Natural Killer T Cells in Patients with Prostatic Carcinoma

Schwemmer, B.

doi:10.1159/000071836

Cited by 6 publications

(4 citation statements)

References 15 publications

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“…In this study, we found that the density of Va24 + NKT cells in colorectal carcinomas increased significantly. Thus far, other groups have reported a remarkable decrease of invariant NKT cells in peripheral blood in patients with advanced cancers (41,42). We observed that Va24 + NKT cells actually existed in the luminal space of tumor-infiltrating vessels.…”

Section: Activation Of Va24 + Natural Killer T Cells In Colorectal Casupporting

confidence: 51%

Increased Intratumor Vα24-Positive Natural Killer T Cells: A Prognostic Factor for Primary Colorectal Carcinomas

Tachibana

Onodera

Tsuruyama

et al. 2005

Clinical Cancer Research

245

183

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Purpose: Human invariant natural killer T (NKT) cells are novel, distinct lymphocyte populations with a restricted T-cell receptor repertoire (Va24-Vh11). They play a pivotal role in immunoregulation and in antitumor activities. This study focused on Va24 + NKT cells in colorectal carcinomas and their clinicopathologic significance. Experimental Design: Va24 + NKT-cell infiltration immunohistochemistry was studied in a total of 103 colorectal carcinoma cases. The degree of NKT-cell infiltration in tumors was evaluated as low (<7 NKTcells/5 HPF) or high (z7 NKT cells/5 HPF). The correlation between the degree of infiltrated Va24 + NKTcells and clinicopathologic variables was studied statistically. Results: A small number of Va24 + NKT cells were found in the normal colorectal mucosa (2.6 F 3.7 cells/5 HPF); however, their number increased remarkably in colorectal carcinomas (15.2 F 16.3 cells/5 HPF; P = 0.0003) and a majority showed phenotype of activation. Higher NKT-cell infiltration was more frequent in women than in men (P = 0.034) and correlated with fewer lymph node metastases (P = 0.042). Patients with high NKT-cell infiltration showed higher overall (P = 0.018) as well as disease-free (P = 0.0006) survival rates. Intratumor NKT-cell infiltration was an independent prognostic factor for the overall (P = 0.033) and disease-free (P = 0.0064) survival rates. Conclusions: Increased infiltration of Va24+ NKT cells was observed in colorectal carcinomas. HigherVa24 + NKT-cell infiltration in colorectal carcinomas was an independent prognostic factor for favorable prognosis.

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Section: Activation Of Va24 + Natural Killer T Cells In Colorectal Casupporting

confidence: 51%

Increased Intratumor Vα24-Positive Natural Killer T Cells: A Prognostic Factor for Primary Colorectal Carcinomas

Tachibana

Onodera

Tsuruyama

et al. 2005

Clinical Cancer Research

245

183

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“…Experimental studies have shown that presented in the context of CD1d, synthetic molecule aGal-Cer strongly stimulates both the immediate and direct anti-tumor effects of human and murine iNKT cells [13,14]. NKT cell numbers are decreased in the peripheral blood of patients with solid tumors such as melanoma, prostate or lung cancer [15][16][17][18], but opinions on their activity diverge, with some authors showing impaired [17,19,20], and others normal, function [15,18].…”

Section: Discussionmentioning

confidence: 99%

CD3+/CD16+CD56+ cell numbers in peripheral blood are correlated with higher tumor burden in patients with diffuse large B-cell lymphoma

Hus¹,

Starosławska²,

Bojarska‐Junak³

et al. 2011

Folia Histochem Cytobiol.

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Diffuse large B-cell lymphoma is the commonest histological type of malignant lymphoma, and remains incurable in many cases. Developing more efficient immunotherapy strategies will require better understanding of the disorders of immune responses in cancer patients. NKT (natural killer-like T) cells were originally described as a unique population of T cells with the co-expression of NK cell markers. Apart from their role in protecting against microbial pathogens and controlling autoimmune diseases, NKT cells have been recently revealed as one of the key players in the immune responses against tumors. The objective of this study was to evaluate the frequency of CD3 + /CD16 + CD56 + cells in the peripheral blood of 28 diffuse large B-cell lymphoma (DLBCL) patients in correlation with clinical and laboratory parameters. Median percentages of CD3 + /CD16 + CD56 + were significantly lower in patients with DLBCL compared to healthy donors (7.37% vs. 9.01%, p = 0.01; 4.60% vs. 5.81%, p = 0.03), although there were no differences in absolute counts. + cells correlated adversely with serum lactate dehydrogenase (R= -445; p < 0.05) which might influence NKT count. These figures suggest a relationship between higher tumor burden and more aggressive disease and decreased NKT numbers. But it remains to be explained whether low NKT cell counts in the peripheral blood of patients with DLBCL are the result of their suppression by the tumor cells, or their migration to affected lymph nodes or organs. (Folia Histochemica et

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“…IFNγ, TNFα, and by eliminating CD1d-expressing tumor cells, thus they represent a potential intriguing therapeutic cellular tool against cancer development and metastasis [162]. In addition, in patients with advanced PCa with elevated prostate-specific antigen (PSA) levels, peripheral blood iNKT cells were decreased in comparison to PCa patients with androgen withdrawal and stable PSA levels [163]. Also, in patients with androgen-independent advanced PCa, peripheral blood iNKT cell frequency was reduced [164], and results from in vitro activated iNKT with α-GalCer and autologous-irradiated PBMCs for 3-4 weeks, showed that PCa patients had iNKT with defective IFNγ production, compared to healthy controls, whereas IL-4 secretion was normal [164].…”

Section: Nk T Cellsmentioning

confidence: 99%

The tumor innate immune microenvironment in prostate cancer: an overview of soluble factors and cellular effectors

Palano

Gallazzi

Cucchiara

et al. 2022

Exploration of Targeted Anti-Tumor Therapy

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Prostate cancer (PCa) accounts as the most common non-cutaneous disease affecting males, and as the first cancer, for incidence, in male. With the introduction of the concept of immunoscore, PCa has been classified as a cold tumor, thus driving the attention in the development of strategies aimed at blocking the infiltration/activation of immunosuppressive cells, while favoring the infiltration/activation of anti-tumor immune cells. Even if immunotherapy has revolutionized the approaches to cancer therapy, there is still a window failure, due to the immune cell plasticity within PCa, that can acquire pro-tumor features, subsequent to the tumor microenvironment (TME) capability to polarize them. This review discussed selected relevant soluble factors [transforming growth factor-beta (TGFβ), interleukin-6 (IL-6), IL-10, IL-23] and cellular components of the innate immunity, as drivers of tumor progression, immunosuppression, and angiogenesis within the PCa-TME.

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Natural Killer T Cells in Patients with Prostatic Carcinoma

Cited by 6 publications

References 15 publications

Increased Intratumor Vα24-Positive Natural Killer T Cells: A Prognostic Factor for Primary Colorectal Carcinomas

Increased Intratumor Vα24-Positive Natural Killer T Cells: A Prognostic Factor for Primary Colorectal Carcinomas

CD3<sup>+</sup>/CD16<sup>+</sup>CD56<sup>+</sup> cell numbers in peripheral blood are correlated with higher tumor burden in patients with diffuse large B-cell lymphoma

The tumor innate immune microenvironment in prostate cancer: an overview of soluble factors and cellular effectors

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