2023
DOI: 10.1002/biof.2031
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Natural product fargesin interferes with H3 histone lactylation via targeting PKM2 to inhibit non‐small cell lung cancer tumorigenesis

Zizhang Guo,
Yeqing Tang,
Shunshun Wang
et al.

Abstract: Non‐small cell lung cancer (NSCLC) is one of the most common malignant tumors. There is an urgent need to find more effective drugs that inhibit NSCLC. Fargesin (FGS) has demonstrated anti‐tumor effects; however, its efficacy and the molecular mechanism of inhibiting NSCLC are unclear. Herein, we investigated FGS’ inhibitory effects on NSCLC by CCK8 and EdU assays and cell cycle analysis of A549 cells in vitro and in a nude mouse tumor transplantation model in vivo. FGS (10–50 μM) significantly inhibited cell … Show more

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