Natural Products as a Source of Potential Cancer Chemotherapeutic and Chemopreventive Agents

Cassady, John M.; Baird, William M.; Chang, Ching‐Jer

doi:10.1021/np50067a003

Cited by 199 publications

(119 citation statements)

References 78 publications

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“…Some sesquiterpenes and diterpenes are known to be cytotoxic and to inhibit tumors, with toxic sesquiterpenes generally containing one or more functional alkylating groups which suggests that they are possibly mutagenic and carcinogenic (Cassady and Baird, 1990;Wall et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

In vivo evaluation of the mutagenic potential and phytochemical characterization of oleoresin from Copaifera duckei Dwyer

et al. 2005

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We characterized the chemical constituents of Copaifera duckei oleoresin and used dermal application to Wistar rats to evaluated its possible mutagenic and cytotoxic activities on peripheral blood reticulocytes and bone marrow cells. Chemical characterization of the oleoresin revealed the presence of sesquiterpene hydrocarbons, an unidentified neutral diterpene and diterpene acids. To evaluate mutagenicity evaluation the rats were treated with 10, 25 and 50% of the LD 50 dose of the oleoresin for three consecutive days and peripheral blood collected after 0, 24, 48 and 72 h for micronucleus analysis. The rats were humanly sacrificed 24 hours after the last treatment and chromosome preparations made using standard techniques. At the three concentrations and the three time intervals tested we found that there were no statistically significant differences in either the mean number of micronucleated reticulocytes (MNRETs) or the number of chromosomal aberrations as to the negative control. However, at 25 and 50% of the LD 50 dose of the oleoresin there was a significant decrease in the mitotic index (MI) as compared to the negative control. Under our experimental conditions, C. duckei V11 oleoresin produced no mutagenic effects on bone marrow cells or in peripheral reticulocytes as assessed by chromosome aberrations and the micronucleus test respectively, but showed cytotoxic activity at high doses.

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Section: Discussionmentioning

confidence: 99%

In vivo evaluation of the mutagenic potential and phytochemical characterization of oleoresin from Copaifera duckei Dwyer

et al. 2005

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“…[2][3][4][5] Though no plant derived compound has been found to compete with clinically used antibiotics, to date, the great structural variety found in plants makes them attractive as a source of novel lead compounds. In fact, higher plants frequently exhibit significant potency against human bacterial and fungal pathogens.…”

Section: Introductionmentioning

confidence: 99%

Antistaphylococcal Activity of Xanthium cavanillesii Lactones

Olivaro¹,

Paris²,

Cerdeiras³

et al. 2014

phcog J

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Objective: the genus Xanthium l., of the Asteraceae Dum. family, (tribe Heliantheae) comprises 30 species of cosmopolitan distribution, many of which, as X. spinosum and X. strumarium are used as medicinal plants. this genus has been the object of numerous phytochemical investigations being sesquiterpene lactones with guaiane or secoguaiane frameworks the main secondary metabolites. Several sesquiterpene lactones have been demonstrated to have antimicrobial activity, in particular against Gram+ bacteria and in Uruguay the infusion of Xanthium cavanillesii Show (common name "abrojo" or "abrojo grande") which grows wild, is used as antiseptic in popular medicine. In this work we present the results of the antibacterial analysis of several extracts, fractions and pure compounds from X. cavanillesii against both sensitive and resistant strains of Staphylococcus aureus. Materials and Methods: Compounds were isolated from X. cavanillesii aerial parts by several chromatographic and spectroscopic methods antimicrobial analysis were performed according to Clinical and laboratory Standards Institute guidelines. Results: The minimum inhibitory concentration (MIC) found were high for the sensitive 6538p strain when compared with common antibiotics. For the resistant strains, the pure compounds activity clearly outperformed the antibiotics, especially in the case of the multiresistant 700,699 strain with MICs of 31, 236 and 356 µg/mL for the Xanthium compounds, gentamicin and oxacillin respectively.

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“…[1][2][3][4] Therefore, many efforts have been dedicated to search for reactions that can furnish homochiral α-tetralols. There are several reports dealing with the asymmetric hydrogenation of the α-tetralone itself, [5][6][7][8][9][10][11] as well as with its bioreduction, using either isolated enzymes or microorganisms.…”

Section: Introductionmentioning

confidence: 99%

Bioreduction of substituted a-tetralones promoted by Daucus carota root

Ferraz¹,

Bianco²,

Bombonato³

et al. 2008

Quím. Nova

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Recebido em 15/1/08; aceito em 27/2/08; publicado na web em 2/4/09The bioreduction of a series of substituted α-tetralones, carried out using Daucus carota root (carrot), afforded the corresponding homochiral α-tetralols in variable conversions (9 to 90%) and excellent enantiomeric excesses. Two of the assayed α-tetralones were resistant to the bioreduction conditions. The absolute configurations of four α-tetralols were assigned as being (S), by comparison to the (S)-enantiomers obtained by kinetic resolution promoted by CALB-catalysed acetylation. Additionally, the new 5-methoxy-6-methyl-1-tetralone was synthesized in seven steps from 3-methylsalicylic acid.

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Natural Products as a Source of Potential Cancer Chemotherapeutic and Chemopreventive Agents

Cited by 199 publications

References 78 publications

In vivo evaluation of the mutagenic potential and phytochemical characterization of oleoresin from Copaifera duckei Dwyer

In vivo evaluation of the mutagenic potential and phytochemical characterization of oleoresin from Copaifera duckei Dwyer

Antistaphylococcal Activity of Xanthium cavanillesii Lactones

Bioreduction of substituted a-tetralones promoted by Daucus carota root

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