Natural polysaccharides with different conformations: extraction, structure and anti-tumor activity

Lyu, Fengzhi; Xu, Xiaojuan; Zhang, Lina

doi:10.1039/d0tb01713b

Cited by 60 publications

(21 citation statements)

References 135 publications

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“…Natural polysaccharides have attracted more and more interest in food and drug fields due to their physical properties and functions, such as antitumor and immune regulation . Polysaccharide colanic acid (CA) is produced by some enterobacteria and plays a crucial role in adaptation to the external environment. , CA produced by gut microbes can prolong the host’s longevity, indicating that CA has senescence retarding functions.…”

Section: Introductionmentioning

confidence: 99%

Colanic Acid: Biosynthetic Overproduction by Engineering Escherichia coli and Physical Property Characterization

Qiao

Zhan

Tan

et al. 2021

J. Agric. Food Chem.

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Colanic acid has promising applications in food, cosmetic, and healthcare fields. In this study, a recombinant WQM003/pRAU was constructed by deleting genes lon and hns and overexpressing genes rcsA and galU in E. coli MG1655Δ(L-Q). After systematic optimization of fermentation conditions, colanic acid yield in WQM003/pRAU reached 19.79 g/L, the highest yield reported so far. The colanic acid produced by WQM003/pRAU was purified and its structure and physical properties were determined. This colanic acid shows a triple-helical structure and is stable up to 102 °C, and its melting temperature is 253.9 °C. This colanic acid shows a sphere-like chain conformation in aqueous solution. The viscosity of this colanic acid solution is related to concentration, shear rate, salt, temperature, and pH. At high concentrations, this colanic acid shows both viscous and elastic behaviors. These results suggest that the colanic acid produced by WQM003/pRAU has broad application prospects.

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Section: Introductionmentioning

confidence: 99%

Colanic Acid: Biosynthetic Overproduction by Engineering Escherichia coli and Physical Property Characterization

Qiao

Zhan

Tan

et al. 2021

J. Agric. Food Chem.

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“…The extract is a complex mixture of pigments, proteins, inorganic salts, lignin, bioactive compounds, etc. ( 33 ). The impurities need to be removed to identify the polysaccharides' structure and functional activity ( 34 ).…”

Section: Extraction Isolation and Purification Of Polysaccharidesmentioning

confidence: 99%

Polysaccharides as Potential Anti-tumor Biomacromolecules —A Review

et al. 2022

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Cancer, as one of the most life-threatening diseases, has attracted the attention of researchers to develop drugs with minimal side effects. The bioactive macromolecules, such as the polysaccharides, are considered the potential candidates against cancer due to their anti-tumor activities and non-toxic characteristics. The present review provides an overview on polysaccharides' extraction, isolation, purification, mechanisms for their anti-tumor activities, structure-activity relationships, absorption and metabolism of polysaccharides, and the applications of polysaccharides in anti-tumor therapy. Numerous research showed extraction methods of polysaccharides had a significant influence on their activities. Additionally, the anti-tumor activities of the polysaccharides are closely related to their structure, while molecular modification and high bioavailability may enhance the anti-tumor activity. Moreover, most of the polysaccharides exerted an anti-tumor activity mainly through the cell cycle arrest, anti-angiogenesis, apoptosis, and immunomodulation mechanisms. Also, recommendations were made to utilize the polysaccharides against cancer.

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“…Traditional solvent-based methods are often combined with physical extraction methods to improve the yield and purity. Moreover, extraction and purification methods significantly alter the functional and physicochemical properties of the polysaccharide [241]. Therefore, extraction and purification methods that yield lower chemical contamination and does not alter physicochemical properties of the polysaccharide should be chosen.…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

Biomedical applications of polysaccharide nanoparticles for chronic inflammatory disorders: Focus on rheumatoid arthritis, diabetes and organ fibrosis

Allawadhi

Singh

Govindaraj

et al. 2022

Carbohydrate Polymers

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Natural polysaccharides with different conformations: extraction, structure and anti-tumor activity

Abstract: Natural polysaccharides as sustainable polymers are rich in source with good biological safety and various biological functions, which are important research topics in the fields of food and medicine. However,...

Cited by 60 publications

References 135 publications

Colanic Acid: Biosynthetic Overproduction by Engineering Escherichia coli and Physical Property Characterization

Colanic Acid: Biosynthetic Overproduction by Engineering Escherichia coli and Physical Property Characterization

Polysaccharides as Potential Anti-tumor Biomacromolecules —A Review

Biomedical applications of polysaccharide nanoparticles for chronic inflammatory disorders: Focus on rheumatoid arthritis, diabetes and organ fibrosis

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