Natural Products as a Source for Novel Analgesic Compounds

Abdel-Rahman, Rehab F.

doi:10.5772/66770

Cited by 9 publications

(6 citation statements)

References 73 publications

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“…Group 2 was administered the standard diclofenac at a dose of 50 mg/kg (i.p.). 13 Groups 3-6 were injected with the tested doses of eriocitrin (5,10,15, and 30 mg/kg), respectively. After an interval of 20 minutes, all the animals were intraperitoneally injected with a 1% acetic acid solution and the number of abdominal constrictions were counted after 10 minutes of acetic acid injection and continued for an additional 20 minutes.…”

Section: Acetic Acid-induced Abdominal Constrictions Testmentioning

confidence: 99%

“…10,14 Different chemical moieties having potent antinociceptive effects have been obtained from natural sources, resulting in novel lead compound classes for designing of analgesic drugs. 15,16 Among natural compounds, flavonoids are considered important phytochemical classes that displayed distinct pharmacological properties. [17][18][19] The current necessity for additional safe analgesic drugs having lessened side-effects can be efficiently covered by investigating both natural and synthetic flavonoids for their pain reducing properties.…”

Section: Introductionmentioning

confidence: 99%

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<p>Antinociceptive Effect of the Citrus Flavonoid Eriocitrinon Postoperative Pain Conditions</p>

Alghamdi¹

2020

JPR

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Background: Postoperative pain remains a major clinical problem as there are limited analgesic strategies that have been proven to be effective in preventing and relieving this type of pain. Natural products, including flavonoids, have distinct pharmacological properties and play an important role in the discovery of analgesic drugs. Materials and Methods: In this study, the flavonoid eriocitrin (eriodictyol 7-O-rutinoside), which is the main flavonoid in lemon fruit (Citrus limon), was mechanistically investigated for its prospective antinociceptive effect in a mouse model of postoperative pain. The antinociceptive property was evaluated by utilizing both tonic (acetic acid-induced writhing behavior) and phasic (hot-plate) nociception modalities. The hindpaw incisional surgery was performed and hyperalgesia was assessed using von Frey filaments. Results: The tested doses of eriocitrin significantly attenuated (P<0.01, P<0.001) the chemically-induced tonic visceral nociception (5, 10, 15, and 30 mg/kg) and acute phasic thermal nociception (10, 15, and 30 mg/kg). A significant dose-dependent reduction in the incisional nociceptive hyperalgesia was exhibited by eriocitrin, with a marked antinociception observed at doses of 15 mg/kg (P<0.05 during 30-60 minutes) and 30 mg/kg (P<0.05, P<0.01 during 30-120 minutes). Conclusion: The antinociceptive effect of eriocitrin (30 mg/kg) was strongly blocked by the antagonists of the opioid receptor, naltrexone, and GABA A receptor, bicuculline, thereby suggesting the involvement of opioidergic and GABAergic mechanisms in the nociception, reducing proclivity of eriocitrin during transmission of incisional nociception. These results concluded that eriocitrin has a potent antinociceptive effect in postoperative pain conditions, probably mediated through opioid and GABA A receptors.

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Section: Acetic Acid-induced Abdominal Constrictions Testmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

<p>Antinociceptive Effect of the Citrus Flavonoid Eriocitrinon Postoperative Pain Conditions</p>

Alghamdi¹

2020

JPR

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“…Psychological treatment involves the use of aromatherapy, behavioural treatment, and meditation [7]. As for natural ingredients consumption, it is considered as a great potential for the discovery of pain relief drugs due to less to no side effects and has been reported to be able to relieve pain [8,9]. Based on our literature review, some research reported the effects of red ginger and warm water in reducing labor pain.…”

Section: Introductionmentioning

confidence: 99%

The Role of Red Ginger and Warm Water in Relieving Labor Pain

MINTARSIH¹,

ROHMATIN²,

Sahlan

2022

Int J App Pharm

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Objective: The purpose of this study was to compare the efficacy of red ginger and warm water in relieving labor pain at the first stage of the active phase by applying two methods of administration, which were drinking and compressing. Methods: Two-group pre-test-the post-test design was conducted, and 60 respondents were chosen by using purposive sampling. The respondents were divided into four groups consisting of 15 respondents each. Each group was given a different intervention. The interventions were red ginger tea consumption (group A), warm water consumption (group B), red ginger compress (group C), or warm water compress (group D). The data analysis was done by univariate and bivariate analysis through Wilcoxon and Mann Whitney tests. Results: Based on olaboristical analysis, the Mann Whitney (Z) value was-4.261 and-3.240 with a p-value equal to 0.000 and 0.001 for the drinking and compress method, respectively. This indicated that there was a significantly different effect of red ginger and warm water on the labor pain reduction at the first stage of the active phase. Furthermore, comparing the two methods, the greater Z value of red ginger tea consumption was found in comparison to the Z value of red ginger compress. Conclusion: Red ginger tea consumption was more effective compared to red ginger compress in reducing the labor pain at the first stage of the active phase.

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“…Due to frequent adverse effects associated with pain therapy, the search for new and effective drugs with either no or least undesirable effects is necessary [7] Different chemical compounds such as flavonoids having potent analgesic effects have been obtained from natural sources, resulting in novel lead compound classes for designing of analgesic drugs [8]. Moreover, cinnamic acid, phenolic acids and caffeic acid, demonstrated to have anti-inflammatory and antinociceptive effects are considered promising phytochemicals that show distinct physiological and pharmacological properties [2,9].…”

Section: Introductionmentioning

confidence: 99%

Effects of Green Brazilian Propolis Alcohol Extract on Nociceptive Pain Models in Rats

Al-Hariri

Abualait

2020

Plants

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Pain is one of the most common symptoms encountered in the medical practice. None of the management procedures used currently offer a complete relief for patients suffering from nociceptive pain. New treatment strategies for pain management are needed. Propolis has been used in traditional medicine to relieve various types of pain. The aim of the current study was to investigate the potential effects of the green Brazilian propolis alcohol extract in vivo on the nociceptive and inflammatory pain models in rats. Rats were distributed into three random groups (n = 6); Group I: control group received normal saline intraperitoneally (i.p.); Group II: treated with green Brazilian propolis alcohol extract (P50 mg/kg i.p.); Group III: treated with P100 mg/kg i.p. After sixty minutes, 50 μL of 5% formalin was injected subcutaneously into the dorsal surface of the right hind paw. The nociceptive response was identified by counting the number of flinches of the injected paw. The number of flinches was counted for the period of 0–5 min (early phase; neurogenic) and 10–60 min (late phase; inflammatory). Thermal hyperalgesia was assessed using three-paw withdrawal latency measurement with ten minutes intervals using a planter analgesic meter. Abdominal writhe (contraction) was induced by i.p. injection of acetic acid (1 mL of 2%). The results showed that green Brazilian propolis alcohol extract caused a significant inhibition of acetic acid-induced pain and significantly increased the pain threshold against infrared and formalin tests. The promising antinociceptive and anti-inflammatory properties of propolis and/or its active constituents as natural compounds in the present study indicates that it merits further studies in pain.

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Natural Products as a Source for Novel Analgesic Compounds

Cited by 9 publications

References 73 publications

<p>Antinociceptive Effect of the Citrus Flavonoid Eriocitrinon Postoperative Pain Conditions</p>

<p>Antinociceptive Effect of the Citrus Flavonoid Eriocitrinon Postoperative Pain Conditions</p>

The Role of Red Ginger and Warm Water in Relieving Labor Pain

Effects of Green Brazilian Propolis Alcohol Extract on Nociceptive Pain Models in Rats

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