Natural polyhydroxyalkanoate–gold nanocomposite based biosensor for detection of antimalarial drug artemisinin

Phukon, Pinkee; Radhapyari, Keisham; Konwar, Bolin Kumar; Khan, Raju

doi:10.1016/j.msec.2014.01.019

Cited by 42 publications

(20 citation statements)

References 51 publications

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“…100,106 Enzymes are also used as labels attached to antigens, antibodies and oligonucleotides with a specific sequence providing affinity-based sensors. 100,106 Enzymes are also used as labels attached to antigens, antibodies and oligonucleotides with a specific sequence providing affinity-based sensors.…”

Section: Recognition Receptors Based Electrochemical Analysis Of Antisupporting

confidence: 75%

“…Debnath et al reported a differential pulse polarographic (DPP) method for the determination of ARN. The method was simple and did not require any special separation technique or 100 Recently, a molecularly imprinted membrane based sensor was fabricated for analysis of ARN. Also, Hg is poisonous and hence, it needs to be carefully handled.…”

Section: Artemisinin (Arn) Is a Sesquiterpene Lactone Endoperoxide Thmentioning

confidence: 99%

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Research progress in electroanalytical techniques for determination of antimalarial drugs in pharmaceutical and biological samples

et al. 2016

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Section: Recognition Receptors Based Electrochemical Analysis Of Antisupporting

confidence: 75%

Section: Artemisinin (Arn) Is a Sesquiterpene Lactone Endoperoxide Thmentioning

confidence: 99%

Research progress in electroanalytical techniques for determination of antimalarial drugs in pharmaceutical and biological samples

et al. 2016

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“…Moreover, PHA-graft-graphene demonstrates an increased electrical conductivity with lower critical filing content, when compared to other graphene-based blends. Lately, an electrochemical biosensor based on gold nanoparticles and an enzyme containing PHA/AuNPs/HRP/ITO was prepared with high sensitivity and selective electrochemical properties for the detection of artemisinin and spiked human serum [ 63 ]. Nanocellulose is a class of carbon nanomaterials with further two classes based on their morphology—cellulose nanofibrils (CNFs) and cellulose nanocrystals (CNCs).…”

Section: Applications Of Pha and Its Nanocomposites As A Potentialmentioning

confidence: 99%

Microbial Polyhydroxyalkanoates Granules: An Approach Targeting Biopolymer for Medical Applications and Developing Bone Scaffolds

et al. 2021

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Microbial polyhydroxyalkanoates (PHA) are proteinaceous storage granules ranging from 100 nm to 500 nm. Bacillus sp. serve as unique bioplastic sources of short-chain length and medium-chain length PHA showcasing properties such as biodegradability, thermostability, and appreciable mechanical strength. The PHA can be enhanced by adding functional groups to make it a more industrially useful biomaterial. PHA blends with hydroxyapatite to form nanocomposites with desirable features of compressibility. The reinforced matrices result in nanocomposites that possess significantly improved mechanical and thermal properties both in solid and melt states along with enhanced gas barrier properties compared to conventional filler composites. These superior qualities extend the polymeric composites’ applications to aggressive environments where the neat polymers are likely to fail. This nanocomposite can be used in different industries as nanofillers, drug carriers for packaging essential hormones and microcapsules, etc. For fabricating a bone scaffold, electrospun nanofibrils made from biocomposite of hydroxyapatite and polyhydroxy butyrate, a form of PHA, can be incorporated with the targeted tissue. The other methods for making a polymer scaffold, includes gas foaming, lyophilization, sol–gel, and solvent casting method. In this review, PHA as a sustainable eco-friendly NextGen biomaterial from bacterial sources especially Bacillus cereus, and its application for fabricating bone scaffold using different strategies for bone regeneration have been discussed.

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“…PNCs are also frequently used for monitoring pharmaceutical drugs. Phukon et al reported a polyhydroxyalkanoate (PHOA)–gold nanocomposite for artemisinin determination [323]. Artemisinin is a potent antimalarial drug.…”

Section: Organic Nanomaterials Applications For Healthcare Biosensingmentioning

confidence: 99%

Nanomaterials for Healthcare Biosensing Applications

Pirzada

Altıntaş

2019

Sensors

188

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In recent years, an increasing number of nanomaterials have been explored for their applications in biomedical diagnostics, making their applications in healthcare biosensing a rapidly evolving field. Nanomaterials introduce versatility to the sensing platforms and may even allow mobility between different detection mechanisms. The prospect of a combination of different nanomaterials allows an exploitation of their synergistic additive and novel properties for sensor development. This paper covers more than 290 research works since 2015, elaborating the diverse roles played by various nanomaterials in the biosensing field. Hence, we provide a comprehensive review of the healthcare sensing applications of nanomaterials, covering carbon allotrope-based, inorganic, and organic nanomaterials. These sensing systems are able to detect a wide variety of clinically relevant molecules, like nucleic acids, viruses, bacteria, cancer antigens, pharmaceuticals and narcotic drugs, toxins, contaminants, as well as entire cells in various sensing media, ranging from buffers to more complex environments such as urine, blood or sputum. Thus, the latest advancements reviewed in this paper hold tremendous potential for the application of nanomaterials in the early screening of diseases and point-of-care testing.

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Natural polyhydroxyalkanoate–gold nanocomposite based biosensor for detection of antimalarial drug artemisinin

Cited by 42 publications

References 51 publications

Research progress in electroanalytical techniques for determination of antimalarial drugs in pharmaceutical and biological samples

Research progress in electroanalytical techniques for determination of antimalarial drugs in pharmaceutical and biological samples

Microbial Polyhydroxyalkanoates Granules: An Approach Targeting Biopolymer for Medical Applications and Developing Bone Scaffolds

Nanomaterials for Healthcare Biosensing Applications

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