Natural polysaccharide-based composites for drug delivery and biomedical applications

Muhamad, Ida Idayu; Lazim, Nurul Asmak Md; Selvakumaran, Suguna

doi:10.1016/b978-0-12-817055-7.00018-2

Cited by 18 publications

(16 citation statements)

References 55 publications

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“…Attempts are being made to obtain completely new materials or to modify already known components to improve their properties. In recent years, interest in polysaccharides and materials based on these biopolymers has increased significantly [ 1 , 2 ]. Apart from biocompatibility and biodegradability, polysaccharides are susceptible to chemical modification, which allows their structure and properties to be tailored into the form required for their further use [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Crosslinking of Chitosan with Dialdehyde Chitosan as a New Approach for Biomedical Applications

Węgrzynowska-Drzymalska

Grebicka

Mlynarczyk

et al. 2020

Materials

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Materials based on natural high molecular compounds are particularly interesting for biomedical applications. It is known that the cross-linking agent used for preparation of biomacromolecule-based materials is as important as used biopolymer. Therefore, natural cross-linkers containing reactive carbonyl groups are of great interest especially for modifying properties of natural polysaccharides. One of the most popular cross-linking agents is glutaraldehyde. Nevertheless, the unreacted particles can be released from the cross-linked material and cause cytotoxic effects. This can be eliminated when using a cross-linker based e.g., on polysaccharides. This article describes quick and efficient synthesis of dialdehyde chitosan (DACS) and its application for the preparation of chitosan films. Materials obtained with different amount of DACS were fully characterized in terms of structure and surface morphology. Thermal and mechanical properties as well as hydrophilic character were also examined. The results obtained were compared with the materials obtained by cross-linking chitosan with low molecular weight glutaraldehyde and high molecular weight cross-linking agent based on polysaccharide–dialdehyde starch. Toxicity of all obtained materials was tested using the Microtox® test. It has been shown that due to better mechanical, thermal and surface properties as well as lower toxicity, dialdehyde chitosan is a very promising crosslinking agent.

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Section: Introductionmentioning

confidence: 99%

Crosslinking of Chitosan with Dialdehyde Chitosan as a New Approach for Biomedical Applications

Węgrzynowska-Drzymalska

Grebicka

Mlynarczyk

et al. 2020

Materials

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“…Since the last century, polysaccharides have found their place in the biomedical fields [ 15 ]. Owing to many properties of polysaccharides like biodegradability, biocompatibility, non-immunogenicity, and enhanced solubility and stability.…”

Section: Polysaccharides Applicationmentioning

confidence: 99%

“…Natural polysaccharides have been widely used in nanomaterials for controlling inflammatory pathologies [ 15 ] , and were experimentally tested for their anti-inflammatory activities [ 94 ]. The anti-inflammatory effect of polysaccharides could be through one of these mechanisms, e.g., the anti-inflammatory activity of TCM polysaccharides is mainly due to the inhibition of the expression of the chemotactic factor and adherence factor, as well as the activities of key enzymes in the inflammation process [ 19 ].…”

Section: Polysaccharides Applicationmentioning

confidence: 99%

“…Polysaccharides, the most form of carbohydrates that existed in nature [ 14 ], can be defined according to their chemical structure, which contains monosaccharides units that linked by glycosidic bonds [ 15 , 16 ], they are either sugars residues that glycosidically linked together or bonded covalently to other structures like peptides, amino acids, and lipids. Homopolysaccharides are homoglycans that consist of the same monosaccharides, whereas heteropolysaccharides are heteroglycans that consist of different monosaccharides (Fig.…”

Section: Introductionmentioning

confidence: 99%

“…Chemical modifications such as grafting, cross-linking, complexation, and covalent coupling add more potentialities as drug delivery and subsequently improve therapeutic efficacy [ 4 ]. They can also be a suitable choice for the replacement of some excipients or synthetic polymers [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

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Polysaccharides; Classification, Chemical Properties, and Future Perspective Applications in Fields of Pharmacology and Biological Medicine (A Review of Current Applications and Upcoming Potentialities)

2021

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Polysaccharides are essential macromolecules which almost exist in all living forms, and have important biological functions, they are getting more attention because they exhibit a wide range of biological and pharmacological activities, such as anti-tumour, immunomodulatory, antimicrobial, antioxidant, anticoagulant, antidiabetic, antiviral, and hypoglycemia activities, making them one of the most promising candidates in biomedical and pharmaceutical fields. Polysaccharides can be obtained from many different sources, such as plants, microorganisms, algae, and animals. Due to their physicochemical properties, they are susceptible to physical and chemical modifications leading to enhanced properties, which is the basic concept for their diverse applications in biomedical and pharmaceutical fields. In this review, we will give insight into the most recent updated applications of polysaccharides and their potentialities as alternatives for traditional and conventional therapies. Challenges and limitations for polysaccharides in pharmaceutical utilities are discussed as well.

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Polysaccharide-Based Composites for Biomedical Applications

Alves

Gonçalves

Gil

2021

Materials Horizons: From Nature to Nanomaterials

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Natural polysaccharide-based composites for drug delivery and biomedical applications

Cited by 18 publications

References 55 publications

Crosslinking of Chitosan with Dialdehyde Chitosan as a New Approach for Biomedical Applications

Crosslinking of Chitosan with Dialdehyde Chitosan as a New Approach for Biomedical Applications

Polysaccharides; Classification, Chemical Properties, and Future Perspective Applications in Fields of Pharmacology and Biological Medicine (A Review of Current Applications and Upcoming Potentialities)

Polysaccharide-Based Composites for Biomedical Applications

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