2015
DOI: 10.1016/j.jaci.2014.12.1104
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Natural Killer Cells Regulate Eosinophilic Inflammation in Chronic Rhinosinusitis

Abstract: Eosinophils play a major pathologic role in the pathogenesis of diverse inflammatory diseases including chronic rhinosinusitis (CRS). Dysregulated production of prostaglandin (PG), particularly PGD 2 , is considered to be an important contributing factor to eosinophilic inflammation in CRS primarily through proinflammatory and chemotactic effects on eosinophils. Here, we provide evidence that PGD 2 can promote eosinophilic inflammation through a suppression of Natural killer (NK) cell effector function and NK … Show more

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