Natural products as a source of Coronavirus entry inhibitors
Dávid Szabó,
Andrew Crowe,
Cyril Mamotte
et al.
Abstract:The COVID-19 pandemic has had a significant and lasting impact on the world. Four years on, despite the existence of effective vaccines, the continuous emergence of new SARS-CoV-2 variants remains a challenge for long-term immunity. Additionally, there remain few purpose-built antivirals to protect individuals at risk of severe disease in the event of future coronavirus outbreaks. A promising mechanism of action for novel coronavirus antivirals is the inhibition of viral entry. To facilitate entry, the coronav… Show more
O-Alkylated and acylated quercetin derivatives were found to inhibit SARS-CoV-2 S:ACE2 interaction in vitro and exhibited low hepato-, nephro-, and cardiotoxicity.
O-Alkylated and acylated quercetin derivatives were found to inhibit SARS-CoV-2 S:ACE2 interaction in vitro and exhibited low hepato-, nephro-, and cardiotoxicity.
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