Natural Products as A Promising Therapy for SARS COV-2; An Overview

Abstract

Recently emerging pandemic SARS CoV-2 conquered our world since December 2019. Continuous efforts have been done to find out effective immunization and precise treatment stetratigies A way from therapeutic options that were tried in SARS CoV-2, an increased attention is directed to predict natural products and mainly phytochemicals as collaborative measures for this crisis. In this review, most of the mentioned compounds specially flavonoids (biacalin, hesperidin, quercetin, luteolin,, and phenolic (resveratrol, curcumin, and theaflavin) exert their effect through interfering with the action of one or more of this proteins (spike protein, papain like protease, 3 chymotrypsin like cysteine protease, and RNA dependent RNA 
 polymerase) that are involved in viral life cycle beside the anti-inflammatory effect of these compounds. The triterpenoids (celastrol, escin and glycyrrhizin) and the alkaloids (lycorine and cepharanthine) mediated their effect mainly through anti-inflammatory activity. Glycyrrhetinic acid (glycyrrhizin metabolite) dawn regulates ACE 2, and reduces protease expression, thus reduce viral entry. This review may be representing an initial step in long path for designing the successful and effective treatment or vaccine for this pandemic.

Phytochemical Elucidation and Effect of Maesa indica (Roxb.) Sweet on Alleviation of Potassium Dichromate-Induced Pulmonary Damage in Rats

“…Apigenin administration reduces the biochemical parameters of oxidative stress and inflammation, improves oxygenation, and decreases lung edema in acute lung injuries in mice by inhibiting inflammation and oxidative stress [56]. According to [57], apigenin, quercetin, and luteolin were confirmed to have antioxidant effects. Kaempferol has proved to be a strong antioxidant, and it could significantly reduce the damage caused by lung ischemia-reperfusion injuries by inhibiting the release of inflammatory factors including interleukin lung ischemia-reperfusion injury and tumor necrosis factor α into the broncho-alveolar lavage fluid and reducing oxidative stress reactions [58].…”