granzyme B and perforin, [24] and macrophages can contribute to tissue damage by releasing toxic molecules like nitric oxide, oxygen radicals and proinflammatory cytokines [25]. Also B cells [26–28], as well as innate lymphoid cells (ILCs) [29], γ/δ T cells [30] and NK cells [31] play distinct important roles in the autoimmune response. In particular, the recently discovered ILCs, which are tissue-resident lymphoid cells that lack specific antigen receptors, gained interest as new targets for modulating immune tolerance in autoimmune diseases like MS [29].…”

Section: Immune Cells In Multiple Sclerosismentioning

confidence: 99%

Environmental factors in autoimmune diseases and their role in multiple sclerosis

Jörg

Grohme

Erzler

et al. 2016

Cell. Mol. Life Sci.

109

View full text Add to dashboard Cite

An increase in autoimmune diseases poses a socioeconomic challenge worldwide. Predisposing genetic risk has been identified, yet environmental factors make up a significant part of the risk in disease initiation and propagation. Next to improved hygiene and a gross reduction of infections, changes in dietary habits are one of the most evident Western lifestyle factors potentially associated with the increase in autoimmune diseases. Growing evidence suggests that particularly a typical ‘Western diet’, rich in saturated fat and salt and related pathologies can have a profound impact on local and systemic immune responses under physiologic and autoimmune conditions such as in multiple sclerosis (MS). In this review, we discuss recent findings on environmental factors influencing autoimmunity with an emphasis on the impact of ‘Western diet’ on immune homeostasis and gut microbiota in MS.

show abstract

Natural killer cell subsets in cerebrospinal fluid of patients with multiple sclerosis

Abstract: SummaryChanges in blood natural killer (NK) cells, important players of the immune innate system, have been described in multiple sclerosis (MS). We studied percentages and total cell counts of different effector and regulatory NK cells in cerebrospinal fluid (

Cited by 56 publications

References 36 publications

Regulatory Functions of Natural Killer Cells in Multiple Sclerosis

Regulatory Functions of Natural Killer Cells in Multiple Sclerosis

Western lifestyle and immunopathology of multiple sclerosis

Environmental factors in autoimmune diseases and their role in multiple sclerosis

Contact Info

Product

Resources

About