Natural phenolic compounds 1900–2000: a bird's eye view of a century's chemistry

Whiting, Donald A.

doi:10.1039/b003686m

Cited by 101 publications

(10 citation statements)

References 108 publications

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“…Natural products ( e.g. , flavonoids, cannabinoids and rotenoids),1 pharmaceuticals ( e.g. , antiseptics and disinfectants),2 catalysts3 and materials4 all contain phenols in their structures.…”

Section: Introductionmentioning

confidence: 99%

Tetrafluoropyridyl (TFP): a general phenol protecting group readily cleaved under mild conditions

Brittain

Cobb

2019

Org. Biomol. Chem.

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Section: Introductionmentioning

confidence: 99%

Tetrafluoropyridyl (TFP): a general phenol protecting group readily cleaved under mild conditions

Brittain

Cobb

2019

Org. Biomol. Chem.

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“…Bisphenols constitute an important class of molecules with utility as both complex molecule precursors and biologically active natural products. , Such biologically active compounds often incorporate the bisphenol biaryl motif as part of a polycyclic system (Figure A) . Other phenol-containing natural products arise from the direct oxidative coupling of tethered free phenols to afford a phenol-dienone motif (Figure B,C). , Since the discovery that direct phenol oxidation plays a critical role in the biosynthesis of such compounds, − analogous reagent-based approaches have been of considerable interest for their potential application in the synthesis of plant metabolites.…”

mentioning

confidence: 99%

Vanadium-Catalyzed Oxidative Intramolecular Coupling of Tethered Phenols: Formation of Phenol-Dienone Products

Gilmartin

Kozlowski

2020

Org. Lett.

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A mild and efficient method for the vanadium-catalyzed intramolecular coupling of tethered free phenols is described. The corresponding phenol-dienone products are prepared directly in good yields with low catalyst loadings. Electronically diverse tethered phenol precursors are well tolerated, and the catalytic method was effectively applied as the key step in syntheses of three natural products and a synthetically useful morphinan alkaloid precursor.

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“…Flavanols are characterized by the presence of flavan-3-ol as a monomeric unit. Flavanols are usually divided in monomers (or catechins) and condensed tannins (dimers, trimers, oligomers, and polymers)[ 148 ]. The group of catechins is composed by flavanols with catechin, epicatechin, gallocatechin, epigallocatechin, and diverse specific gallic acid esters at the 3-OH position.…”

Section: Flavanolsmentioning

confidence: 99%

Therapeutic potential of flavonoids in inflammatory bowel disease: A comprehensive review

Salaritabar

Darvishi

Hadjiakhoondi

et al. 2017

WJG

160

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The inflammatory process plays a central role in the development and progression of numerous pathological situations, such as inflammatory bowel disease (IBD), autoimmune and neurodegenerative diseases, metabolic syndrome, and cardiovascular disorders. IBDs involve inflammation of the gastrointestinal area and mainly comprise Crohn’s disease (CD) and ulcerative colitis (UC). Both pathological situations usually involve recurring or bloody diarrhea, pain, fatigue and weight loss. There is at present no pharmacological cure for CD or UC. However, surgery may be curative for UC patients. The prescribed treatment aims to ameliorate the symptoms and prevent and/or delay new painful episodes. Flavonoid compounds are a large family of hydroxylated polyphenolic molecules abundant in plants, including vegetables and fruits which are the major dietary sources of these compounds for humans, together with wine and tea. Flavonoids are becoming very popular because they have many health-promoting and disease-preventive effects. Most interest has been directed towards the antioxidant activity of flavonoids, evidencing a remarkable free-radical scavenging capacity. However, accumulating evidence suggests that flavonoids have many other biological properties, including anti-inflammatory, antiviral, anticancer, and neuroprotective activities through different mechanisms of action. The present review analyzes the available data about the different types of flavonoids and their potential effectiveness as adjuvant therapy of IBDs.

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Natural phenolic compounds 1900–2000: a bird's eye view of a century's chemistry

Cited by 101 publications

References 108 publications

Tetrafluoropyridyl (TFP): a general phenol protecting group readily cleaved under mild conditions

Tetrafluoropyridyl (TFP): a general phenol protecting group readily cleaved under mild conditions

Vanadium-Catalyzed Oxidative Intramolecular Coupling of Tethered Phenols: Formation of Phenol-Dienone Products

Therapeutic potential of flavonoids in inflammatory bowel disease: A comprehensive review

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